Comparison of Electrical and Ultrasound Neurostimulation in Rat Motor Cortex

Gulick, Daniel; Li, Tao; Kleim, Jeffrey A.; Towe, Bruce C.

doi:10.1016/j.ultrasmedbio.2017.08.937

Cited by 27 publications

(29 citation statements)

References 30 publications

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“…Gas bubble formation and explosion was proposed to be a possible mechanism [46] while other studies suggested gas bubbles may not be a major cause [47]. A recent study by Gulick et al [48] demonstrated that the effect of ultrasound stimulation on the rat motor cortex was completely different from that by electrical stimulation, and they suggested this could be a microbubble-related effect.…”

Section: Discussionmentioning

confidence: 99%

Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson's Disease Model Mice

et al. 2019

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In this study, we have, for the first time, demonstrated the beneficial effects of transcranial magneto-acoustic stimulation (TMAS), a technique based on focused ultrasound stimulation within static magnetic field, on the learning and memory abilities and neuroplasticity of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD). Our results showed that chronic TMAS treatment (2 weeks) improved the outcome of Morris water maze, long-term potentiation (LTP), and dendritic spine densities in the dentate gyrus (DG) region of the hippocampus of PD model mice. To further investigate into the underlying mechanisms of these beneficial effects by TMAS, we quantified the proteins in the hippocampus that regulated neuroplasticity. Results showed that the level of postsynaptic density protein 95 was elevated in the brain of TMAS-treated PD model mice while the level of synaptophysin (SYP) did not show any change. We further quantified proteins that mediated neuroplasticity mechanisms, such as brain-derived neurotrophic factor (BDNF) and other important proteins that mediated neuroplasticity. Results showed that TMAS treatment elevated the levels of BDNF, cAMP response element-binding protein (CREB), and protein kinase B (p-Akt) in the PD model mouse hippocampus, but not in the non-PD mouse hippocampus. These results suggest that the beneficial effects on the neuroplasticity of PD model mice treated with TMAS could possibly be conducted through postsynaptic regulations and mediated by BDNF.

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Section: Discussionmentioning

confidence: 99%

Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson's Disease Model Mice

et al. 2019

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“…Similar to prior reports of M1 TUS in humans (Gibson et al, 2018;Legon et al, 2018b), we were unable to evoke motor potentials or EMG activities by application of TUS alone to the motor cortex. Interestingly, studies in small rodents consistently show EMG activity and frank motor contractions of hindlimbs (Gulick et al, 2017), whiskers (Mehić et al, 2014), and tail (Yoo et al, 2013) contralateral to the sonicated motor cortex, as well as inducing eye movements and pupillary dilatation (Kamimura et al, 2016). Although the majority of these studies were done under complete or partial anesthesia, recent studies with awake, freely moving rats have also found that TUS alone can also trigger truncal and limb movements (Lee et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior

Fomenko

Chen

Nankoo

et al. 2020

eLife

100

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Low-intensity transcranial ultrasound (TUS) can non-invasively modulate human neural activity. We investigated how different fundamental sonication parameters influence the effects of TUS on the motor cortex (M1) of 16 healthy subjects by probing cortico-cortical excitability and behaviour. A low-intensity 500 kHz TUS transducer was coupled to a transcranial magnetic stimulation (TMS) coil. TMS was delivered 10 ms before the end of TUS to the left M1 hotspot of the first dorsal interosseous muscle. Varying acoustic parameters (pulse repetition frequency, duty cycle and sonication duration) on motor-evoked potential amplitude were examined. Paired-pulse measures of cortical inhibition and facilitation, and performance on a visuomotor task was also assessed. TUS safely suppressed TMS-elicited motor cortical activity, with longer sonication durations and shorter duty cycles when delivered in a blocked paradigm. TUS increased GABAA-mediated short-interval intracortical inhibition and decreased reaction time on visuomotor task but not when controlled with TUS at near-somatosensory threshold intensity.

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“…Here we present three potential interpretations for how the brain responds to ultrasound energy deposition (Figure 1). Given the extensive electrophysiological [20,21,30,32], neurovascular [24,29,34,41], motor [14,16–18,22,23] and cognitive [32,35,36] evidences in support of tFUS-induced direct neural effects, we further examine whether the auditory pathway in the small brain volumes of rodent or mouse models dictates or impacts the observed activation patterns.…”

Section: Introductionmentioning

confidence: 99%

On the neuromodulatory pathways of the in vivo brain by means of transcranial focused ultrasound

Niu

2018

Current Opinion in Biomedical Engineering

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For last decade, low-intensity transcranial focused ultrasound (tFUS) has been rapidly developed for a myriad of successful applications in neuromodulation. tFUS possesses high spatial resolution, focality and depth penetration as a noninvasive neuromodulation tool. Despite the promise, confounding activation can be observed in rodents when stimulation parameters are not selected carefully. Here we summarize the existing classes of observations for ultrasound neuromodulation: ultrasound directly activates a localized area, or ultrasound indirectly activates auditory pathways, which further propagates to other cortical networks. We also present control in vivo animal studies, which suggest that underlying tFUS brain modulation is characterized by localized activation independent of auditory networks activations.

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Comparison of Electrical and Ultrasound Neurostimulation in Rat Motor Cortex

Cited by 27 publications

References 30 publications

Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson's Disease Model Mice

Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson's Disease Model Mice

Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior

On the neuromodulatory pathways of the in vivo brain by means of transcranial focused ultrasound

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