Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells

Abstract

AbstrakBackground: Oligonol ® (OLG) is raw materials for functional foods or cosmetics which contains low-molecular-weight polyphenols derived from lychee fruit (Litchi chinensis Sonn.). It has been reported to many functions such as antiinflammatory and anti-oxidants. Aim: In this study, with the aim of exploring new functionalities of OLG on the scalp and hair growth, we investigate i ts effect on human dermal papilla cells (HDPC) by comparing it with adenosine and minoxidil at the genetic level. Method: OLG, adenosine, and minoxidil were applied to HDPC culture lines for 24 h, after which VEGF, FGF-7, WNT5a, and WNT10a mRNA expression was measured by real-time PCR analysis. Additionally, using DNA microarrays, we investigated their effects on 205 inflammation-related genes. Result: The FGF-7, and WNT10a mRNA expression were observed in HDPC added with OLG. The results of the DNA microarray analysis showed that the expression of 11 genes was suppressed by OLG. These functions of OLG on HDPC were not the same as adenosine and minoxidil. Conclusions: OLG may affect the function of HDPC by regulating the expression of genes related to cell proliferation and inflammation.

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

“…The research on herbs and active constituents as hair growth promoters has been driven by their less toxicity, easy availability, low‐cost, patient compliance and more than one mode of biochemical action . Specific effects of herbal extracts, polyherbal formulations, flavonoids and natural compounds on DPCs have been examined . In vivo hair growth promoting effects as proof of concept are also mentioned.…”

Hair Growth Effect of TS-SCLF from Schisandra chinensis Extract Fermented with Lactobacillus plantarum

“…KGF and HGF have been reported as peripherally secreted growth factors that promote hair growth [31,32]. KGF/FGF-7 was 68.70 pg/ml in the control group and 97.52 pg/ml in the minoxidil 30 μM treatment group, which was 41.94% higher in the minoxidil-treated group (Fig.…”

“…Growth factors, such as fibroblast growth factor-1 (FGF-1), -2, -7, and -10 and epidermal growth factor (EGF), also promote cell cycle proliferation, improve hair loss, and promote hair cell regeneration, both in and outside the body [31,32]. TGF-β1 is known for inducing hair loss by interfering with hair follicle growth and causing entrance into the catagen stage faster than normal [33− 35].…”