Comparison of cryopreserved and air-dried human amniotic membrane for ophthalmologic applications

Thomasen, Henning; Pauklin, Mikk; Steuhl, Klaus‐Peter; Meller, Daniel

doi:10.1007/s00417-009-1162-y

Cited by 74 publications

(55 citation statements)

References 61 publications

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“…However, different processing methods may impact the composition and functionality of placental membranes to varying degrees. 41,61 Most placental membrane products contain no viable cells. They are either dehydrated or cryopreserved with devitalized or decellularized tissue.…”

Section: Commercial Placental Membrane Productsmentioning

confidence: 99%

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Use of Placental Membranes for the Treatment of Chronic Diabetic Foot Ulcers

Brantley

Verla

2015

Advances in Wound Care

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Significance: Chronic diabetic foot ulcers (DFUs) remain a challenge for physicians to treat. High mortality rates for DFU patients have pointed to the low effectiveness of standard care and lack of quality wound care products. The composition (collagen-rich tissue matrix and endogenous growth factors and cells) and functional properties (anti-inflammatory, anti-bacterial, and angiogenic) of placental membranes are uniquely suited to address the needs of chronic wounds. This led to the commercialization of placental membranes, which are now widely available to physicians as a new advanced wound treatment option.Recent Advances: Progress in tissue processing and preservation methods has facilitated the development of placental products for wounds. Currently, a variety of commercial placental products are available to physicians for the treatment of chronic DFUs and other wounds. This review summarizes the key factors that negatively impact DFU healing (including social factors, such as smoking, vascular deficiencies, hyperglycemia, and other metabolic abnormalities), describes the structure and biology of placental membranes, and overviews commercially available placental products for wounds and data from the most recent DFU clinical trials utilizing commercial placental membranes.Critical Issues: Although the effects of diabetes on wound healing are complex and not fully understood, some of the key factors and pathways that interfere with healing have been identified. However, a multidisciplinary approach for the assessment of patients with chronic DFUs and guidelines for selection of appropriate treatment modalities remain to be implemented.Future Directions: The biological properties of placental membranes show benefits for the treatment of chronic DFUs, but scientific and clinical data for commercially available placental products are limited. Therefore, we need (1) more randomized, controlled clinical trials for commercial placental products; (2) studies that help to understand the timing of placental products' application and criteria for patient selection; and (3) studies comparing the functional properties of different commercially available placental products.

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Section: Commercial Placental Membrane Productsmentioning

confidence: 99%

“…A comparison of amniotic and chorionic membranes composition and properties is summarized in Table 1. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] …”

Section: Amnion and Chorion Structurementioning

confidence: 99%

Use of Placental Membranes for the Treatment of Chronic Diabetic Foot Ulcers

Brantley

Verla

2015

Advances in Wound Care

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“…As the temperature inside the hyperdrying device does not exceed 35 • C during drying, it is thought that the beneficial characteristics of fresh amniotic membrane are retained in the dried ␥-irradiated amniotic membrane. 17,[23][24][25] We used xenogenous grafts in this study. We need to repeat experiments with allogeneic grafts, possibly in pigs, and ultimately in carefully-selected patients as previously reported with cryopreserved amniotic membrane.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25] Hyperdry membrane is produced using far infrared and microwave irradiation, and is then sterilised by ␥-irradiation. It can be preserved dry at room temperature, and can be cut easily into the desired size and shape with scissors just before use.…”

Section: Discussionmentioning

confidence: 99%

Use of hyperdry amniotic membrane in operations for cleft palate: a study in rats

Tsuno

Noguchi

Okabe

et al. 2015

British Journal of Oral and Maxillofacial Surgery

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“…Preserved amnions have been used for decades in various clinical fields, including ophthalmology and wound care. [14][15][16][17][18][19] For preservable amnions, cryopreservation of amniotic membranes is the most common preservation method and it is used widely to treat various wounds. However, there have been some problems in the storage and sterilization of the material in this method.…”

mentioning

confidence: 99%