Comparison of Epidemiology and Outcomes in Neuro-Oncology Between the East and the West: Challenges and Opportunities

Gupta, Tejpal; Achari, R.; Chatterjee, Abhishek; Chen, Z.-P.; Mehta, Minesh P.; Bouffet, Éric; Jalali, Rakesh

doi:10.1016/j.clon.2019.05.018

Cited by 26 publications

(26 citation statements)

References 30 publications

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“…Central nervous system (CNS) tumours are much less prevalent, accounting for only 1-2% of the total cancer incidence. However, they represent a major source of mortality and morbidity [ 1 – 3 ]. In the United States, CNS cancers represent 1.4% of newly diagnosed cancers and 2.7% of cancer mortality [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…There is significant heterogeneity in the epidemiology, incidence, mortality, and histological spectrum of CNS tumours across different regions of the world [ 3 , 12 ]. The probable reason for such differences in epidemiologic patterns is yet unclear, but differences in environment, genetics, culture, age, and access to health resources could be considered [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Descriptive Epidemiology of Brain and Central Nervous System Tumours: Results from Iran National Cancer Registry, 2010-2014

Salimi

Zali

Seddighi

et al. 2020

Journal of Cancer Epidemiology

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Background. Central nervous system (CNS) tumours account for only 1-2% of cancer incidence but are a major reason for mortality and morbidity due to malignancies. Recent studies show an increase in the rate of CNS tumours worldwide, especially in developing countries. Moreover, there is significant heterogeneity in epidemiological patterns worldwide. This study is aimed at representing nationwide epidemiology of CNS tumours in Iran. Methods. Iran National Cancer Registry 2010-2014 data were reviewed for CNS tumours. The epidemiological rates were calculated for both genders and all age groups using the 2011 census information. Results. Out of 17345 cases, 58.5% were men and 41.5% were women. The mean age was 45.55 years ranging from less than 1 month to 100 years old. Average total age-standardized incidence rate (ASR) was 5.19 for primary tumours. The annual percent change (APC) was 14.23% during the study period. The most frequent site and histology recorded were brain, NOS and diffuse astrocytic, respectively. Geographical distribution showed about five-fold difference in ASRs between different provinces. Conclusion. The overall ASR calculated was higher than the global rate in 2012 but lower than that of most developed countries, showing an increasing trend which may be due to either advances in diagnosing or risk factor augmentation. The mean age and incident rates were higher than those of previous reports in Iran.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Descriptive Epidemiology of Brain and Central Nervous System Tumours: Results from Iran National Cancer Registry, 2010-2014

Salimi

Zali

Seddighi

et al. 2020

Journal of Cancer Epidemiology

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“…In fact, only one systematic review on the worldwide incidence of brain tumors was published in 1998, subsequently another study was published in 2015 concluding that the worldwide incidence of all brain tumors is 10.82 per 100,000 person-years [ 8 ]. Although the age-adjusted annual incidence of CNS tumors is reportedly low, it is widely variable with nearly a fivefold difference between highest rates reported mainly in developed countries in the West (North America and Western Europe) and the lowest rates reported in developing countries in southeast Asia [ 10 ].…”

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confidence: 99%

“…This paucity and discrepancy of published data might be due to small sample sizes in studies, possibly because brain tumors are relatively less frequent than other tumors, known to account for 1–2% of the overall cancer burden [ 10 ], to different geographic repartition between regions and countries or to differences between the studies regarding the patients, the tumor types and the methods of classification of these tumors. We can add the differences in studies quality, knowing particularly that studies led in eastern countries are not based on data from national-based cancer registries and therefore result in biased estimates [ 10 ]. On the other hand, research in brain tumors is expanding worldwide after developing technologies in brain imaging, oncogenetics and the molecular biology of brain tumors [ 9 ].…”

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confidence: 99%

Epidemiologic and histologic characteristics of CNS lesions: a 20-year experience of a tertiary center in Lebanon

et al. 2020

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Aim: Report the epidemiologic and histologic characteristics of CNS lesions in the Lebanese population. Methods: We conducted a retrospective study evaluating 2025 CNS lesions diagnosed between 1998 and 2017 in the pathology laboratory of a Lebanese tertiary center. Results: 52.2% of patients were men with a median age of 50 years. The most frequent symptoms were epilepsy (22.5%), headache (20.6%) and motor impairment (19.9%). 90.7% of tumors were primary. Lung (35.6%) and breast (16.5%) were the most frequent primaries of metastases. 46.2% of primary CNS tumors were glial, predominantly astrocytic (56.4%), and (42.5%) were nonglial, predominantly meningeal tumors (58%). Conclusion: Compared with Western literature, the Lebanese population is characterized by a younger age of onset of brain tumors, a lower rate of meningiomas and a higher rate of gliomas.

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“…The global variability of CNS tumors have been attributed to differences in environmental factors, genetic susceptibility, cultural practices, and resources for accurate diagnosis (6). Multidisciplinary approach including neurologists, neurosurgeons, radiation oncologists, and neuropathologists is the usual practice in treating patients with CNS tumors; however most data on regional practice mostly come from Western countries (7).…”

Section: Introductionmentioning

confidence: 99%

Primary Brain Tumor Research Productivity in Southeast Asia and Its Association With Socioeconomic Determinants and Burden of Disease

2020

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BackgroundThere is an unmet need to assess research productivity from southeast Asia (SEA) regarding primary central nervous system (CNS) tumors. The country’s economy, landscape of neurology practice, and disease burden are hypothesized to correlate with scientific output. This study aimed to objectively measure the impact of published studies on primary brain tumors in SEA and to assess for correlation with socioeconomic determinants and burden of disease.MethodsWe systematically searched electronic databases for relevant articles from SEA on primary CNS tumor until July 31, 2020. Bibliometric indices were reported and subjected to correlational analysis with population size, gross domestic product (GDP) per capita, percentage (%) GDP for research and development (R&D), total number of neurologists, disease incidence, deaths, and disability-adjusted life years.ResultsA total of 549 articles were included, consisting primarily of case reports (n=187, 34.06%) and discussed gliomas (n=195, 35.52%). Singapore published the most number of the articles (n=246, 44.8%). Statistical analysis showed a positive correlation between %GDP for R&D and total publication. Additionally, negative relationships were noted between burden of disease and total neurologist with most bibliometric indices. However, GDP per capita was not correlated with measures for research productivity.ConclusionThe low impact of scientific output on primary CNS tumors in SEA does not address the growing epidemiology and burden of this disease. An increase in the GDP growth and financial and manpower investment to R&D may significantly improve research productivity in SEA.

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Comparison of Epidemiology and Outcomes in Neuro-Oncology Between the East and the West: Challenges and Opportunities

Cited by 26 publications

References 30 publications

Descriptive Epidemiology of Brain and Central Nervous System Tumours: Results from Iran National Cancer Registry, 2010-2014

Descriptive Epidemiology of Brain and Central Nervous System Tumours: Results from Iran National Cancer Registry, 2010-2014

Epidemiologic and histologic characteristics of CNS lesions: a 20-year experience of a tertiary center in Lebanon

Primary Brain Tumor Research Productivity in Southeast Asia and Its Association With Socioeconomic Determinants and Burden of Disease

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