“…Previous studies have reported that the most common acute adverse events during and after PDT include pain, erythema, edema, exudation, and crusting [ 30 – 32 ]. However, the main adverse reactions of cryotherapy are pain, blisters, blood blisters, infection, exudation, and edema [ 33 ]. In the present study, the mean NRS-10 pain score was higher in the PDT group than in the cryotherapy group, indicating that PDT caused more severe pain during treatment.…”