Comparison of effects of sustained isocapnic hypoxia on ventilation in men and women

Sajkov, Dimitar; Neill, Alister; Saunders, Nicholas A.; Rd, McEvoy

doi:10.1152/jappl.1997.83.2.599

Cited by 22 publications

(17 citation statements)

References 31 publications

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“…Other studies found an HVR that was greater in men compared to women, with a range of 39–110% [15,16,17]. There also are data showing no gender difference [18,19, 20]. Prior studies evaluated between 11 to 67 subjects in total, in comparison to the 427 participants with reliable data in our study.…”

Section: Discussionsupporting

confidence: 64%

Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers

Goldberg

Ollila

et al. 2017

PLoS ONE

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IntroductionA previous study has suggested that the Human Leukocyte Antigen (HLA) allele DQB1*06:02 affects hypoxic ventilatory response (HVR) but not hypercapnic ventilatory response (HCVR) in an Asian population. The current study evaluated the relationship in Caucasians and Asians. In addition we assessed whether gender or polymorphisms in genes participating in the control of breathing affect HVR and HCVR.MethodsA re-breathing system was used to measure HVR and HCVR in 551 young adults (56.8% Caucasians, 30% Asians). HLA-DQB1*06:02 and tagged polymorphisms and coding variants in genes participating in breathing (PHOX2B, GPR4 and TASK2/KCNK5) were analyzed. The associations between HVR/HCVR and HLA-DQB1*06:02, genetic polymorphisms, and gender were evaluated using ANOVA or frequentist association testing with SNPTEST.ResultsHVR and gender are strongly correlated. HCVR and gender are not. Mean HVR in women was 0.276±0.168 (liter/minute/%SpO2) compared to 0.429±0.266 (liter/minute/%SpO2) in men, p<0.001 (55.4% higher HVR in men). Women had lower baseline minute ventilation (8.08±2.36 l/m vs. 10.00±3.43l/m, p<0.001), higher SpO2 (98.0±1.3% vs. 96.6±1.7%, p<0.001), and lower EtCO2 (4.65±0.68% vs. 4.82±1.02%, p = 0.025). One hundred and two (18.5%) of the participants had HLA-DQB1*06:02. No association was seen between HLA-DQB1*06:02 and HVR or HCVR. Genetic analysis revealed point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and HCVR.ConclusionsThis is the largest study to date reporting the relationship between gender and HVR/ HCVR and the first study assessing the association between genetic polymorphisms in humans and HVR/HCVR. The data suggest that gender has a large effect on hypoxic breathing response.

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Section: Discussionsupporting

confidence: 64%

Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers

Goldberg

Ollila

et al. 2017

PLoS ONE

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“…Wenninger studied the effects of age and sex on HVR in rats and reported a greater HVR in females than in males 20 months old (Wenninger et al 2009). Regardless of age, a majority of authors found no difference in HVR between the sexes (Sajkov et al 1997; Teppema & Dahan, 2010). In women, an enhancement of HVR was described during the luteal phase compared with the follicular phase (Schoene et al 1981; White et al 1983) and during pregnancy (Moore et al 1987; Hannhart et al 1989).…”

Section: Discussionmentioning

confidence: 96%

Ageing and cardiorespiratory response to hypoxia

Lhuissier

Canouï‐Poitrine

Richalet

2012

The Journal of Physiology

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Key points• A previous study showed that an older age could be associated with a lower risk of severe altitude-induced diseases.• This work combines a cross-sectional study including 4675 subjects and a longitudinal study on 30 subjects.• It shows that ageing is associated with a blunting of cardiac chronotropic function and an increase in ventilatory response leading to maintenance of arterial O 2 saturation in hypoxia.• These adaptive responses to hypoxia with ageing are blunted by menopause but can be maintained with endurance training.• The cardiac and ventilatory adaptations allow older people to challenge hypoxia similarly to younger ones when performing moderate exercise. AbstractThe risk of severe altitude-induced diseases is related to ventilatory and cardiac responses to hypoxia and is dependent on sex, age and exercise training status. However, it remains unclear how ageing modifies these physiological adaptations to hypoxia. We assessed the physiological responses to hypoxia with ageing through a cross-sectional 20 year study including 4675 subjects (2789 men, 1886 women; 14-85 years old) and a longitudinal study including 30 subjects explored at a mean 10.4 year interval. The influence of sex, training status and menopause was evaluated. The hypoxia-induced desaturation and the ventilatory and cardiac responses to hypoxia at rest and exercise were measured. In men, ventilatory response to hypoxia increased (P < 0.002), while desaturation was less pronounced (P < 0.001) with ageing. Cardiac response to hypoxia was blunted with ageing in both sexes (P < 0.001). Similar results were found in the longitudinal study, with a decrease in cardiac and an increase in ventilatory response to hypoxia with ageing. These adaptive responses were less pronounced or absent in post-menopausal women (P < 0.01). At exercise, desaturation was greater in trained subjects but cardiac and ventilatory responses to hypoxia were preserved by training, especially in elderly people. In conclusion, respiratory response to hypoxia and blood oxygenation improve with ageing in men while cardiac response is blunted with ageing in both sexes. Training aggravates desaturation at exercise in hypoxia, improves the ventilatory response and limits the ageing-induced blunting of cardiac response to hypoxia. Training limits the negative effects of menopause in cardiorespiratory adaptations to hypoxia. Abbreviations BP, blood pressure; S aO 2 ,e , desaturation at exercise; S aO 2 ,r , desaturation at rest; eh, exercise in hypoxia; en, exercise in normoxia; HCR, cardiac response to hypoxia; HVR, ventilatory response to hypoxia; HCR e , HVR e , cardiac and ventilatory response to hypoxia at exercise; HCR r , HVR r , cardiac and ventilatory response to hypoxia at rest; HR, heart rate; PO, power output; rh, rest in hypoxia; rn, rest in normoxia; S aO 2 , arterial O 2 saturation; SHAI, severe high-altitude illness;V E , minute ventilation.

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“…Wenninger studied the effects of age and gender on HVR in rats and reported a greater HVR in females than in males at old age (Wenninger et al, 2009). Regardless of age, a majority of authors found no difference in HVR between genders (Sajkov et al, 1997;Teppema and Dahan, 2010). In women, an enhancement of HVR was described during the luteal phase compared to the follicular phase (Schoene et al, 1981;White et al, 1983) and during pregnancy (Moore et al, 1987;Hannhart et al, 1989).…”

Section: Menopause and Ventilatory Responsementioning

confidence: 99%

Aging, Tolerance to High Altitude, and Cardiorespiratory Response to Hypoxia

Richalet

Lhuissier

2015

High Altitude Medicine & Biology

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Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude, and cardiorespiratory response to hypoxia. High Alt Med Biol. 16:117-124, 2015.--It is generally accepted that aging is rather protective, at least at moderate altitude. Some anecdotal reports even mention successful ascent of peaks over 8000 m and even Everest by elderly people. However, very few studies have explored the influence of aging on tolerance to high altitude and prevalence of acute high altitude related diseases, taking into account all confounding factors such as speed of ascent, altitude reached, sex, training status, and chemo-responsiveness. Changes in physiological responses to hypoxia with aging were assessed through a cross-sectional 20-year study including 4675 subjects (2789 men, 1886 women; 14-85 yrs old) and a longitudinal study including 30 subjects explored at a mean 10.4-year interval. In men, ventilatory response to hypoxia increased, while desaturation was less pronounced with aging. Cardiac response to hypoxia was blunted with aging in both genders. Similar results were found in the longitudinal study, with a decrease in cardiac and an increase in ventilatory response to hypoxia with aging. These adaptive responses were less pronounced or absent in post-menopausal untrained women. In conclusion, in normal healthy and active subjects, aging has no deleterious effect on cardiac and ventilatory responses to hypoxia, at least up to the eighth decade. Aging is not a contraindication for high altitude, as far as no pathological condition interferes and physical fitness is compatible with the intensity of the expected physical demand of one's individual. Physiological evaluation through hypoxic exercise testing before going to high altitude is helpful to detect risk factors of severe high altitude-related diseases.

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Comparison of effects of sustained isocapnic hypoxia on ventilation in men and women

Cited by 22 publications

References 31 publications

Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers

Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers

Ageing and cardiorespiratory response to hypoxia

Aging, Tolerance to High Altitude, and Cardiorespiratory Response to Hypoxia

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