Comparison of Dissolution Profiles for Sustained Release Resinates of BCS Class I Drugs Using USP Apparatus 2 and 4: A Technical Note

Prabhu, Namita B; Marathe, Ajit S.; Jain, Sanmati K.; Singh, Pirthi Pal; Sawant, Kiran P; Rao, Leena; Amin, Purnima D.

doi:10.1208/s12249-008-9110-4

Cited by 11 publications

(10 citation statements)

References 15 publications

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“…The drug-loaded hydrogels showed a peak at 246°C. The ciprofloxacin hydrochloride showed a peak at 160°C for the presence of the water molecule and also a peak observed at it melting point of 323°C (Prabhu et al, 2008). The peak at 323°C shifted to 246°C in drug-loaded hydrogels, which is at the melting point of ciprofloxacin base (Francis et al, 1991).…”

Section: Resultsmentioning

confidence: 93%

Radiation Cross-Linked Carboxymethyl Sago Pulp Discs for Sustained Drug Delivery: Ciprofloxacin Uptake and Physicochemical Characterization

Pushpamalar¹,

Zakiah

Sathasivam³

et al. 2018

J App Pharm Sci

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Radiation cross-linked carboxymethyl sago pulp (CMSP) hydrogel discs with a gel fraction of 9.21% w/w were prepared at the radiation doses of 25 kGy. CMSP disc was loaded with ciprofloxacin hydrochloride by immersing in drug solution and evaluated for loading efficiency. The drug was loaded into the pre-cross-linked hydrogel to avoid radiation-induced degradation of the loaded drug. Drug loading of each disc (2 ± 0.2 mm thickness and of 4 ± 0.4 mm diameter) was found to be 2.96 ± 0.36 mg. Infrared and thermal analysis revealed no polymer-drug interaction and transformation of ciprofloxacin hydrochloride into ciprofloxacin base during the loading process. Thermal analysis and scanning electron microscopy revealed the crystalline nature of the loaded drug. The hydrogels sustained the drug release over 24 h and could be developed as sterile inserts for ophthalmic application to treat eye infections. The drug release from the hydrogel found to follow the first order and anomalous transport mechanism.

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Section: Resultsmentioning

confidence: 93%

Radiation Cross-Linked Carboxymethyl Sago Pulp Discs for Sustained Drug Delivery: Ciprofloxacin Uptake and Physicochemical Characterization

Pushpamalar¹,

Zakiah

Sathasivam³

et al. 2018

J App Pharm Sci

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“…Similarly, the release extent could also become higher as the solution volume increases. Prabhu et al28 reported that the release of diltiazem hydrochloride from resinates is about 40% in pH 1.2 solution in the same apparatus. In comparison, in our work, the release of the drugs from the complexes was more than 80%.…”

Section: Resultsmentioning

confidence: 97%

The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences

Yuan

Gao

Wang

et al. 2014

DDDT

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Ion-exchange fibers were different from conventional ion-exchange resins in their non-cross-linked structure. The exchange was located on the surface of the framework, and the transport resistance reduced significantly, which might mean that the exchange is controlled by an ionic reaction instead of diffusion. Therefore, this work aimed to investigate the load and release characteristics of five model drugs with the strong cationic ion-exchange fiber ZB-1. Drugs were loaded using a batch process and released in United States Pharmacopoeia (USP) dissolution apparatus 2. Opposing exchange kinetics, suitable for the special structure of the fiber, were developed for describing the exchange process with the help of thermodynamics, which illustrated that the load was controlled by an ionic reaction. The molecular weight was the most important factor to influence the drug load and release rate. Strong alkalinity and rings in the molecular structures made the affinity between the drug and fiber strong, while logP did not cause any profound differences. The drug–fiber complexes exhibited sustained release. Different kinds and concentrations of counter ions or different amounts of drug–fiber complexes in the release medium affected the release behavior, while the pH value was independent of it. The groundwork for in-depth exploration and further application of ion-exchange fibers has been laid.

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“…The FTC was developed to address some deficiencies perceived in other compendial techniques and offers a viable option for carrying out dissolution of various dosage forms such as tablets, powders, suppositories, hard gelatin capsules, implants, semisolids, and drug-eluting stents (34)(35)(36). This method has distinct advantages over the USP paddle and basket methods, especially for drugs with poor solubility and wettability (37,38).…”

Section: Pharmacokinetic Rationalementioning

confidence: 99%

“…Moreover, FTC is helpful in testing robustness of the formulation with respect to the variations in the intralumenal environment, maintaining sink conditions for the poorly solu-ble drugs (31,34,40), and non-tedious method to change pH of the dissolution medium (34,41). In addition, FTC systems offer other distinct advantages including (1) a built-in filtration system, (2) use as either an open or closed system, (3) a high degree of automation, (4) ideal hydrodynamic conditions for mild agitation, homogeneity, and definable flow (37,38), and (5) release from dosage forms over extended periods can be studied, as FTC eliminates the evaporation issue that can be observed with other apparatus (42).…”

Section: Pharmacokinetic Rationalementioning

confidence: 99%

In Vitro Release Evaluation of Gastroretentive Amoxicillin Floating Tablets Employing a Specific Design of the Flow-Through Cell

Emara¹,

Abdou²,

El-Ashmawy³

et al. 2013

Dissolution Technol.

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Floating amoxicillin trihydrate (AmoxT) tablets, used for eradication of Helicobacter pylori (H. pylori), were prepared according to a gas-generating technique to extend the drug residence time in the stomach. The drug release rate from the floating tablets in acidic dissolution medium, in which AmoxT is known to be unstable, was studied using two dissolution techniques: openloop system of the flow-through cell (FTC) and the beaker method. Analysis of AmoxT in the dissolution medium was carried out by UV spectrophotometric and HPLC methods. The comparison indicates that the open-loop system of the FTC, which is based on non-cumulative (fresh) dissolution samples, is the preferred dissolution technique, and in this case, the drug could be analyzed by UV spectrophotometric and HPLC methods. However, in the case of a large number of QC samples, UV spectrophotometry is preferred to the HPLC method, which requires relatively longer time for analysis thereby increasing drug degradation. On the other hand, in the case of the beaker method, which is based on cumulative dissolution samples, the drug must be analyzed by HPLC. Generally, the beaker method is not recommended due to the problems associated with the accumulation of AmoxT degradation product in the dissolution medium. This study describes a simple dissolution method capable of discriminating between different AmoxT gastroretentive formulations without any additional experimental or calculational steps.

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Comparison of Dissolution Profiles for Sustained Release Resinates of BCS Class I Drugs Using USP Apparatus 2 and 4: A Technical Note

Cited by 11 publications

References 15 publications

Radiation Cross-Linked Carboxymethyl Sago Pulp Discs for Sustained Drug Delivery: Ciprofloxacin Uptake and Physicochemical Characterization

Radiation Cross-Linked Carboxymethyl Sago Pulp Discs for Sustained Drug Delivery: Ciprofloxacin Uptake and Physicochemical Characterization

The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences

In Vitro Release Evaluation of Gastroretentive Amoxicillin Floating Tablets Employing a Specific Design of the Flow-Through Cell

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