Comparison of First and Second Wave Cohorts of Multisystem Inflammatory Disease Syndrome IN Children

Harahsheh, Ashraf S.; Sharron, Matthew; Bost, James E.; Ansusinha, Emily; Wessel, David; DeBiasi, Roberta L.

doi:10.1097/inf.0000000000003388

Cited by 13 publications

(6 citation statements)

References 10 publications

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“…In our study, a significantly higher proportion of patients were referred as MIS-C during the second wave compared to the first. Contrary to the observation by Harahsheh AS, et al 9 , we report that the need for ICU admission, shock, clinical myocarditis, need for respiratory support and involvement of 5 or more organs was significantly lower in the second wave, compared to the first.…”

Section: Table I: Clinical Presentation Of Children Admitted With Mis...contrasting

confidence: 99%

“…In our study, there was no significant difference in the mean age, male-female ratio or duration of fever before admission between the two waves. Similar to our study, Harahsheh AS, et al 9 in their study also did not find any significant change in the incidence of MIS-C in various age groups in the two surges in children below 12 years of age, but they had reported a significant increase in incidence in those above 15 years of age. Our study did not include children above 12 years of age.…”

Section: Table I: Clinical Presentation Of Children Admitted With Mis...supporting

confidence: 90%

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A hospital based comparative study of the first and second waves of Covid-19 related multi-system inflammatory syndrome in children

Sasidharan¹,

Sugunan²,

Monica³

et al. 2022

Sri Lanka J Child Health

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Introduction: Studies have shown the differential impact of the second surge of acute Covid-19 infection, across age, clinical outcome and ethnicity. How these factors impact the clinical characteristics and outcome of multisystem inflammatory syndrome in children (MIS-C) is largely unknown. Objectives: This hospital based comparative study was undertaken to analyse the clinical characteristics and outcomes of patients admitted with MIS-C during the two waves of Covid-19 infection in a tertiary care teaching hospital in South India. Method: Patients admitted between September 2020 and October 2021 with MIS-C were included in this study. Patient demographics, laboratory values and treatment details were compared between the two surges of COVID 19 related MIS-C.Results: Sixty-five children were admitted with MIS-C in the first wave and 73 in the second wave. More children were referred with a diagnosis of MIS-C in the second wave (p=0.001). There was no significant difference in the mean age or malefemale ratio between the two waves. A significantly higher proportion of children in the second wave had cervical lymphadenitis (p=0.02). Need for intensive care unit (ICU) admission (p<0.001), shock (p<0.001), respiratory support (p<0.001) and multiorgan involvement (p<0.001) were significantly lower in the second wave.

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Section: Table I: Clinical Presentation Of Children Admitted With Mis...contrasting

confidence: 99%

Section: Table I: Clinical Presentation Of Children Admitted With Mis...supporting

confidence: 90%

A hospital based comparative study of the first and second waves of Covid-19 related multi-system inflammatory syndrome in children

Sasidharan¹,

Sugunan²,

Monica³

et al. 2022

Sri Lanka J Child Health

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“…We do not believe these differences are related to treatment regimens, as these were standardized early in the pandemic. In a recently published data showing increased severity of clinical symptoms in MISC patients affected with the Alpha variant of SARS-CoV-2 in comparison with the original variant, our study shows that MIS-C patients with the Delta variant had lower disease severity ( 21 ). With anticipated emerging SARS-CoV-2 variants of concerns on the horizon, future studies comparing the clinical and laboratory values between variants of concern are warranted.…”

Section: Discussionsupporting

confidence: 53%

Comparison of Laboratory and Hemodynamic Time Series Data Across Original, Alpha, and Delta Variants in Patients With Multisystem Inflammatory Syndrome in Children

Jain

Acosta

Annapragada

et al. 2022

Pediatric Critical Care Medicine

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OBJECTIVES: To compare the clinical, laboratory, and hemodynamic parameters during hospitalization for patients with multisystem inflammatory syndrome in children (MIS-C), across the Original/Alpha and the Delta variants of severe acute respiratory syndrome coronavirus 2 infection. DESIGN: Retrospective cohort study. SETTING: Single-center quaternary children’s hospital. PATIENTS: Children with MIS-C admitted from May 2020 to February 2021(Original and Alpha variant cohort) and August 2021 to November 2021 (Delta variant cohort). MEASUREMENTS AND MAIN RESULTS: Continuous vital sign measurements, laboratory results, medications data, and hospital outcomes from all subjects were evaluated. Of the 134 patients (102 with Original/Alpha and 32 with Delta), median age was 9 years, 75 (56%) were male, and 61 (46%) were Hispanics. The cohort with Original/Alpha variant had more males (61% vs 41%; p = 0.036) and more respiratory/musculoskeletal symptoms on presentation compared with the Delta variant ( p < 0.05). More patients in the Original/Alpha variant cohort received mechanical ventilation (16 vs 0; p = 0.009). Median hospital length of stay (LOS) was 7 days, and ICU LOS was 3 days for the entire cohort. ICU LOS was shorter in cohort with the Delta variant compared with the Original/Alpha variant (4 vs 2 d; p = 0.001). Only one patient had cardiac arrest, two needed extracorporeal membrane oxygenation, and two needed left ventricular assist device (Impella, Danvers, MA), all in the Original/Alpha variant cohort; no mortality occurred in the entire cohort. MIS-C cohort associated with the Delta variant had lower INR, prothrombin time, WBCs, sodium, phosphorus, and potassium median values ( p < 0.05) during hospitalization compared with the Original/Alpha variants. Hemodynamic assessment showed significant tachycardia in the Original/Alpha variants cohort compared with the Delta variant cohort ( p < 0.05). INTERVENTIONS: None. CONCLUSIONS: Patients with MIS-C associated with the Delta variants had lower severity during hospitalization compared with the Original/Alpha variant. Analysis of distinct trends in clinical and laboratory parameters with future variants of concerns will allow for potential modification of treatment protocol.

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“… 2 Thus, when a new illness, Multisystem Inflammatory Syndrome in Children (MIS-C) was identified during the 2019 novel coronavirus disease (COVID-19) pandemic and had clinical similarities to KD, experts around the globe hoped that it’s emergence would facilitate the identification of an underlying etiology for KD. 3 , 4 , 5 , 6 , 7 Similar to KD, MIS-C is characterized by systemic inflammation 2 and can also be commonly associated with cardiac complications. 8 , 9 The overlap in the case definition and clinical features between MIS-C and KD suggests there is a possibility of, at least partially overlapping immunopathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Harahsheh

Shah

Dallaire

et al. 2024

Canadian Journal of Cardiology

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Comparison of First and Second Wave Cohorts of Multisystem Inflammatory Disease Syndrome IN Children

Cited by 13 publications

References 10 publications

A hospital based comparative study of the first and second waves of Covid-19 related multi-system inflammatory syndrome in children

A hospital based comparative study of the first and second waves of Covid-19 related multi-system inflammatory syndrome in children

Comparison of Laboratory and Hemodynamic Time Series Data Across Original, Alpha, and Delta Variants in Patients With Multisystem Inflammatory Syndrome in Children

Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

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