Comparison of ethanol locomotor sensitization in adolescent and adult DBA/2J mice

Stevenson, Rebekah A.; Besheer, Joyce; Hodge, Clyde W.

doi:10.1007/s00213-007-1038-y

Cited by 58 publications

(73 citation statements)

References 52 publications

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“…Regarding the adverse and unpleasant effects of alcohol, a lower sensitivity to the sedative (Little et al 1996;Quoilin et al 2010;Silveri and Spear 1998), ataxic (White et al 2002), and hypothermic (Silveri and Spear 2000) effects of ethanol have been reported in adolescent relative to adult rats and mice. In contrast, adolescent rodents have been shown to be more sensitive than adults to the locomotor stimulant effects of ethanol (Quoilin et al 2010;Stevenson et al 2008) and to ethanol-induced social facilitation (Varlinskaya and Spear 2002).…”

Section: Introductionmentioning

confidence: 91%

“…Previous studies showed that adolescent Swiss mice, in contrast to adults, did not develop locomotor sensitization to ethanol or even show a behavioral tolerance to the locomotor stimulant effects of ethanol after repeated ethanol administrations (CarraraNascimento et al 2011;Faria et al 2008). In another study on DBA/2J mice, Stevenson et al (2008) reported that adolescent mice were less sensitive than adult mice to ethanol-induced sensitization. However, these studies were limited to the comparison of two age groups (adults and adolescents) and low to moderate doses of ethanol (between 1.0 and 2.5 g/kg).…”

Section: Introductionmentioning

confidence: 92%

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Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

et al. 2011

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 92%

Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

et al. 2011

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“…Studies report hyposensitivity (Faria et al, 2008;Stevenson, Besheer, & Hodge, 2008) or hypersensitivity (Hefner & Holmes, 2007) to ethanol's stimulating or sensitizing effects during adolescence, compared to adulthood. We showed that CUS-ETOH adolescents also displayed lower cross-sensitization, compared to adults.…”

Section: Discussionmentioning

confidence: 99%

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Santos-Rocha

Rae

Teixeira

et al. 2018

Alcohol

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a b s t r a c tThe peculiar neurochemical profile of the adolescent brain renders it differently susceptible to several stimuli, including stress and/or drug exposure. Among several stress mediators, nitric oxide (NO) has a role in stress responses. We have demonstrated that adolescent mice are less sensitive to ethanolinduced sensitization than adult mice. The present study investigated whether chronic unpredictable stress (CUS) induces behavioral sensitization to ethanol in adolescent and adult Swiss mice, and investigated the influence of Ca 2þ -dependent nitric oxide synthase (NOS) activity in the phenomenon.Adolescent and adult mice were exposed to repeated 1.8 g/kg ethanol or CUS and challenged with saline or ethanol. A neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7NI), was administered along with ethanol and CUS to test its effects on behavioral sensitization. Both adolescent and adult mice displayed cross-sensitization between CUS and ethanol in adult mice, with adolescents showing a lower degree of sensitization than adults. nNOS inhibition by 7NI reduced both ethanol sensitization and crosssensitization. All age differences in the Ca 2þ -dependent NOS activity in the hippocampus and prefrontal cortex were in the direction of greater activity in adults than in adolescents. Adolescents showed lower sensitivity to cross-sensitization between CUS and ethanol, and the nitric oxide (NO) system seems to have a pivotal role in ethanol-induced behavioral sensitization and cross-sensitization in both adolescent and adult mice.

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“…Age can also influence the mechanism of sensitization. This reflects different mechanisms of neurobehavioral adaptations in different groups of ages Stevenson, Besheer, & Hodge, 2008). The activation of accumbal D2 receptors is essential for the expression of signs of behavioral sensitization (Abrahao, Quadros, Andrade, & SouzaFormigoni, 2012).…”

Section: Discussionmentioning

confidence: 99%

Morphine Addiction is Tolerated Better in Socialized Male Rats

Famitafreshi¹,

Karimian²

2017

Sleep Hypn

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Drug abuse in some addicts progresses to compulsive drug seeking and taking behaviors. High-risk addictive behaviors tend to make interactions between an addict and the community more complex. Socialization is a necessary process that needs to be developed to accommodate to social life.The aim of this study was to evaluate the benefits of social interaction during addiction. Forty two (42) male Sprague-Dawley rats were randomly divided into four groups: social, isolated, socialized morphine-treated (SMT) and isolated morphine-treated (IMT). At the end of the study, neurogenesis, corticosterone, nitrite/nitrate, anhedonia with forced swim test and sucrose and salt craving were examined. Neurogenesis was reduced in IMT group compared to SMT group. SMT animals and control demonstrated better forced swim test performance compared to IMT animals. Furthermore, sucrose and salt (NaCl 3%) consumption was found to be higher in IMT animals compared to SMT animals. Corticosterone was higher in IMT rats compared to SMT rats. Nitrite/nitrate was higher in IMT rats compared to SMT rats. Socialization preserves brain functions necessary for life. Hence, socialized addicts can better tolerate addiction-induced adverse effects.

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Comparison of ethanol locomotor sensitization in adolescent and adult DBA/2J mice

Abstract: These results indicate that adolescent mice are less sensitive to ethanol sensitization, and this blunted behavioral response in adolescents might reflect differential ethanol-induced neurobehavioral adaptations.

Cited by 58 publications

References 52 publications

Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Morphine Addiction is Tolerated Better in Socialized Male Rats

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