Comparison of Disease Characteristics, Organ Damage, and Survival in Patients with Juvenile-onset and Adult-onset Systemic Lupus Erythematosus in a Combined Cohort from 2 Tertiary Centers in Turkey

Artim‐Esen, Bahar; Şahin, Sezgin; Çene, Erhan; Şahinkaya, Yasemin; Barut, Kenan; Adroviç, Amra; Özlük, Yasemin; Kiliçaslan, İşın; Omma, Ahmet; Gül, Ahmet; Öçal, Lale; Kasapçopur, Özgür; İnanç, Murat

doi:10.3899/jrheum.160340

Cited by 47 publications

(53 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, 17% of the patients were grouped into a cluster with prevalent renal (55.4%) and ocular damage (58.0%), which resembled cluster 2 of the juvenile SLE study (14.5% of total patients, 60% with renal damage, 54.0% with ocular damage), while Pego‐Reigosa et al identified no damage cluster with frequent renal damage among the adult patients with SLE. The presence of a renal damage cluster may be associated with the age or ethnic background of the included patients, as renal damage is significantly more frequent in Asian patients than Western patients and in juvenile‐onset SLE than in adult‐onset SLE …”

Section: Discussionmentioning

confidence: 99%

Identifying damage clusters in patients with systemic lupus erythematosus

Ahn

Lee²,

Won³

et al. 2019

Int J of Rheum Dis

View full text Add to dashboard Cite

Aim Systemic lupus erythematosus (SLE) causes irreversible damage to organ systems. Recently, evidence has been obtained for subphenotypes of SLE. This study aimed to identify damage clusters and compare the associated clinical manifestations, SLE disease activity, mortality, and genetic risk scores (GRS). Methods The study was conducted on the Hanyang BAE lupus cohort. Patients with disease duration <5 years were excluded to minimize confounding effects of disease duration. They were grouped into 3 clusters based on the Systemic Lupus International Collaborating Clinics Damage Index using k‐means cluster analysis. Results Among the 1130 analyzed patients, musculoskeletal damage was most prevalent (20.2%), followed by ocular (11.4%), renal (10.5%), and neuropsychiatric damage (10.2%). Three significantly different damage clusters were identified. Patients in cluster 1 (n = 824) showed the least damage. Cluster 2 (n = 195) was characterized by frequent renal (55.4%) and ocular (58.0%) damage, and cluster 3 (n = 111) was dominated by neuropsychiatric (100%) and musculoskeletal damage (35.1%). Cluster 2 had the highest adjusted mean AMS (adjusted mean SLE Disease Activity Index score; mean ± SD: 5.4 ± 2.9), while cluster 3 had the highest mortality (14.4%). Weighted GRS did not differ significantly between the clusters. Conclusion Patients in prevalent renal and ocular damage cluster had the highest AMS scores, while the cluster with frequent neuropsychiatric damage had the highest mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Identifying damage clusters in patients with systemic lupus erythematosus

Ahn

Lee²,

Won³

et al. 2019

Int J of Rheum Dis

View full text Add to dashboard Cite

show abstract

“…Accumulating disease damage from CLE correlates inversely with age of disease onset, producing physical and psychological implications during a formative time in development. In addition, paediatric‐onset SLE differs significantly from adult‐onset SLE, with a greater frequency of end‐organ damage including renal involvement at presentation, a requirement for sustained immunosuppression, and higher overall mortality . The validation of this tool in paediatric CLE will facilitate approval of much‐needed paediatric lupus treatments and help to standardize patient care …”

Section: Discussionmentioning

confidence: 99%

Evaluation of the reliability and validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) in paediatric cutaneous lupus among paediatric dermatologists and rheumatologists

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Among all SLE patients, 15-20% have a disease onset in childhood namely juvenile SLE (jSLE) 3 . Disease severity and outcome of jSLE patients are more severe than adult onset SLE due to the higher frequency of central nervous system and renal involvement; requiring more intense immunosuppressive treatments 4 . In the past two decades, with achieving early diagnosis and improved treatment modalities, jSLE patients might live longer with a chronic disease.…”

Section: Introductionmentioning

confidence: 99%

Çocukluk çağı başlangıçlı sistemik lupus eritematozus hastalarında avasküler nekrozis sıklığı

Balcı

Ekinci

Pişkin

et al. 2020

Cukurova Medical Journal

View full text Add to dashboard Cite

Öz Purpose: Avascular necrosis (AVN) is a debilitating complication of juvenile systemic lupus erythematosus (jSLE). The aim of this study was to evaluate the frequency and clinical characteristics of patients with AVN in jSLE from a single center. Material and Methods: Fifty-eight jSLE patients diagnosed according to the American College of Rheumatology classification criteria were included in this retrospective study. Disease activity of jSLE patients was measured by SLE Disease Activity Index-2K (SLEDAI-2K), organ damage was determined by the pediatric version of the systemic lupus international collaborating clinics/American College of Rheumatology damage index (pedSDI) at last visit. Results: Among 58 jSLE patients, the female patients accounted for 86.2% (n=50). Mean baseline SLEDAI-2K score was 21.47±8.96. The number of patients with at least one damage item of pedSDI was 24 (41.4%), in which 5 patients (8.6%) had AVN. There were no statistical differences between the groups except baseline complement 3 (C3) level was significantly lower in patients with AVN. Conclusion: Baseline low C3 level might be a predictor for AVN development in jSLE patients.There is unmet need for multicenter studies investigating possible risk factors of AVN in jSLE patients. Amaç: Avasküler nekrozis (AVN), çocukluk çağı başlangıçlı sistemik lupus eritematozusun (jSLE) yıkıcı bir komplikasyonudur. Tek merkezden yapılan bu çalışmanın amacı jSLE hastalarında AVN sıklığını ve bu hastaların klinik özelliklerini belirlemektir. Gereç ve Yöntem: Amerikan Romatoloji Koleji'nin sınıflama kriterlerine göre tanı almış 58 jSLE hastası bu geriye dönük çalışmaya dahil edildi. jSLE hastalarının hastalık aktiviteleri SLE hastalık aktivite indeksi baz alınarak (SLEDAI-2K) ölçüldü. Organ hasarı Amerikan Romatoloji Koleji'nin SLE hastalarında uyguladığı hasar indeksinin çocukluklardaki versiyonu kullanılarak son muayenede belirlendi. Bulgular: Elli sekiz jSLE hastasının %86,2 (50)'si kız hastaydı. Ortalama bazal SLEDAI-2K skoru 21,47±8,96 idi. En az bir organda hasarı olan hasta sayısı 24 (%41,4) idi, bunlardan 5 tanesinde (%8,6) AVN vardı. AVN olan ve olmayan hastalar arasında çeşitli değikenlere göre istatistiksel anlamlı bir farklılık saptanmadı. Sadece bazal kompleman 3 (C3) düzeyi AVN hastalarında, AVN olmayan hastalara göre anlamlı olarak düşüktü. Sonuç: Bazal düşük C3 düzeyi jSLE hastalarında AVN gelişimini tahmin etmede ön görücü olabilir. jSLE hastalarında AVN gelişimi için muhtemel risk faktörlerini inceleyen çok merkezli çalışmalara ihtiyaç vardır.

show abstract

Comparison of Disease Characteristics, Organ Damage, and Survival in Patients with Juvenile-onset and Adult-onset Systemic Lupus Erythematosus in a Combined Cohort from 2 Tertiary Centers in Turkey

Cited by 47 publications

References 44 publications

Identifying damage clusters in patients with systemic lupus erythematosus

Identifying damage clusters in patients with systemic lupus erythematosus

Evaluation of the reliability and validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) in paediatric cutaneous lupus among paediatric dermatologists and rheumatologists

Çocukluk çağı başlangıçlı sistemik lupus eritematozus hastalarında avasküler nekrozis sıklığı

Contact Info

Product

Resources

About