Comparison of Efficacy of Ondansetron Pre-treatment in Alleviating Pain due to Propofol during General Anaesthesia with Placebo

Abstract

Background: Ondansetron is a 5HT3 receptor blocker and has multifaceted action like sodium channel blocker and µ - opioid agonist. Objective: To compare the efficiency of ondansetron pre-treatment in alleviating pain caused by propofol during induction of general anaesthesia with placebo. Material & Method: In this randomized controlled trail 120 patients of ASA grade I & II undergoing elective surgery were included and divided into two equal groups A & B by using lottery method. Each group comprised of 60 patients. In group A two ml 0.9 % normal saline and in group B, 2 ml ondansetron (4mg) given intravenously. In both groups propofol was given in a dose of 2.5 mg / Kg intravenously. Results: The mean age of patients in group A was 29.95 ± 4.79 year and in group B was 30.30 ± 4.87 year. Majority of patients 67(55.83 %) were between 18 to 30 year of age. Out of 120 patients. 63 (52.50 %) were ASA I & 52 (47.50 %) were ASA II. Efficacy of group A (placebo) was seen in 11 (18.33 %) while in group B (ondansetron) was seen in 56 (93.33 %). Conclusion: Ondansetron pre-treatment in alleviating pain cause by propofol is very effective. Keywords: Pain, ondansetron, propofol, general anaesthesia.

Effect of ondansetron compared to lidocaine and placebo for reducing propofol injection pain: A systematic review and meta-analysis of randomized controlled trials

“…The full-text screening was performed on 35 studies. Finally, 23 studies were included in the qualitative analysis, [11,13,[16][17][18][19][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] of which 20 studies were included in the quantitative analysis. [11,13,[16][17][18][19][23][24][25][26][27][28][29][30][31][32][33][34][35][36] The study selection procedure is shown in Figure 1 by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement flow chart.…”

“…A recent trial with 120 participants by Zahra et al [ 38 ] showed that ondansetron significantly reduced pain compared to placebo. Also, Powell et al [ 37 ] reported that pretreatment with 8 mg ondansetron decreased the post-anesthetic shivering incidence in adults without affecting temperature distribution during general anesthesia.…”

“…The mean age of the included participants was 39.49 years. Of the included studies, ondansetron was compared with placebo in 21 studies, [11,13,[16][17][18][19]23,24,[27][28][29][30][31][32][33][34][35][36][37][38][39] and compared with lidocaine in 6 studies. [19,25,26,28,31,33] Patients' baseline characteristics and a summary of the included studies are provided in Tables 1 and 2.…”