Comparison of contrast-enhanced ultrasonography and magnetic resonance imaging in the evaluation of tumor size and local invasion of surgically treated cervical cancer

Wu, Manli; Wu, Jiawei; Huang, Linli; Chen, Ying; Qu, Enze; Xu, Jing; Kuang, Xiaohong; Zhang, Xinling

doi:10.1007/s00261-022-03558-6

Cited by 6 publications

(4 citation statements)

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“…CEUS quantitative analysis software draws TIC and extracts CEUS-related parameters to analyze CEUS parameters, providing key information for diagnostic staging and tumor response assessment ( 30 ). To date, there have been few studies on CEUS in cervical cancer ( 31 ), especially in evaluating the efficacy in cervical cancer. In this study, the combination of CEUS and USE technology was used to predict the efficacy of CCRT in patients with advanced cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound combined with elastic imaging for predicting the efficacy of concurrent chemoradiotherapy in cervical cancer: a feasibility study

Ma,

Zhao,

Chen

2024

Front. Oncol.

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ObjectiveContrast-enhanced ultrasound (CEUS) and elastography are of great value in the diagnosis of cervical cancer (CC). However, there is limited research on the role of contrast-enhanced ultrasound combined with elastography in predicting concurrent chemoradiotherapy and disease progression for cervical cancer. The purpose of this study was to evaluate the feasibility of contrast-enhanced ultrasound combined with elastography and tumor prognosis.MethodsMRI was performed on 98 patients with cervical cancer before and after treatment. Before, during, and 1 week after the treatment, contrast-enhanced ultrasound and elastography were conducted, and the alterations of ultrasound-related parameters at each time point of the treatment were compared. The correlation between contrast-enhanced ultrasound combined with elastic imaging and oncological outcome was assessed.ResultsThere was no notable difference in overall clinical data between the complete remission (CR) group and the partial remission (PR) group (P>0.05). Before treatment, there were no statistically significant differences in elasticity score, time to peak (TTP), and peak intensity (PI) between the CR group and the PR group. However, there were no statistical differences in elastic strain ratio (SR) and area under the curve (AUC) before and after treatment between the CR group and the PR group, and there were also no statistical differences in the elastic strain ratio (SR) and area under the curve (AUC) of contrast-enhanced ultrasound parameters between the CR group and the PR group before and during treatment. There was a statistically significant difference after treatment (P<0.05).At present, the follow-up of patients is about 1 year, 7 patients were excluded due to loss to follow-up, and 91 patients were included in the follow-up study. Through the review of the cases and combined with MRI (version RECIST1.1) and serology and other related examinations, if the patient has a new lesion or the lesion is larger than before, the tumor marker Squamous cell carcinoma antigen (SCC-Ag) is significantly increased twice in a row, and the patient is divided into progressive disease (PD). Those who did not see significant changes were divided into stable disease (SD) group. The relationship between clinical characteristics, ultrasound parameters and disease progression in 91 patients was compared. There was no significant difference in age and clinical stage between the two groups (P>0.05), but there was a significant difference in the elevation of tumor marker squamous cell carcinoma antigen (SCC-Ag) between the two groups (P<0.05).With the growth of tumors, TTP decreased, elasticity score and PI increased, and the difference was statistically significant (P<0.05). The AUC of SCC-Ag was 0.655, the sensitivity was 85.3%, and the specificity was 45.6%.The AUC, sensitivity and specificity of ultrasound parameters combined with SCC-Ag predicted disease progression was 0.959, 91.2% and 94.8%.ConclusionsUsing contrast-enhanced ultrasound and elastography to predict the efficacy and disease progression of concurrent chemoradiotherapy is feasible. In addition, the combination of SCC-Ag with contrast-enhanced ultrasound and elastography can further enhance the efficiency of predicting disease progression.

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Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound combined with elastic imaging for predicting the efficacy of concurrent chemoradiotherapy in cervical cancer: a feasibility study

Ma,

Zhao,

Chen

2024

Front. Oncol.

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“…), breast, ovarian, lung, renal, prostate, etc. Hepatocellular carcinoma, cholangiocarcinoma, mixed hepatocellular and cholangiocarcinoma, hepatoblastoma, bile duct cystadenocarcinoma, fibro lamellar carcinoma, and mesenchymal tissue tumors are the predominant types of malignant primary liver cancers [8][9][10] . Hepatoblastoma is the most prevalent malignant tumor found in children.…”

Section: Introductionmentioning

confidence: 99%

Assessment of focal liver lesions using magnetic resonance imaging, with a comparison to histopathological findings

Sireesha,

Nagaveni

2024

Int. J. Radiol. Diagn. Imaging

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There has been a rise in the incidence of accidentally discovered focal liver lesions (FLL) due to the widespread use of cross-sectional imaging. Having a reliable method for detecting and characterizing Focal Liver Lesions (FLL) is crucial for ensuring appropriate patient therapy. Within the realm of FLL, attaining the maximal level of imaging precision is crucial in order to avoid unnecessary biopsies, which may result in post-procedural complications. In recent years, there has been a substantial rise in the advancement of cutting-edge imaging techniques. Currently, magnetic resonance imaging (MRI) is essential in the treatment of liver abnormalities. This imaging method utilizes a radiation-free technique and has a safe contrast agent profile. MRI plays a crucial role in accurately characterizing FLL without the need for intrusive procedures. The magnetic resonance imaging (MRI) approach has the capacity to provide comprehensive and highly precise diagnostic information, while also avoiding the use of any potentially hazardous ionizing radiation. Because of these specific attributes, magnetic resonance imaging has emerged as the preferred technique for the non-invasive assessment of localized liver lesions. This study focuses on the role of contrast agents that specifically target hepatocytes and provides a comprehensive overview of the most advanced magnetic resonance imaging (MRI) liver procedure. In addition, we provide a concise overview of the many types of sequences, as well as the unique attributes of imaging patients that exhibit non-cooperative behavior. This page provides a comprehensive analysis of the imaging features of both benign and malignant FLLs. Addit ionally, it includes a diagrammatic representation of a practical MRI technique.

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“…Magnetic resonance imaging (MRI) is currently the standard technique for local staging and prognostic evaluation of cervical cancer before treatment [10][11][12][13]. MRI is effective in determining the cancer stage for treatment optimization by evaluating parauterine invasion, tumor subtype and grade, and lymph node metastasis (LNM).…”

Section: Introductionmentioning

confidence: 99%

Preoperative prediction of cervical cancer survival using a high-resolution MRI-based radiomics nomogram

Zhou

Lü

et al. 2023

Preprint

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Background Cervical cancer patients receiving radiotherapy and chemotherapy require accurate survival prediction methods. The objective of this study was to develop a prognostic analysis model based on a radiomics score to predict overall survival (OS) in cervical cancer patients. Methods Predictive models were developed using data from 62 cervical cancer patients who underwent radical hysterectomy between June 2020 and June 2021. Radiological features were extracted from T2-weighted (T2W), T1-weighted (T1W), and diffusion-weighted (DW) magnetic resonance images prior to treatment. We obtained the radiomics score (rad-score) using least absolute shrinkage and selection operator (LASSO) regression and Cox’s proportional hazard model. We divided the patients into low- and high-risk groups according to the critical rad-score value, and generated a nomogram incorporating radiological features. We evaluated the model’s prediction performance using area under the receiver operating characteristic (ROC) curve (AUC) and classified the participants into high- and low-risk groups based on radiological characteristics. Results The 62 patients were divided into high-risk (n = 43) and low-risk (n = 19) groups based on the rad-score. Four feature parameters were selected via dimensionality reduction, and the scores were calculated after modeling. The AUC values of ROC curves for prediction of 3- and 5-year OS using the model were 0.84 and 0.93, respectively. Conclusion Our nomogram incorporating a combination of radiological features demonstrated good performance in predicting cervical cancer OS. This study highlights the potential of radiomics analysis in improving survival prediction for cervical cancer patients. However, further studies on a larger scale and external validation cohorts are necessary to validate its potential clinical utility.

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Comparison of contrast-enhanced ultrasonography and magnetic resonance imaging in the evaluation of tumor size and local invasion of surgically treated cervical cancer

Cited by 6 publications

References 19 publications

Contrast-enhanced ultrasound combined with elastic imaging for predicting the efficacy of concurrent chemoradiotherapy in cervical cancer: a feasibility study

Contrast-enhanced ultrasound combined with elastic imaging for predicting the efficacy of concurrent chemoradiotherapy in cervical cancer: a feasibility study

Assessment of focal liver lesions using magnetic resonance imaging, with a comparison to histopathological findings

Preoperative prediction of cervical cancer survival using a high-resolution MRI-based radiomics nomogram

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