Comparison of fresh autogenous with formalin preserved allogeneic bone grafts in rabbits

Mehra, Varun; Gill, SS; Dhillon, Mandeep Singh; Bhusnurmath, S. R.; Nagi, O. N.

doi:10.1007/bf00181711

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…Integration of autologous cortical bone grafts of the diaphysis of the radius and ulna were observed on radiographs in other studies after six and sixteen weeks 22 , 31 . Although there is a close relationship between revascularization of the bone graft and its integration, it was shown that incorporation of the cortical bone graft was not expected, even when fixed in a stable manner to a healthy bed, with good vascularization.…”

Section: Discussionmentioning

confidence: 80%

The Effect of 2-Butyl-Cyanoacrylate Adhesive in Osteotomies and Bone Grafts in Rabbits: Macroscopic and Radiographic Characteristics

Xavier

Leite

2012

Revista Brasileira de Ortopedia (English Edition)

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Objective: To evaluate the effect of butyl-2-cyanoacrylate tissue adhesive in osteotomies and bone grafts, with regard to macroscopic and radiographic characteristics. Methods: Forty-eight rabbits were used, randomly divided into four groups of 12 animals, with observation periods of two, four, eight and 16 weeks. Both thoracic limbs were operated in each animal and two osteotomies were performed in each of the radii, withdrawing a bone fragment (bone graft) of 1 cm in length. On one side, the bone graft was then replaced and a drop of adhesive was applied to each of the osteotomies. On the other side, the same procedure was performed without applying the adhesive. The rejection level for the nullity hypothesis was set at 0.05% or 5%. Results: Blue marks were present in all the surgical specimens in which adhesive was applied. From the fourth week onwards, there was absence of movement of the bone grafts with adhesive and control. In group A, in the proximal osteotomies with adhesive, there was less deviation of the bone graft (p = 0.02). In group C, the union (p = 0.03) and the integration of the bone graft (p = 0.02) were better in the proximal osteotomies with adhesive. Conclusions: The adhesive was not completely metabolized within 16 weeks. There was clinical consolidation of the osteotomies within four weeks. The adhesive stabilized the bone graft within the first weeks and did not interfere with the consolidation of the osteotomies, or the integration of the bone graft in radiographic observations.

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Section: Discussionmentioning

confidence: 80%

The Effect of 2-Butyl-Cyanoacrylate Adhesive in Osteotomies and Bone Grafts in Rabbits: Macroscopic and Radiographic Characteristics

Xavier

Leite

2012

Revista Brasileira de Ortopedia (English Edition)

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“…The rate of union using FPA was reported to be the same as autologous bone by Mehra et a/. 4 although the onset of union was delayed in FPA bone graft. We found our results with cancellous FPA bone graft comparable to autogenous bone graft.…”

Section: Discussionmentioning

confidence: 86%

“…The mechanism of action is believed to be protein molecule enlargement due to the reaction of formaldehyde with the reactive group of proteins>, Previous reports on the use of formalin preserved allograft have demonstrated its efficacy in animal models. Mehra et al 4 and Sharma et al 6 used FPA to bridge an osteoperiosteal gap in the ulnar diaphysis of rabbits. Gonzalves et al used it in the repair of mandibular defect in Wistar rats?…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Formalin Preserved Allogeneic Bone Graft as a Grafting Material

2000

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Formalin preserved allogeneic (FPA) bone graft was used in 18 patients with benign bone cavities, nine patients with malignant bone cavities, 12 patients with atrophic nonunion of fractures, seven with gap nonunion and 18 with comminuted fractures. The benign bone cavities were obliterated in 20 weeks and malignant cavities in 24 weeks. Union was obtained in atrophic ununited fractures in 29 weeks, in gap nonunion in 40 weeks and in comminuted fractures in 27 weeks. FPA is a simple, inexpensive and easily available alternative to autologous bone and to deep frozen bone in filling bone defects and enhancing fracture union.

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“…It has already been shown that autologous bone grafts could provide healing of such a defect in a similar model. [25][26][27] We decided not to study a group with BMC alone because this cannot be used in clinical cases for such large defects of a long bone. The cell suspension needs a rigid scaffold or a gel to be maintained in the defect to avoid dispersion of the cells and formation of ectopic bone.…”

Section: Discussionmentioning

confidence: 99%

Coral grafting supplemented with bone marrow

Louisia

Stromboni

Meunier

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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Limited success in regenerating large bone defects has been achieved by bridging them with osteoconductive materials. These substitutes lack the osteogenic and osteoinductive properties of bone autograft. A direct approach would be to stimulate osteogenesis in these biomaterials by the addition of fresh bone-marrow cells (BMC).We therefore created osteoperiosteal gaps 2 cm wide in the ulna of adult rabbits and either bridged them with coral alone (CC), coral supplemented with BMC, or left them empty. Coral was chosen as a scaffold because of its good biocompatibility and resorbability. In osteoperiosteal gaps bridged with coral only, the coral was invaded chiefly by fibrous tissue. It was insufficient to produce union after two months. In defects filled with coral and BMC an increase in osteogenesis was observed and the bone surface area was significantly higher compared with defects filled with coral alone. Bony union occurred in six out of six defects filled with coral and BMC after two months. An increase in the resorption of coral was also observed, suggesting that resorbing cells or their progenitors were present in bone marrow and survived the grafting procedure. Our findings have shown that supplementation of coral with BMC increased both the resorption of material and osteogenesis in defects of a clinical significance.

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Comparison of fresh autogenous with formalin preserved allogeneic bone grafts in rabbits

Cited by 3 publications

References 13 publications

The Effect of 2-Butyl-Cyanoacrylate Adhesive in Osteotomies and Bone Grafts in Rabbits: Macroscopic and Radiographic Characteristics

The Effect of 2-Butyl-Cyanoacrylate Adhesive in Osteotomies and Bone Grafts in Rabbits: Macroscopic and Radiographic Characteristics

Evaluation of Formalin Preserved Allogeneic Bone Graft as a Grafting Material

Coral grafting supplemented with bone marrow

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