Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor

Baykal, Baran Özhan; Avcıoğlu, Sümeyra Nergiz

doi:10.5152/jtgga.2015.15156

Cited by 8 publications

(9 citation statements)

References 25 publications

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“…This is consistent with the study done by Baykal and Avcıoğlu where they did not find any significant difference in Doppler ultrasonography measurements of UtA or between Doppler indices for MCA at 2 h (early phase) and 48 h (late phase) after nifedipine treatment (p>0.05). 17 Our data showed that nifedipine tocolysis produced no differences in the umbilical arteries Doppler (RI and PI) or in the MCA to umbilical artery ratio, similar to the findings of Karahanoglu et al who found that RI, the PI and the S/D ratio of UA did not change after treatment with nifedipine. 18 Also, de Heus et al showed that over the 5-day study period.…”

Section: Discussionsupporting

confidence: 91%

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Abdellateef¹,

Shorbagy²,

Hagras³

et al. 2017

Gynecol Obstet Res Open J

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CitationAbdellateef SS, El Shorbagy SH, Hagras AM, Ghareeb AE. Assessment of maternal nifedipine as a tocolytic agent on the Doppler indices of uterine and fetal umbilical and middle cerebral arteries. This study was designed to assess the effects of maternal nifedipine administration on blood flow resistance in uterine, umbilical and fetal middle cerebral arteries by evaluating resistance index (RI) and pulsatility index (PI). Patients and Methods: This was a prospective, observational, analytic cohort study performed in 50 pregnant women undergoing nifedipine tocolysis, all women with a singleton pregnancy between 24 and 34 weeks of gestation, each subject acting as her own control. Doppler assessment of uterine, umbilical and fetal middle cerebral (MCA) arteries was performed before and 24 h and 72 h after an initial 20 mg oral dose, which was repeated at 20 min intervals if contractions failed to diminish up to a total maximum dose of 60 mg. The maintenance dose consisted of 20 mg orally every 6 h. We analyzed whether there was a time effect and compared values at the different time-points. Results: The research showed that the UtA-RI has increased significantly after 24 h and after 72 h of nifedipine administration (0 h=0.53; 24 h=0.56; 72 h=0.55; p=0.002, p=0.015 respectively). The MCA-RI had decreased significantly after 24 h (p=0.003) of tocolysis returning to baseline after 72 h (0 h=0.75; 24 h=0.73; 72 h=0.74; p=0.150). The MCA-PI had decreased significantly after 24 h (P=0.024) of tocolysis returning to baseline between 24 h and 72 h (0 h=1.85; 24 h=1.75; 72 h=1.79; p=0.204), with no differences in UtA-PI or in the umbilical arteries Doppler (RI & PI) or in the MCA to umbilical artery ratio. Conclusions: Nifedipine tocolysis is associated with a reduction in RI and PI in the MCA, and an increase in RI in uterine arteries after 24 h but returning to baseline within 72 h, with no long-term effect on fetomaternal circulation in pregnant women at risk of preterm delivery.

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Section: Discussionsupporting

confidence: 91%

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Abdellateef¹,

Shorbagy²,

Hagras³

et al. 2017

Gynecol Obstet Res Open J

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“…Several studies have investigated the possible effects of nifedipine on fetomaternal blood flow . Two previous studies reported that nifedipine does not cause a significant change in uteroplacental and fetal Doppler parameters. These two studies evaluated patients in preterm labor who had received an oral nifedipine loading dose, followed by maintenance therapy.…”

Section: Discussionmentioning

confidence: 99%

“…These two studies evaluated patients in preterm labor who had received an oral nifedipine loading dose, followed by maintenance therapy. In one of these studies, the patients also received betamethasone. Two other studies showed significant effects of nifedipine on maternal and fetal vessels.…”

Section: Discussionmentioning

confidence: 99%

Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

İnan

Sayın

Dolgun

et al. 2018

Intl J Gynecology & Obste

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“…Based on these results it can be concluded that administration of nifedipine does not affect the welfare of the fetus, and does not cause any signs of placental insu ciency. 34 DV PI changes in blood ow before and after hours after nifedipine therapy Table 4.3 showed the mean DV PI before therapy was 0.50 ± 0.17, while the mean of DV PI after nifedipine therapy for 48 hours was 0.50 ± 0.18 without any signi cancy. The DV is a blood vessel that has a thin muscle.…”

Section: Nomentioning

confidence: 97%

“…Applying nifedipine does not cause redistribution of blood ow to the cerebral. 34 Changes in CPR PI blood ow before and after 48 hours after nifedipine therapy…”

Section: Nomentioning

confidence: 99%

The Impact of Nifedipine on Maternal and Fetal Blood Stream on the Threat of Preterm Labor: an Experimental Study

Anwar

Tiara

Anggraeni

et al. 2020

Preprint

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Background: Preterm birth is a significant cause of perinatal morbidity and mortality and that becomes a major challenge in perinatal health care. Various pharmacological agents that inhibit uterine contractions are used in clinical practice to prevent preterm delivery. The maternal and fetal side-effect profiles of tocolytic agents are becoming an important consideration in selecting the drug of choice. Nifedipine, a dihydropyridine calcium entry blocker, is an effective tocolytic agent with low toxicity and teratogenicity, while carrying potential maternal as well as fetal vascular side effects due to its action on vascular smooth muscle. This study was performed to asses nifedipine use as tocolytic agent in preventing preterm birth, and assesing maternal as well as fetal vascular side effects.Methods: This experimental study with one-group pretest-posttest design was performed in 30 pregnant women undergoing nifedipine as tocolytic. Doppler assessment of uterine, umbilical and fetal middle cerebral arteries, ductus venosus, and cerebroplacental ratio was performed before and 48 hours after nifedipine therapy. Wilcoxon's signed ranks test was used to analyze the difference between the two variables. A P-value of < 0.05 was considered significant.Results: The result of the study showed nifedipine was associated with a significant decreased of pulsatility index uterine artery (p = 0.016; p-value<0.05) and umbilical artery (p = 0.037; p-value<0.05) after 48 hours therapy, while pulsatility index of fetal middle cerebral arteries, ductus venosus, and cerebroplacental ratio did not change significantly.Conclusion: The study concluded that nifedipine as tocolytic increased blood flow of uterine artery and umbilical artery after 48 hours therapy.

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Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor

Cited by 8 publications

References 25 publications

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

The Impact of Nifedipine on Maternal and Fetal Blood Stream on the Threat of Preterm Labor: an Experimental Study

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