Comparison of DOPA and DPPA liposome templates for the synthesis of calcium phosphate nanoshells

Yeo, C. H.; Zein, Sharif Hussein Sharif; Ahmad, A.L.; McPhail, David S.

doi:10.1016/j.ceramint.2011.07.044

Cited by 23 publications

(23 citation statements)

References 41 publications

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“…Indeed, precipitated HA crystals are generally very small and hence present very large specific surface areas (typically above 50m 2 /g 110 - 115 ). Moreover, HA has excellent adsorption properties, which explains its use in chromatography 116 - 118 …”

Section: Consolidation Methodsmentioning

confidence: 99%

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

et al. 2013

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Calcium phosphate materials have been used increasingly in the past 40 years as bone graft substitutes in the dental and orthopedic fields. Accordingly, numerous fabrication methods have been proposed and used. However, the controlled production of spherical calcium phosphate particles remains a challenge. Since such particles are essential for the synthesis of pastes and cements delivered into the host bone by minimally-invasive approaches, the aim of the present document is to review their synthesis and applications. For that purpose, production methods were classified according to the used reagents (solutions, slurries, pastes, powders), dispersion media (gas, liquid, solid), dispersion tools (nozzle, propeller, sieve, mold), particle diameters of the end product (from 10 nm to 10 mm), and calcium phosphate phases. Low-temperature calcium phosphates such as monetite, brushite or octacalcium phosphate, as well as high-temperature calcium phosphates, such as hydroxyapatite, β-tricalcium phosphate or tetracalcium phosphate, were considered. More than a dozen production methods and over hundred scientific publications were discussed.

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Section: Consolidation Methodsmentioning

confidence: 99%

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

et al. 2013

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“…Variation of shell thickness and stoichiometry may be a way of manipulating the dissolution kinetics of ACP coating to control the release of encapsulated materials, necessary for drug delivery purposes [541,542]. Other types of calcium orthophosphate shells with Ca/P ratios of 0.97 (DCPD or DCPD-like ACP) and 1.45 (CDHA or ACP) were prepared using liposome templates [543]. Roughly spherical DCPA particles of approx.…”

Section: Other Nanodimensional and Nanocrystalline Calcium Orthophospmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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“…The mean particle sizes of the CaP nanoshells were in the range of 173.6 ± 2.1 to 427.8 ± 77.9 nm. The results show the growth of CaPs on the DOPA template: larger mean particle sizes were observed for the samples of CaP nanoshells compared with the DOPA template (64.7 ± 0.7 nm) (Yeo et al, 2012). The difference in mean particle sizes between sample C-DOPA-4 (best qualitative result) and the DOPA template determined by the DLS method represents the mean nanoshell thickness, which is 132.8 nm.…”

Section: Morphological Analysismentioning

confidence: 78%

“…Compared with the bare DOPA liposomes (-75.3 ± 2.9 mV) (Yeo et al, 2012) , the magnitudes of all the zeta potentials decreased after the growth of CaPs on the liposomes. The growth of CaPs on the liposomes clearly affected the zeta potential of the template.…”

Section: Polydispersity Indexmentioning

confidence: 99%

Investigation into the role of NaOH and calcium ions in the synthesis of calcium phosphate nanoshells

Yeo

Zein

Ahmad

et al. 2012

Braz. J. Chem. Eng.

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-Calcium phosphate (CaP) nanoshells were prepared using negatively charged liposomes (1,2-dioleoyl-sn-glycero-3-phosphate sodium salt (DOPA)) as a template by base titration synthesis at various concentrations of NaOH and calcium ions. The elemental composition, morphology, particle size, particle size distribution and zeta potential of the products were determined via various characterisation techniques, such as energy-dispersive X-ray spectrometry (EDX), transmission electron microscopy (TEM), dynamic light scattering (DLS), laser Doppler velocimetry (LDV) and Fourier transform infrared spectroscopy (FTIR). The best results showed that stable spherical CaP nanoshells with a mean particle size of 197.5 ± 5.8 nm and a zeta potential of -34.5 ± 0.6 mV were successfully formed when 0.100 M sodium hydroxide (NaOH) and 0.100 M calcium ions were used. Moreover, an optimal pH of 10.52 and a final Ca/P molar ratio of 0.97 were achieved under these conditions.

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Comparison of DOPA and DPPA liposome templates for the synthesis of calcium phosphate nanoshells

Cited by 23 publications

References 41 publications

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Investigation into the role of NaOH and calcium ions in the synthesis of calcium phosphate nanoshells

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