Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy

Esquenazi, Salomon; He, Jiucheng; Bazán, Nicolás G.; Bazán, Haydee E. P.

doi:10.1016/j.jcrs.2005.01.011

Cited by 47 publications

(32 citation statements)

References 25 publications

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“…This evidence was further complemented by recent laboratory experiments using human and rabbit corneas, which showed a mitigated keratocyte response to LASEK compared with PRK. 37,38 These reasons constituted to the choice of LASEK procedure in our patients.…”

Section: Perioperative Data and Early Postoperative Recoverymentioning

confidence: 95%

Topography-guided customized laser-assisted subepithelial keratectomy for the treatment of postkeratoplasty astigmatism

Rajan

O’Brart²,

Patel³

et al. 2006

Journal of Cataract and Refractive Surgery

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Section: Perioperative Data and Early Postoperative Recoverymentioning

confidence: 95%

Topography-guided customized laser-assisted subepithelial keratectomy for the treatment of postkeratoplasty astigmatism

Rajan

O’Brart²,

Patel³

et al. 2006

Journal of Cataract and Refractive Surgery

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“…According to recent findings reported by Esquenazi et al [8] , eyes treated with laser-assisted subepithelial keratectomy showed less keratocyte apoptosis, myofibroblast transformation, and upregulation in the synthesis of chondroitin sulphate than PRK-treated eyes. These differences may account for better visual acuities and less stromal haze after laser-assisted subepithelial keratectomy [8] .…”

Section: Introductionmentioning

confidence: 80%

“…These differences may account for better visual acuities and less stromal haze after laser-assisted subepithelial keratectomy [8] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Cytochrome <i>c</i> Peroxidase on the Corneal Epithelial Healing Process after Excimer Laser Photo-Ablation in Transgenic Mice

Scorolli

Meduri²,

Morara³

et al. 2007

Eur Surg Res

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Aim: To evaluate the role of commercially prepared cytochrome c peroxidase eye drops in corneal epithelial healing of transgenic B6(A)-Rpe65rd12/J mice after excimer laser photo-ablation. Materials and Methods: In our prospective animal series, 72 eyes of 36 mice had uneventful bilateral excimer laser photo-ablation. In each mouse, one eye received standard topical postoperative therapy with tobramycin, diclofenac, and dexamethasone eye drops plus cytochrome c peroxidase eye drops (two drops three times a day for 1 week or until corneal re-epithelialization was complete, corresponding to 15,000 IU/day). The fellow eye served as the control and received standard postoperative therapy plus placebo. The mice were monitored daily, commencing on the day after surgery, for 7 days to evaluate the corneal re-epithelialization rate using a video slit lamp camera with cobalt blue light. The mean diameter of the corneal wounds was measured. Videotaped images were recorded and analyzed by computer planimetry. Results: All eyes treated with cytochrome c peroxidase eye drops healed completely before day 5 after surgery, with a mean re-epithelialization time of 92 ± (SD) 10 h; the mean re-epithelialization time was 121 ± 8 h in the eyes receiving placebo (p < 0.05). There were no statistically significant differences between the two groups in corneal haze presentation during the follow-up period (p = 0.70), perhaps because the observation period was too short (7 days). However, the corneal clarity, on slit lamp biomicroscopy, in the study group was higher than that in the control group. No side effects or toxic effects were observed. Conclusions: These data suggest that cytochrome c peroxidase significantly accelerates epithelial healing after phototherapeutic keratectomy. Further clinical studies should be performed to prove the results obtained in this study and the long-term efficacy of cytochrome c peroxidase to prevent corneal haze.

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“…According to a previous study done by Esquenazi et al [8], after excimer photoablation, the eyes treated with laser-assisted epithelial keratomileusis showed less keratocyte apoptosis, myofibroblast transformation and upregulation in the synthesis of chondroitin sulfate than those treated with PRK. These differences may account for better visual acuities and less stromal haze in higher attempted corrections in the eyes treated with laser-assisted epithelial keratomileusis.…”

Section: Introductionmentioning

confidence: 96%

Effect of Basic Fibroblast Growth Factor in Transgenic Mice: Corneal Epithelial Healing Process after Excimer Laser Photoablation

Meduri

Scalinci²,

Morara³

et al. 2008

Ophthalmologica

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Purpose: To evaluate the role of preparedbasic fibroblast growth factor (bFGF) eyedrops in corneal epithelial healing of transgenic mice after excimer laser photoablation. Materials and Methods: In our prospective case series, 60 eyes of 30 mice had uneventful bilateral excimer laser photoablation. In each mouse, 1 eye received the standard topical postoperative therapy with tobramicin, diclofenac and dexamethasone eyedrops, plusbFGF eyedrops 5 μg/10 μl PBS 3 times a day for 1 week, or until corneal reepithelialization was complete. The fellow eye served as the control and received the standard postoperative therapy plus placebo. The mice were monitored daily, commencing the day after surgery and for 7 days, in order to evaluate the corneal reepithelialization rate by using a video slitlamp camera with a cobalt blue light. The mean diameter of the corneal wounds was measured. Videotaped images were recorded and analyzed by computer planimetry. Results: All the eyes treated withbFGF eyedrops healed completely before day 5 after surgery, with a mean reepithelialization time of 90 ± 12 h (standard deviation); the mean reepithelialization time was 124 ± 10 h in those eyes receiving placebo. There were no statistically significant differences between the 2 groups in corneal haze presentation during the follow-up, perhaps because the time period was too brief (7 days). However, corneal clarity on slitlamp biomicroscopy was greater in the study group than in the control group. No side effects or toxic effects were documented. Conclusions: These data suggest that the bFGF significantly accelerates epithelial healing after excimer photoablation. A further clinical study should be performed to prove the results obtained in this study as well as the long-term efficacy of bFGF to prevent corneal haze.

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Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy

Cited by 47 publications

References 25 publications

Topography-guided customized laser-assisted subepithelial keratectomy for the treatment of postkeratoplasty astigmatism

Topography-guided customized laser-assisted subepithelial keratectomy for the treatment of postkeratoplasty astigmatism

Effect of Cytochrome <i>c</i> Peroxidase on the Corneal Epithelial Healing Process after Excimer Laser Photo-Ablation in Transgenic Mice

Effect of Basic Fibroblast Growth Factor in Transgenic Mice: Corneal Epithelial Healing Process after Excimer Laser Photoablation

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