Comparison of erythromycin ethylsuccinate and co-trimoxazole for treatment of pertussis

Hoppe, J. E.; Halm, U.; Hagedorn, H.; Kraminer-Hagedorn, Anna

doi:10.1007/bf01639525

Cited by 43 publications

(4 citation statements)

References 26 publications

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“…Co-trimoxazole is a less active agent against B. pertussis strains. However, it can be used in children who cannot tolerate erythromycin or the ones infected by resistant isolates of B. pertussis (29). …”

Section: Discussionmentioning

confidence: 99%

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

Shahcheraghi

Lotfi

Nikbin

et al. 2014

Jundishapur J Microbiol

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Background:Whooping cough was considered as one of the major causes of childhood morbidity and mortality worldwide. Resistant isolates of Bordetella pertussis to macrolides in some countries have been recently reported.Objectives:Recent reports on macrolide-resistant B. pertussis isolates and lack of evidence for such resistance in clinical isolates of the Iranian patients led the authors of the current study to study antibiotic susceptibility of the collected isolates in the country. Susceptibility of the B. pertussis isolates to three antibiotics was studied. Relatedness of the strains recovered in this research was also examined.Materials and Methods:The antibacterial activities of erythromycin, azithromycin, and clarithromycin antibiotics against the recovered isolates of 779 nasopharyngeal swabs were examined using MIC (Minimum Inhibitory Concentration) method. Relationship of the strains was characterized by Pulsed-field Gel Electrophoresis (PFGE).Results:Among the specimens, 11 cases (1.4%) were culture-positive. Among these isolates, only two isolates had high MIC values for erythromycin and clarithromycin. Pulsed-field gel electrophoresis analysis of the isolates revealed 6 PFGE profiles (A-F) among which three and two isolates had the same patterns in profiles A and B, respectively.Conclusions:Azithromycin can be a good drug of choice to treat patients infected by B. pertussis in Iran. Clonal relationship of the isolates showed that the same B. pertussis strains were isolated from different patients in Iran.

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Section: Discussionmentioning

confidence: 99%

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

Shahcheraghi

Lotfi

Nikbin

et al. 2014

Jundishapur J Microbiol

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“…Since erythromycin is accompanied by uncomfortable to distressing side effects that result in poor adherence to the treatment regimen two other macrolide agents (azithromycin and clarithromycin) are used for the treatment and prophylaxis of pertussis [23]. An alternate regimen is trimethoprimsulfamethoxazole [24].…”

Section: Discussionmentioning

confidence: 99%

Neurologic alterations in an HIV adult patient with pertussis: a case report

Arango-Granados

Trompa

2020

BMC Infect Dis

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Background Pertussis is a highly contagious disease of public health interest caused by the bacterium Bordetella pertussis. Although its incidence has decreased substantially after the introduction of a vaccination, the burden of the disease remains high. Although the paroxysmal phase is highly disabling, complications are uncommon and more prevalent in children than in adults. The most frequent neurological complication is encephalopathy, but seizures, paresis, paraplegia, ataxias, aphasias, and decerebration postures have also been described. The complication of decerebration postures has not been previously reported in adults. Case presentation We present a video case of an adult HIV patient with severe coughing paroxysms, post-tussive emesis and syncope, whose workup confirmed the diagnosis of a B. pertussis respiratory infection. During hospitalization, he had fluctuant encephalopathy and post-tussive decerebration postures following paroxysms. He was treated with antibiotic therapy and finally sent home without residual neurological deficits. Conclusion This case illustrates the biological plausibility of neurologic complications of pertussis in adults, which, albeit rare, can cause important morbidities. Future research should explore whether there are differences in the clinical presentation, risk factors and pathophysiology of the disease among adults or interventions aimed at preventing or treating pertussis encephalopathy.

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“…• SMX/TMP can be used to treat pertussis when macrolides cannot be used. However, SMX/TMP and erythromycin have been reported to have the same eradication effect, 20 there have been no studies to evaluate the efficacy of SMX/TMP when administered as postexposure prophylaxis.…”

Section: Cq 9: Are Antibiotics Recommended For Prevention Of Pertussi...mentioning

confidence: 99%

Guidelines for the Management of Respiratory Infectious Diseases in Children in Japan 2022

Ishiwada,

Shinjoh,

Kusama

et al. 2023

Pediatric Infectious Disease Journal

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The members of the Japanese Society for Pediatric Infectious Diseases and the Japanese Society of Pediatric Pulmonology have developed Guidelines for the Management of Respiratory Infectious Diseases in Children with the objective of facilitating appropriate diagnosis, treatment and prevention of respiratory infections in children. The first edition was published in 2004 and the fifth edition was published in 2022. The Guideline 2022 consists of 2 parts, clinical questions and commentary, and includes general respiratory infections and specific infections in children with underlying diseases and severe infections. This executive summary outlines the clinical questions in the Guidelines 2022, with reference to the Japanese Medical Information Distribution Service Manual. All recommendations are supported by a systematic search for relevant evidence and are followed by the strength of the recommendation and the quality of the evidence statements.

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Comparison of erythromycin ethylsuccinate and co-trimoxazole for treatment of pertussis

Cited by 43 publications

References 26 publications

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

Neurologic alterations in an HIV adult patient with pertussis: a case report

Guidelines for the Management of Respiratory Infectious Diseases in Children in Japan 2022

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