Comparison of dialdehyde polysaccharides as crosslinkers for hydrogels: The case of poly(vinyl alcohol)

Nanocellulose-based hydrogels for drug delivery

“…100 It is believed that simple and non-toxic reaction is extremely important in DDSs and has the value of further development and research. 99…”

“…It was found that, with the increase of the chitosan content, the swelling volume of the hydrogel increased, and the isoelectric point moved to alkaline. Besides, Muchova et al 98,99 designed a hydrogel film made by DAC crosslinked with PVA for DDSs and wound dressings. Compared with the uniformly GA crosslinked hydrogel, much larger molecules like DAC could crosslink numerous PVA simultaneously, offering higher crosslink density and resulting in better mechanical properties of hydrogels.…”

Recent Progress in Metal‐Catalyzed Selective Oxidation of 5‐Hydroxymethylfurfural into Furan‐Based Value‐Added Chemicals

“…Among these furan-based chemicals, DFF is a useful precursor that can be used to make a variety of significant chemicals or materials, including furan-based biopolymers, [7] pharmaceutical intermediates, [8] antimicrobials, [8] surfactants, [9] poly Schiff bases, [10] and polyvinyl alcohol crosslinkers. [11] HMFCA is an attractive monomer for the production of a furan-based polyester, [12] which shows anti-tumor activity [13] in the pharmaceutical field and good neuroprotective, [14] antiinflammatory [15] and interleukin inhibitory effects. [16] In terms of FFCA, it has broad application prospects in chemical and biological materials.…”

“…In practice, HMF can be selectively oxidized into diverse value‐added chemicals, including 2,5‐diformylfuran (DFF), 5‐hydroxymethyl‐2‐furancarboxylic acid (HMFCA), 5‐formyl‐2‐furancarboxylic acid (FFCA), and 2,5‐furandicarboxylic acid (FDCA). Among these furan‐based chemicals, DFF is a useful precursor that can be used to make a variety of significant chemicals or materials, including furan‐based biopolymers, [7] pharmaceutical intermediates, [8] antimicrobials, [8] surfactants, [9] poly Schiff bases, [10] and polyvinyl alcohol crosslinkers [11] . HMFCA is an attractive monomer for the production of a furan‐based polyester, [12] which shows anti‐tumor activity [13] in the pharmaceutical field and good neuroprotective, [14] anti‐inflammatory [15] and interleukin inhibitory effects [16] .…”

Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative

“…(Kristiansen et al, 2013) DAH is often utilized in biomedical sciences for hydrogel preparation, in which the highly reactive -CHO groups react with -OH groups (hemiacetalization) or -NH2 groups (Schiff base formation) of the substrate. For example, DAH was used as a crosslinking agent in our recent comparative crosslinking study focused on the evaluation of the influence of various dialdehyde polysaccharides on poly(vinyl) alcohol-based hydrogel properties, (Muchová et al, 2022) for the preparation of hybrid chitosan hydrogels and their application in abdominal tissue regeneration, or as a partially oxidized matrix crosslinked by adipic acid anhydride to form bio-printable hydrogel materials. (Weis et al, 2018) The recent renaissance of periodate oxidation, historically used mainly in polysaccharide characterization, thus opens new synthetic routes for the preparation of many functional (bio)materials.…”