Comparison of Diagnostic Values of Maternal Arginine Concentration for Different Pregnancy Complications: A Systematic Review and Meta-Analysis

Xu, Lianbin; Zeng, Jia; Wang, Huanan; Liu, H.Y.

doi:10.3390/biomedicines10010166

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…Xu L. и соавт. в своей работе выделили аргинин как важный маркер осложнений беременности, ученые доказали повышенные концентрации материнского аргинина при ЗРП, гестационном сахарном диабете, преэклампсии [17].…”

Section:  результаты и обсуждениеunclassified

Features of the Maternal Metabolom in Fetal Growth Delay

Ганчар¹,

Гутикова²,

Наумов³

2022

Репродуктивное Здоровье. Восточная Европа

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Цель. Изучить особенности метаболома у беременных с задержкой роста плода.Материалы и методы. В ходе исследования изучены образцы плазмы крови 41 женщины. Беременные были разделены на группы: 1-ю группу составила 21 беременная с задержкой роста плода, 2-ю группу – 20 женщин с физиологическим течением беременности. Анализ образцов был осуществлен с помощью высокоэффективной жидкостной хроматографии. Статистическая обработка полученных данных осуществлялась с использованием пакета программ Statistica 10.0 (SN – AXAR207F394425FA-Q).Результаты. У пациенток с задержкой роста плода в плазме крови выявлено статистически значимое повышение 14 аминокислот и их производных по сравнению с контрольной группой: цистеиновой кислоты (СА), фосфосерина (PSer), аспарагина (Asn), серина (Ser), треонина (Thr), 1-метилгистидина (1MHis), 3-метилгистидина (1MHis), аргинина (Arg), симметричного диметиларгинина (SDMA), α-аминомасляной кислоты (αАВА), β-аминомасляной кислоты (βАВА), метионина (Met), триптофана (Trp), лейцина (Leu). Выявлена умеренная корреляционная связь массы плода с уровнем цистеиновой кислоты (СА), фосфосерина (PSer), серина (Ser), 3-метилгистидина (3MHis), треонина (Thr), аланина (Ala), таурина (Tau), симметричного диметиларгинина (SDMA), α-аминомасляной кислоты (aABA), β-аминомасляной кислоты (βАВА), триптофана (Trp); сильная корреляционная связь определена с аспарагином (Asn).Заключение. Полученные результаты обосновывают перспективность изучения метаболомики в качестве диагностических маркеров задержки роста плода. Purpose. To study the features of the metabolome in pregnant women with fetal growth retardation.Materials and methods. During the study, blood plasma samples from 41 women were studied. The pregnant women were divided into groups: the 1st group consisted of 21 pregnant women with fetal growth retardation, the 2nd group – 20 women with a physiological course of pregnancy. Samples were analyzed by high performance liquid chromatography. Statistical processing of the obtained data was carried out using the Statistica 10.0 software package (SN – AXAR207F394425FA-Q).Results. In patients with fetal growth retardation in blood plasma, a statistically significant increase in 14 amino acids and their derivatives was revealed compared to the control group: cysteic acid (CA), phosphoserine (PSer), asparagine (Asn), serine (Ser), threonine (Thr), 1-methylhistidine (1MHis), 3-methylhistidine (1MHis), arginine (Arg), symmetrical dimethylarginine (SDMA), α-aminobutyric acid (αABA), β-aminobutyric acid (βABA), methionine (Met), tryptophan (Trp), leucine (Leu). A moderate correlation was found between fetal weight and the level of cysteic acid (CA), phosphoserine (PSer), serine (Ser), 3-methylhistidine (3MHis), threonine (Thr), alanine (Ala), taurine (Tau), symmetrical dimethylarginine (SDMA), α-aminobutyric acid (aABA), β-aminobutyric acid (βABA), tryptophan (Trp); a strong correlation was determined with asparagine (Asn).Conclusion. The results obtained substantiate the prospects of studying metabolomics as diagnostic markers of fetal growth retardation.

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Section:  результаты и обсуждениеunclassified

Features of the Maternal Metabolom in Fetal Growth Delay

Ганчар¹,

Гутикова²,

Наумов³

2022

Репродуктивное Здоровье. Восточная Европа

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Ammonium nanochelators in conjunction with arginine-specific enzymes in amperometric biosensors for arginine assay

Stasyuk,

Gayda,

Nogala

et al. 2023

Microchim Acta

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Amino acid L-arginine (Arg), usually presented in food products and biological liquids, can serve both as a useful indicator of food quality and an important biomarker in medicine. The biosensors based on Arg-selective enzymes are the most promising devices for Arg assay. In this research, three types of amperometric biosensors have been fabricated. They exploit arginine oxidase (ArgO), recombinant arginase I (ARG)/urease, and arginine deiminase (ADI) coupled with the ammonium-chelating redox-active nanoparticles. Cadmium-copper nanoparticles (nCdCu) as the most effective nanochelators were used for the development of ammonium chemosensors and enzyme-coupled Arg biosensors. The fabricated enzyme/nCdCu-containing bioelectrodes show wide linear ranges (up to 200 µM), satisfactory storage stabilities (14 days), and high sensitivities (A⋅M−1⋅m−2) to Arg: 1650, 1700, and 4500 for ADI-, ArgO- and ARG/urease-based sensors, respectively. All biosensors have been exploited to estimate Arg content in commercial juices. The obtained data correlate well with the values obtained by the reference method. A hypothetic scheme for mechanism of action of ammonium nanochelators in electron transfer reaction on the arginine-sensing electrodes has been proposed. Graphical abstract

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