Comparison of electron beam irradiation with gamma processing for medical packaging materials

Woo, Lecon; Sandford, Craig

doi:10.1016/s0969-806x(01)00664-8

Cited by 80 publications

(41 citation statements)

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“…As a matter of fact at the same applied dose, β-ray treatment may cause an overheating of the material, while γ-ray treatment could prolong the peroxidative radiolitic mechanisms owing to the longer exposure time. 1 Moreover, the electron beam irradiation process is faster, easier from an operative point of view, less expensive, and it does not incur environmental risks of nuclear irradiation. 1 Hard capsules used in pharmaceutics, health food, and herbal preparations could be radiated to sanitize the products in the final step of manufacturing process.…”

Section: Introductionmentioning

confidence: 99%

“…1 Moreover, the electron beam irradiation process is faster, easier from an operative point of view, less expensive, and it does not incur environmental risks of nuclear irradiation. 1 Hard capsules used in pharmaceutics, health food, and herbal preparations could be radiated to sanitize the products in the final step of manufacturing process. The final sterilization could also be an alternative to aseptic production of hard capsules used as pulmonary dosage forms.…”

Section: Introductionmentioning

confidence: 99%

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Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules

et al. 2005

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The effects of electron beam or γ-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated by capillary viscometry and atomic force microscopy (AFM). The capsules were irradiated in the air at 5, 15, and 25 kGy. The deforming work of nonirradiated HPMC capsules (0.06 ± 0.01 J) was lower than that of gelatin capsules (0.10 ± 0.01 J). The dissolution time of the HPMC capsules (414 ± 33 seconds) was slightly higher than that determined for gelatin hard capsules (288 ± 19 seconds). The hardness and dissolution time of gelatin and HPMC capsules were not significantly influenced by the irradiation type and the applied irradiation dose. As the viscometry analyses are concerned, irradiation caused a reduction of the intrinsic viscosity and water and dimethyl sulfoxide solvent power in both the cases. AFM analysis showed that the radiation treatment did not appreciably affect the surface roughness of the samples nor induce structural changes on capsule surface. However, measurements of force-distance curves pointed out a qualitative parameter for the identification of the irradiated capsules. On the bases of these preliminary results, empty gelatin or HPMC hard capsules can be sanitized/ sterilized by ionizing radiation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules

et al. 2005

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“…On the other hand, the chemical lability of the active constituents and polymeric matrix materials generally limits the strategies employed for obtaining and acceptable sterile product to either an aseptic process, or terminal sterilization by γ-irradiation of the final product 22 . However, γ-radiation as a form of electromagnetic radiation, characterized by high penetration at a very low dose rate, can modify the performance of the drug delivery system, prolonging the peroxidative radiolytic mechanism due to the exposure time 23 . For instance, degradation products of the polymers can modify the aqueous environmental conditions thereby resulting in alterations of the pH inside the dosage forms 24 .…”

Section: Resultsmentioning

confidence: 99%

Effect of Gamma-Irradiation on Biodegradable Microspheres Loaded With Rasagiline Mesylate

Fernández

Barcia

Negro

2016

J. Chil. Chem. Soc.

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In the present study, the influence of gamma-irradiation was evaluated on the physicochemical characteristics and in vitro release of rasagiline mesylate (RM), a selective MAO-B inhibitor used in Parkinson's disease, from poly(D,L-lactide-co-glycolide) (PLGA) microspheres. Microspheres were prepared using PLGA 50:50 by the solvent evaporation technique (O/W emulsion). Microspheres were sterilized by gamma-irradiation and their influence was assessed by scanning electron microscopy (SEM), laser light diffraction, differential scanning calorimetry (DSC), X-ray diffraction (XRD), gel permeation chromatography (GPC), encapsulation efficiency (EE) and in vitro drug release. Gamma-irradiation of RM-loaded microspheres did not affect EE, DSC and XRD patterns. After gamma-irradiation, changes on the surface were observed by SEM, but no significant difference in mean particle size was observed. GPC measurements showed a decrease in molecular weight of the polymer after five days of in vitro release. The similarity factor value between irradiated and non-irradiates microspheres was <50, indicating the non-similarity of the release profiles. The sterilization technique had an effect on the integrity of polymeric system, significantly affecting in vitro release of RM from PLGA microspheres. Therefore, from our results we conclude that gamma-irradiation is not a suitable sterilization procedure for this formulation.

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“…As a semicrystalline material, it shows a very broad melting transition because of wide dispersion of the crystallite sizes and the variety of imperfections in the ordered phase [6,7]. The DSC method is also used in isothermal mode for measuring oxidative induction time (OIT) related to the copolymer stability [8][9][10]. The goal of our work was to monitor the influence of dose rate and total dose absorbed at two various temperatures on some parameters characterizing the extent of degradation.…”

Section: Introductionmentioning

confidence: 99%

Inverse effect in simultaneous thermal and radiation aging of EVA insulation

Przybytniak¹,

Boguski²,

Plaček³

et al. 2015

Express Polym. Lett.

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Abstract. Poly(ethylene-co-vinyl acetate) (EVA) insulation of the cable applied in nuclear power plants was accelerated aged by gamma-rays at two various temperatures, namely 55 and 85°C. Radiation degradation in the dose range of 0-1500 kGy was monitored using a Differential Scanning Calorimetry method by measuring oxidative induction temperature (OITp), gel fraction, mechanical and electrical tests. It was confirmed that a dose rate effect in the range of 420-1500 Gy/h was negligible whereas progress of degradation with increasing dose was strongly temperature dependent. For the insulation accelerated aged at 85°C the OITp and permittivity measurements confirmed lower degradation than for the specimens radiation treated at 55°C at the same dose rates. It was postulated that an inverse thermal effect resulted from radiation induced cross-linking facilitated by melting of EVA crystallites at 85°C.

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Comparison of electron beam irradiation with gamma processing for medical packaging materials

Cited by 80 publications

References 1 publication

Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules

Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules

Effect of Gamma-Irradiation on Biodegradable Microspheres Loaded With Rasagiline Mesylate

Inverse effect in simultaneous thermal and radiation aging of EVA insulation

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