Comparison of Fibrin Glue and Sutures for Attaching Conjunctival Autografts After Pterygium Excision

Uy, Harvey S.; Reyes, Juvenal; Flores, John D.G.; Lim-Bon-Siong, Ruben

doi:10.1016/j.ophtha.2004.08.028

Cited by 190 publications

(149 citation statements)

References 26 publications

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“…These findings were also consistent with the studies of CA using fibrin glue, in which a number of different symptom scales have been used. [4][5][6][7][8] Shortening the surgery time and improving post-operative comfort may have several advantages. First, the use of fibrin glue removes the need for the tedious suturing process, the learning curve can be shortened, and better results may be more consistently achieved despite differences in surgical expertise.…”

Section: Discussionmentioning

confidence: 99%

“…This effort to mask the patients was also performed in earlier studies. [5][6][7][8] When fibrin glue is used, the retraction of the host conjunctiva or graft may result in gap formation between the graft in the early post-operative period. It is suggested that rapid epithelisation of the amniotic membrane prevents post-operative inflammation and thereby reduces the recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8] In addition, the outcomes of AMT using fibrin glue for corneal ulceration, perforation, and ocular surface reconstruction have been reported in clinical and experimental studies. [9][10][11][12][13] However, the results of pterygium surgery with AMT using fibrin tissue sealants have been evaluated in limited number of studies.…”

Section: Introductionmentioning

confidence: 99%

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Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Küçükerdönmez

Karalezlı

Akova

et al. 2009

Eye

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Purpose To compare the results of amniotic membrane transplantation (AMT) using fibrin glue vs vicryl sutures in pterygium surgery. Methods We carried out a prospective, randomised clinical study of 70 eyes (70 patients) with primary pterygium. After the removal of pterygium, patients were randomised to undergo AMT using fibrin glue (Tisseel, 32 eyes) or 8-0 vicryl sutures (38 eyes). Clinical examination and digital photographing were performed at each visit and the patients were followed up for at least 12 months. Post-operative symptoms in the first month were evaluated according to a fivepoint scale. Final appearances were graded from 1 to 4 in which grade 4 represented true (corneal) recurrence and grade 3 indicated conjunctival recurrence. Results The average operation time in the fibrin glue and suture groups were 11.2 ± 2.4 min (mean ± SD) and 18.7 ± 2.2 min, respectively (P ¼ 0.018). Significantly fewer post-operative symptoms were observed in the fibrin glue group at post-operative days 1, 7, and 14 (Po0.05 for all). At the end of the follow-up, true recurrence (grade 4) was developed in three eyes (9.4%) in the fibrin glue group, and in four eyes (10.5%) in the suture group (P ¼ 0.33). The rates of conjunctival recurrence (grade 3) were 21.9% (seven eyes) and 23.7% (nine eyes) in the fibrin glue and suture groups, respectively (P ¼ 0.38). Conclusions Amniotic membrane grafts can be successfully attached without any major complication in patients undergoing pterygium surgery. In addition, it is effective in shortening the duration of surgery and preventing post-operative discomfort. Although there seems to be no difference in the recurrence rates and cosmetic outcomes between both groups, neither technique represents best results.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Küçükerdönmez

Karalezlı

Akova

et al. 2009

Eye

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“…A meta-analysis was performed by Pan et al on seven pooled randomized control studies [66][67][68][69][70][71][72] comparing fibrin glue and suture outcomes for limbal-conjunctival autografting following pterygium excision [73]. A total of 342 participants and 366 eyes were encompassed in the seven studies.…”

Section: Pterygium Surgerymentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…Various different studies have compared the safety and recurrence rates of pterygium associated with the use of absorbable and non-absorbable sutures and the use of sutures and fibrin glue when making conjunctival autografts (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) . All of these studies concluded that the use of fibrin glue in pterygium surgery involving conjunctival autografting significantly reduces surgery time and improves postoperative patient comfort and cosmesis.…”

Section: Introductionmentioning

confidence: 99%

Pterygium surgery by means of conjunctival autograft: long term follow-up

Huerva¹,

March²,

Martínez-Alonso³

et al. 2012

Arq. Bras. Oftalmol.

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Purpose: To demonstrate the long term of follow-up of the recurrence rate after conjunctival autograft for pterygium surgery. Methods: A total of 112 patients operated for pterygium with conjunctival autografts and with more than one year follow-up were registered. Patients were called for voluntary examinations of their respective ocular surface statuses. Completing the study was only possible in 44 cases. Seven had bilateral pterygium. (N=51 operated pterygium). Results:The mean follow-up time was 49.06 months. In 29.45% of the cases, attachment was performed using non-absorbable sutures (nylon 10/0), while fibrin glue was used in 70.55% of the cases. Six cases of recurrence (11.76%) were found. The recurrence rate between primary and recurrent pterygium, and between sutures and fibrin glue proved to be not statistically significant; p>0.05. There were no significant differences between women and men with respect to recurrence. The median of age in the recurrence group was 40 years old, in contrast to 55 in the non-recurrence group; p=0.01517. All of these recurrences were associated with patients of Hispanic origins (from Latin America); p=0.001506. Conclusions: After a long follow-up period after autograft pterygium surgery, there were no statistically significant differences in recurrence rates for the application of sutures as opposed to fibrin glue; similarly, there were no statistically significant differences between the use of autograft in primary and recurrent pterygium. The greatest risk factors for recurrence were young age and Hispanic ethnicity.Keywords: Pterigium/surgery; Transplantation, autologous; Conjunctiva/transplantation, Sutures; Fibrin tissue adhesive RESUMO Objetivo: Demonstrar a taxa de recorrência em cirurgia do pterígio com transplante autólogo de conjuntiva após um acompanhamento a longo prazo. Métodos: Cento e doze pacientes operados de pterígio e transplante autólogo de conjuntiva, com mais de um ano de acompanhamento foram registrados. Os pacientes foram chamados para um exame voluntário de estado da superfície ocular. O estudo completo só foi possível em 44 pacientes. Sete deles tinha tido pterígio bilateral. (N=51). Resultados: A média de acompanhamento a partir do momento da cirurgia até o exame foi de 49,06 meses. A sutura não-absorvível (nylon 10/0) foi usada em 29,45% dos casos, enquanto que a cola biológica de fibrina foi usada em 70,55%. A recidiva do pterígio foi detectada apenas em 6 casos (11,76%). As recidivas entre pacientes operados de pterígio primário e recorrente, e entre o uso de suturas ou cola de fibrina não foram significativos (p>0,05). Também não houve diferença significativa na recorrência com relação ao sexo. A idade média no grupo de recidiva foi de 40 anos e no grupo sem recidiva de 55 anos (p=0,01517). Todas essas recorrências ocorreram em pacientes de origem hispânica (América latina) (p=0,001506). Conclusões: A longo prazo da remoção cirúrgica de pterígio utilizando um transplante autólogo de conjuntiva, não há diferença estatisticamente sig...

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Comparison of Fibrin Glue and Sutures for Attaching Conjunctival Autografts After Pterygium Excision

Cited by 190 publications

References 26 publications

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Tissue adhesives in ocular surgery

Pterygium surgery by means of conjunctival autograft: long term follow-up

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