Myocardial ischemia, as well as the induction agents used in anesthesia, may cause
corrected QT interval (QTc) prolongation. The objective of this randomized,
double-blind trial was to determine the effects of high- vs
conventional-dose bolus rocuronium on QTc duration and the incidence of dysrhythmias
following anesthesia induction and intubation. Fifty patients about to undergo
coronary artery surgery were randomly allocated to receive conventional-dose (0.6
mg/kg, group C, n=25) or high-dose (1.2 mg/kg, group H, n=25) rocuronium after
induction with etomidate and fentanyl. QTc, heart rate, and mean arterial pressure
were recorded before induction (T0), after induction (T1), after rocuronium (just
before laryngoscopy; T2), 2 min after intubation (T3), and 5 min after intubation
(T4). The occurrence of dysrhythmias was recorded. In both groups, QTc was
significantly longer at T3 than at baseline [475 vs 429 ms in group
C (P=0.001), and 459 vs 434 ms in group H (P=0.005)]. The incidence
of dysrhythmias in group C (28%) and in group H (24%) was similar. The QTc after
high-dose rocuronium was not significantly longer than after conventional-dose
rocuronium in patients about to undergo coronary artery surgery who were induced with
etomidate and fentanyl. In both groups, compared with baseline, QTc was most
prolonged at 2 min after intubation, suggesting that QTc prolongation may be due to
the nociceptive stimulus of intubation.