Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase

Akiyama, Shinichiro; Inagaki, Masumi; Tsuji, Mayumi; Gotoh, Hiromichi; Gotoh, Tomomi; Washio, Kazunori; Gotoh, Y; Oguchi, Katsuji

doi:10.1159/000088172

Cited by 19 publications

(20 citation statements)

References 53 publications

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“…29,30 This condition has been demonstrated to contribute to the pathogenesis of various complications such as cardiovascular diseases, beta-2 microglobulinamyloidosis and protein malnutrition. To cope with this problem, dialyzers have been evolved into more biofriendly devices.…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Huang

et al. 2015

Renal Failure

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Background: This was controversial whether vitamin E-coated dialyzer therapy was beneficial for the complications associated with hemodialysis. Therefore, we performed this systematic review to evaluate the effects of vitamin E-coated dialyzer. Methods: Related trials were searched from multiple electronic databases. We conducted meta-analysis to assess changes in the predefined outcomes using RevMan 5.3 software. Results: Meta-analysis showed vitamin E-coated dialyzer therapy could decrease erythropoietin (EPO) resistance index (SMD, À0.24; 95% CI, À0.47 to À0.01; p ¼ 0.04). However, pooled-analysis showed vitamin E-coated dialyzer therapy could not decrease weekly EPO dose (SMD, À0.11; 95% CI, À0.32 to 0.09; p ¼ 0.28) and intima-media thickness (IMT) of the carotid artery (MD, À0.09; 95% CI, À0.2 to 0.01; p ¼ 0.09), and vitamin E-coated dialyzer therapy did not improve the serum hemoglobin (MD, À0.03; 95% CI, À0.18 to 0.13; p ¼ 0.74), albumin levels (SMD, À0.64; 95% CI, À1.62 to 0.34; p ¼ 0.2), in addition, there was no significant difference in serum cholesterol (SMD, À0.07; 95% CI, À0.45 to 0.31; p ¼ 0.71), triglycerides (MD, À2.77; 95% CI, À32.42 to 26.87; p ¼ 0.85), high density lipoprotein (HDL) (SMD, 0.24; 95% CI, À0.14 to 0.62; p ¼ 0.22) and low density lipoprotein (LDL) (SMD, 0.00; 95% CI, À0.38 to 0.37; p ¼ 0.98) levels. Conclusions: Vitamin E-coated dialyzer may reduce the EPO resistance, but there is no conclusive evidence that vitamin E-coated dialyzer can improve the renal anemia, malnutrition, dyslipidemia and atherosclerosis status in hemodialysis (HD) patients. However, high-quality trials with hard clinical endpoints are required to fully elucidate the clinical value of vitamin E-coated dialyzer therapy.

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Section: Discussionmentioning

confidence: 99%

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Huang

et al. 2015

Renal Failure

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“…Some studies have indicated a possible benefit of vitamin E supplementation in cardiovascular risk reduction in patients with ESRD [39], and both vitamin E supplementation and the use of vitamin E-coated dialyzers have been shown to decrease oxidant stress in these patients [40]. However, vitamin E levels in predialysis patients with CKD have only been studied in a few previous reports.…”

Section: Discussionmentioning

confidence: 99%

Increase in Oxidative Stress but Not in Antioxidant Capacity with Advancing Stages of Chronic Kidney Disease

Karamouzis¹,

Sarafidis

Karamouzis³

et al. 2007

Am J Nephrol

103

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Background/Aims: Increased oxidative stress in chronic kidney disease (CKD) was suggested to be both a cause and an effect of renal injury. However, the evolution of oxidant stress from early stages of renal function decline is not fully clear. This study aimed to determine the oxidant-antioxidant balance across the whole range of renal function. Methods: A total of 116 patients with CKD (85 predialysis patients divided into groups according to CKD stage, and 31 patients with end-stage renal disease (ESRD) on hemodialysis treatment), as well as 29 healthy subjects were evaluated. Plasma levels of 15-F_2t-isoprostane (15-F_2t-IsoP), a valid marker of oxidant stress, as well as total antioxidant capacity (TAC) and serum levels of vitamin E were measured in all participants. Results: Plasma 15-F_2t-IsoP levels were higher in predialysis and ESRD patients compared to healthy subjects and were progressively increasing with advancing CKD stages (p < 0.001). In contrast, plasma TAC was similar between healthy subjects and predialysis patients, and presented a small reduction in ESRD patients (p < 0.001). Vitamin E levels were higher in healthy subjects compared to any other group (p < 0.001) and slightly higher in ESRD patients compared to predialysis patients (p < 0.01), but did not differ significantly between the groups of predialysis patients. Plasma 15-F_2t-IsoP levels were inversely correlated with estimated glomerular filtration rate in predialysis patients (r = –0.65, p < 0.001). Conclusions: This study shows that 15-F_2t-IsoP levels increase progressively with advancing CKD stages, whereas TAC and vitamin E levels remain rather stable with the loss of renal function and change only in patients with ESRD.

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“…At the same time, we showed that the increase in plasma Cu/Zn-SOD levels is accompanied by enhanced expression of mRNA of Cu/Zn-SOD within leukocytes, demonstrating that the increased Cu/Zn-SOD level is not only due to the increased elimination insufficiency, but also due to the increase in its production [13]. Furthermore, we observed [15] that when lipid-soluble antioxidant vitamin E is orally given to hemodialysis patients, the plasma Cu/Zn-SOD level, used as an oxidative stress marker, was found to be reduced. Also, when a vitamin E-modified dialysis membrane was used, a similar decrease in plasma Cu/Zn-SOD level was observed, suggesting that the increase in plasma Cu/Zn-SOD was induced specifically by the hemodialysis process [15].…”

Section: Introductionmentioning

confidence: 89%

“…Furthermore, we observed [15] that when lipid-soluble antioxidant vitamin E is orally given to hemodialysis patients, the plasma Cu/Zn-SOD level, used as an oxidative stress marker, was found to be reduced. Also, when a vitamin E-modified dialysis membrane was used, a similar decrease in plasma Cu/Zn-SOD level was observed, suggesting that the increase in plasma Cu/Zn-SOD was induced specifically by the hemodialysis process [15]. …”

Section: Introductionmentioning

confidence: 99%

Oral Vitamin C Supplementation in Hemodialysis Patients and Its Effect on the Plasma Level of Oxidized Ascorbic Acid and Cu/Zn Superoxide Dismutase, an Oxidative Stress Marker

et al. 2008

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Background/Aim: Oxidative stress is known to be enhanced in hemodialysis patients, and one of its useful markers is plasma copper/zinc superoxide dismutase (Cu/Zn-SOD). The increase in plasma Cu/Zn-SOD can be inhibited by orally administered lipid-soluble vitamin E. We examined the antioxidative effects of water-soluble vitamin C administered orally on Cu/Zn-SOD levels in hemodialysis patients. Methods: Vitamin C was orally administered to 16 maintenance hemodialysis patients before each dialysis session. Doses were increased from 200 to 1,000 mg over 3 months. The levels of plasma vitamin C and Cu/Zn-SOD and its mRNA expression in leukocytes were determined 1, 2, and 3 months after the start of vitamin C administration. Furthermore, the levels of oxidized and reduced forms of plasma vitamin C were determined before the start of vitamin C administration and before and after dialysis at 1,000-mg vitamin C doses. Results: Following oral administration, the plasma levels of vitamin C and its oxidized form were increased. However, significant changes in plasma Cu/Zn-SOD or its mRNA expression in leukocytes were not observed. Conclusion: In maintenance hemodialysis patients, vitamin C administration resulted in a significant increase in the postdialysis level of the oxidized form of vitamin C, which suggested an increase in antioxidant effect. However, water-soluble vitamin C did not significantly suppress Cu/Zn-SOD expression enhancement.

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Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase

Cited by 19 publications

References 53 publications

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Increase in Oxidative Stress but Not in Antioxidant Capacity with Advancing Stages of Chronic Kidney Disease

Oral Vitamin C Supplementation in Hemodialysis Patients and Its Effect on the Plasma Level of Oxidized Ascorbic Acid and Cu/Zn Superoxide Dismutase, an Oxidative Stress Marker

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