Comparison of efficiency of photodynamic diagnostics with topical use of the 3% and 15% aminolevulinic acid in the detection of vulvar lesions

Maździarz, Agnieszka; Zielińska, Aleksandra; Alkhalayla, Habib; Śpiewankiewicz, Beata

doi:10.1016/j.pdpdt.2013.03.012

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…compared vulvar lesions using two 5-ALA concentrations to assess results of histological examinations. All results showed a high correlation between the PDD method and vulvar lesions with the accuracy of histological examination ( 280 ).…”

Section: Review Of the Literaturementioning

confidence: 87%

“…In patients with periodontitis with rapid progression and severe severity, photodynamic therapy improves the clinical condition, but should not be used as a substitute for amoxicillin and metronidazole (275). PDT causes a significant reduction of bacteria, but their complete elimination is usually not achieved (276)(277)(278)(279)(280)(281)(282)(283)(284)(285)(286)(287). It is also important to use the most selective photosensitizers possible, because killing the entire physiological flora of the oral cavity exposes patients to infections with opportunistic pathogens (276).…”

Section: -Ala Clinical Ester Methyl Aminolevulinate (Mal) Clinicalmentioning

confidence: 99%

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The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation to induce cancer cell death. With a history spanning over decades, PDT’s dynamic evolution has expanded its application across dermatology, oncology, and dentistry. This review aims to dissect PDT’s principles, from its inception to contemporary medical applications, highlighting its role in modern cancer treatment strategies.

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Section: Review Of the Literaturementioning

confidence: 87%

Section: -Ala Clinical Ester Methyl Aminolevulinate (Mal) Clinicalmentioning

confidence: 99%

The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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“…Maździarz et al ( 113 ) evaluated the efficacy of PDD using two concentrations of 5-ALA cream (3 and 15%) in the detection of vulvar lesions. Vulvar tissue of two groups was exposed to the irradiated light (405 nm) after being coated with 5-ALA cream for 4–6 h. According to their results, the sensitivity of both 3%-ALA group and 15%-ALA group were 100%, and the specificity of two groups were 92 and 91.4%, respectively.…”

Section: Clinical Applicationsmentioning

confidence: 99%

5-aminolevulinic acid induced photodynamic reactions in diagnosis and therapy for female lower genital tract diseases

Chen,

Guo,

Chen

et al. 2024

Front. Med.

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Since the patients suffering from female lower genital tract diseases are getting younger and younger and the human papilloma virus (HPV) infection is becoming more widespread, the novel non-invasive precise modalities of diagnosis and therapy are required to remain structures of the organ and tissue, and fertility as well, by which the less damage to normal tissue and fewer adverse effects are able to be achieved. In all nucleated mammalian cells, 5-Aminolevulinic acid (5-ALA) is an amino acid that occurs spontaneously, which further synthesizes in the heme biosynthetic pathway into protoporphyrin IX (PpIX) as a porphyrin precursor and photosensitizing agent. Exogenous 5-ALA avoids the rate-limiting step in the process, causing PpIX buildup in tumor tissues. This tumor-selective PpIX distribution after 5-ALA application has been used successfully for tumor photodynamic diagnosis (PDD) and photodynamic therapy (PDT). Several ALA-based drugs have been used for ALA-PDD and ALA-PDT in treating many (pre)cancerous diseases, including the female lower genital tract diseases, yet the ALA-induced fluorescent theranostics is needed to be explored further. In this paper, we are going to review the studies of the mechanisms and applications mainly on ALA-mediated photodynamic reactions and its effectiveness in treating female lower genital tract diseases.

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“…The obtained results showed a high correlation between the accuracy of the PDD method in the study of vulvar lesions and the accuracy of histological examination, especially in the case of precancerous lesions and vulvar cancer. The observed fluorescence obtained during the PDD study provided important information on the spread and diversity of vulvar lesions (58). In 2014, the team from Bia≥ystok also conducted research on PDT in the treatment of oral leukoplakia.…”

Section: Photodynamic Diagnostic and Therapy In Europe North Americamentioning

confidence: 99%

Fluorescence Diagnostics and Photodynamic Therapy In Cancer

Ożóg¹,

Domka²,

Bartusik‐Aebisher³

et al. 2020

Acta Poloniae Pharmaceutica - Drug Research

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Recently, fluorescence diagnostics and photodynamic therapy (PDT) is increasingly gaining in popularity for clinical use. The purpose of this review was to describe the results of using laser and molecular techniques to develop targeted cancer therapy for improved drug delivery to cancer cells with regards to tissue visualization, single-cell localization, monitoring of treatment, and drug efficacy.

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Comparison of efficiency of photodynamic diagnostics with topical use of the 3% and 15% aminolevulinic acid in the detection of vulvar lesions

Cited by 6 publications

References 7 publications

The use of photodynamic therapy in medical practice

The use of photodynamic therapy in medical practice

5-aminolevulinic acid induced photodynamic reactions in diagnosis and therapy for female lower genital tract diseases

Fluorescence Diagnostics and Photodynamic Therapy In Cancer

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