Comparison of FDG-PET with MIBI-SPECT in the Detection of Breast Cancer and Axillary Lymph Node Metastasis

Yutani, Kenji; Shiba, Eiichi; Kusuoka, Hideo; Tatsumi, Mitsuaki; Uehara, Toshiisa; Taguchi, Tetsuya; Takai, S

doi:10.1097/00004728-200003000-00017

Cited by 81 publications

(43 citation statements)

References 18 publications

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“…Comparable results were found in a study using GCPET to detect primary lesions in 26 women with a sensitivity of 84.6% (24). However, in the same study, GCPET detected axillary lymph node metastases with a sensitivity of 40% and specificity of 100% (24).…”

Section: Introductionsupporting

confidence: 58%

“…Previously, we successfully reported the use of GCPET in the detection of primary breast tumours with a superior sensitivity, compared with mammography and ultrosonography (23). Comparable results were found in a study using GCPET to detect primary lesions in 26 women with a sensitivity of 84.6% (24). However, in the same study, GCPET detected axillary lymph node metastases with a sensitivity of 40% and specificity of 100% (24).…”

Section: Introductionmentioning

confidence: 85%

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18F-FDG dual-headed gamma camera PET in detection of axillary nodal disease in patients with large or locally advanced breast cancer: Possible alternative staging of axilla

Syed

Marshall²,

Griffiths³

et al. 2007

Oncol Rep

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Abstract. Positron emission tomography (PET) has been used in staging the axilla. Gamma Camera PET (GCPET) is a cost effective alternative, but poorly studied. The aim of this study was to assess GCPET in demonstrating metastatic deposits in axillary nodes in patients with a high likelihood of nodal disease. Twenty-seven women with large (T2, T3 or T4) or advanced breast cancer (N1, N2 or M1) were recruited. All patients underwent axillary lymph node removal or biopsy (fine needle aspiration cytology (FNAC) or core cut) and whole body GCPET imaging. Images were reported anonymously and compared with the histological findings. Twenty-one patients proceeded to surgery and 10 had tumour-involved axillary nodes; GCPET was positive in 8 of these. The remaining 6 patients underwent core cut or FNAC of the axillary nodes, 2 of which contained a tumour. GCPET was positive in both cases. Thus, the diagnostic values were: sensitivity 83%, specificity 100%, positive predictive value 100%, negative predictive value 88% and accuracy 93%. In conclusion, GCPET is a reliable method and can be performed in a district general hospital and detecting disease in axillary nodes in certain patients, possibly obviating the need for surgery.

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Section: Introductionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 85%

18F-FDG dual-headed gamma camera PET in detection of axillary nodal disease in patients with large or locally advanced breast cancer: Possible alternative staging of axilla

Syed

Marshall²,

Griffiths³

et al. 2007

Oncol Rep

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“…Nine studies recruited patients both prospectively and consecutively. 85,90,93,94,96,97,106,107 The number of analysed patients (relevant to this review) ranged from 24 to 308. Fourteen studies presented data such that the patients analysed in this review were entirely early stage (stage I, II or IIIA), newly diagnosed and non-DCIS, 44,75,76,80,[83][84][85][86][87][88][89]92,94,97 while the remaining 12 studies comprised up to 20% of patients who did not meet these criteria.…”

Section: Study Characteristicsmentioning

confidence: 99%

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation

Cooper

Meng²,

Harnan³

et al. 2011

Health Technol Assess

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An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research a...

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“…It is common clinical practice in patients with breast cancer to carry out ultrasound of the axilla together with fine needle aspiration cytology of any suspicious axillary nodes that are identified (or palpable) prior to patients undergoing SNB [10]. Similarly MRI [11,32], CT [33,34], mammography [7,11] and other non-PET radionuclides (MIBI) [25] have all been suggested as useful in the staging of the axilla. It would not be the aim to perform a complete review of all modalities at this stage, since an extensive number of studies have not been carried out in all modalities.…”

Section: Introductionmentioning

confidence: 99%

The use of FDG-PET in assessing axillary lymph node status in breast cancer: a systematic review and meta-analysis of the literature

Peare

Staff

Heys

2010

Breast Cancer Res Treat

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International audienceAxillary lymph node status is the most powerful prognostic indicator in patients with breast cancer. FDG-PET has been suggested as a non-invasive method of staging the axilla. The aim of this study was to review and aggregate all studies that measured the performance of FDG-PET in patients with breast cancer, using surgically obtained axillary histology as a reference, in a meta-analysis. A systematic review of the literature was performed and data extracted from all eligible studies. These were then analysed using meta-analysis software and summary receiver operating characteristic (SROC) curves were plotted for the aggregate data. The data was then tested to determine which parameters impacted on the sensitivity and specificity of the studies. Sensitivities ranging from 20 to 100% and specificities ranging from 65 to 100% have been reported. An aggregated ROC analysis found an area under the curve of 0.95 (95% CI 0.91–0.97) and a * value of 0.89 (95% CI 0.85–0.92) in a total of 25 studies involving 2,460 patients. The AUC and * values indicated little difference between the compared study characteristics. The performance of the technique currently remains below, which is required to replace assessment of axillary node status by surgical biopsy and histological assessment. However, sensitivity and specificity are high and FDG-PET may have a role to play under particular circumstances. Moreover, the additional benefit of an assessment of distal metastatic spread provided by FDG-PET requires further investigation

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Comparison of FDG-PET with MIBI-SPECT in the Detection of Breast Cancer and Axillary Lymph Node Metastasis

Abstract: These results indicate that MIBI-SPECT is comparable with FDG-PET in detecting breast cancer. Neither FDG-PET nor MIBI-SPECT is sufficiently sensitive to rule out axillary lymph node metastasis.

Cited by 81 publications

References 18 publications

18F-FDG dual-headed gamma camera PET in detection of axillary nodal disease in patients with large or locally advanced breast cancer: Possible alternative staging of axilla

18F-FDG dual-headed gamma camera PET in detection of axillary nodal disease in patients with large or locally advanced breast cancer: Possible alternative staging of axilla

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation

The use of FDG-PET in assessing axillary lymph node status in breast cancer: a systematic review and meta-analysis of the literature

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