Comparison of effects of stimulation of Deiters' nucleus and medial longitudinal fasciculus on neck, forelimb, and hindlimb motoneurons.

Wilson, Victor J.; Yoshida, Masafumi

doi:10.1152/jn.1969.32.5.743

Cited by 391 publications

(77 citation statements)

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“…Reticulospinal neurons have very strong actions upon neck motoneurons (Wilson and Yoshida 1969), and an involvement of reticulospinal neurons as relay neurons for disynaptic actions from the motor cortex was demonstrated in a two-step experiment: first, showing that the cortical actions remained unchanged after transection of the PTs in the caudal medulla, removing the spinal actions of the corticospinal fibers; and second, showing that they disappeared after a more rostral transection of the pyramid that disrupted corticospinal connections with medullary reticulospinal neurons (Alstermark and others 1985).…”

Section: Actions Mediated Via Ipsilaterally Descending Reticulospinalmentioning

confidence: 99%

How Can Corticospinal Tract Neurons Contribute to Ipsilateral Movements? A Question With Implications for Recovery of Motor Functions

2006

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In this review, the authors discuss some recent findings that bear on the issue of recovery of function after corticospinal tract lesions. Conventionally the corticospinal tract is considered to be a crossed pathway, in keeping with the clinical findings that damage to one hemisphere, for example, in stroke, leads to a contralateral paresis and, if the lesion is large, a paralysis. However, there has been great interest in the possibility of compensatory recovery of function using the undamaged hemisphere. There are several substrates for this including ipsilaterally descending corticospinal fibers and bilaterally operating neuronal networks. Recent studies provide important evidence bearing on both of these issues. In particular, they reveal networks of neurons interconnecting two sides of the gray matter at both brainstem and spinal levels, as well as intrahemispheric transcallosal connections. These may form "detour circuits" for recovery of function, and here the authors will consider some possibilities for exploiting these networks for motor control, even though their analysis is still at an early stage.

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Section: Actions Mediated Via Ipsilaterally Descending Reticulospinalmentioning

confidence: 99%

How Can Corticospinal Tract Neurons Contribute to Ipsilateral Movements? A Question With Implications for Recovery of Motor Functions

2006

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“…This is thought to be achieved through the extensive branching of reticulospinal axons (Peterson et al, 1975;Matsuyama et al, 1993Matsuyama et al, , 1997Sasaki, 1997), allowing them to exert widespread direct and indirect actions on spinal motoneurons (MNs) Shapovalov, 1969;Wilson and Yoshida, 1969;Peterson, 1979;Peterson et al, 1979;Sasaki, 1999;Habaguchi et al, 2002;Jankowska et al, 2003;Riddle et al, 2009). However, the identities of the spinal interneurons (INs) that mediate reticulospinal actions on MNs remain elusive (for surveys of reticulospinal actions on interneurons identified by proprioceptive inputs, see Jankowska, 1992;Jankowska and Edgley, 2010).…”

Section: Introductionmentioning

confidence: 99%

Organization of Functional Synaptic Connections between Medullary Reticulospinal Neurons and Lumbar Descending Commissural Interneurons in the Neonatal Mouse

Szokol¹,

Glover²,

Perreault³

2011

J. Neurosci.

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The medullary reticular formation (MRF) of the neonatal mouse is organized so that the medial and lateral MRF activate hindlimb and trunk motoneurons (MNs) with differential predominance. The goal of the present study was to investigate whether this activation is polysynaptic and mediated by commissural interneurons with descending axons (dCINs) in the lumbar spinal cord. To this end, we tested the polysynapticity of inputs from the MRF to MNs and tested for the presence of selective inputs from medial and lateral MRF to 574 individual dCINs in the L2 segment of the neonatal mouse.Reticulospinal-mediated postsynaptic Ca 2ϩ responses in MNs were reduced in the presence of mephenesin and after a midline lesion, suggesting the involvement of dCINs in mediating the responses. Consistent with this, stimulation of reticulospinal neurons in the medial or lateral MRF activated 51% and 57% of ipsilateral dCINs examined (255 and 352 dCINs, respectively) and 52% and 46% of contralateral dCINs examined (166 and 133 dCINs, respectively). The proportion of dCINs that responded specifically to stimulation of medial or lateral MRF was similar to the proportions of dCINs that responded to both MRF regions or to neither. The three responsive dCIN populations had largely overlapping spatial distributions.We demonstrate the existence of dCIN subpopulations sufficient to mediate responses in lumbar motoneurons from reticulospinal pathways originating from the medial and lateral MRF. Differential control of trunk and hindlimb muscles by the medullary reticulospinal system may therefore be mediated in part by identifiable dCIN populations.

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“…However, the spinal neuronal networks via which they act have been studied to a much smaller extent in mammals than in lower vertebrates. In the feline spinal cord, attention has been focused on ipsilateral neuronal networks (Lund and Pompeiano, 1965;Grillner et al, 1968;Lund and Pompeiano, 1968;Shapovalov, 1969;Wilson and Yoshida, 1969;Floeter et al, 1993). The actions of reticulospinal tract neurons on contralateral neurons have hardly been analyzed, even when reported (Floeter et al, 1993;Habaguchi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…The first was whether reticulospinal neurons induce monosynaptic EPSPs in contralateral lumbar motoneurons. The second was whether any disynaptic EPSPs or IPSPs are induced in these neurons as a counterpart of disynaptic reticulospinal actions on ipsilateral motoneurons (Lund and Pompeiano, 1965;Grillner et al, 1968;Lund and Pompeiano, 1968;Shapovalov, 1969;Wilson and Yoshida, 1969), and the third was to what extent any disynaptic PSPs evoked in contralateral motoneurons might be mediated by lamina VIII commissural neurons. Lamina VIII interneurons constitute the main group of neurons forming synaptic contacts with contralateral motoneurons (Scheibel and Scheibel, 1966;Harrison et al, 1986;Alstermark and Kummel, 1990;Hoover and Durkovic, 1992).…”

Section: Introductionmentioning

confidence: 99%

Neuronal Basis of Crossed Actions from the Reticular Formation on Feline Hindlimb Motoneurons

et al. 2003

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Comparison of effects of stimulation of Deiters' nucleus and medial longitudinal fasciculus on neck, forelimb, and hindlimb motoneurons.

Cited by 391 publications

References 0 publications

How Can Corticospinal Tract Neurons Contribute to Ipsilateral Movements? A Question With Implications for Recovery of Motor Functions

How Can Corticospinal Tract Neurons Contribute to Ipsilateral Movements? A Question With Implications for Recovery of Motor Functions

Organization of Functional Synaptic Connections between Medullary Reticulospinal Neurons and Lumbar Descending Commissural Interneurons in the Neonatal Mouse

Neuronal Basis of Crossed Actions from the Reticular Formation on Feline Hindlimb Motoneurons

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