Comparison of gadoxetic acid‐enhanced dynamic imaging and diffusion‐weighted imaging for the preoperative evaluation of colorectal liver metastases

Chung, Woo-Suk; Kim, Do Young; Chung, Yong Eun; Kim, Yeo-Eun; Park, Mi‐Suk; Choi, Jin Young; Kim, Ki Whang

doi:10.1002/jmri.22671

Cited by 82 publications

(39 citation statements)

References 31 publications

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“…7), was noteworthy. Previous studies have suggested that the combination of DWI with hepatospecific contrast-enhanced sequences may improve our ability to detect colorectal liver metastases [13][14][15][16][17][18]. However, these data were obtained in small, heterogenous series.…”

Section: Discussionmentioning

confidence: 96%

Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy

et al. 2012

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Objectives To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. Methods Thirty-two consecutive patients with a total of 166 liver lesions were retrospectively enrolled. Of the lesions, 144 (86.8 %) were metastatic at pathology. Three image sets (1, Gd-EOB-DTPA; 2, DWI; 3, combined Gd-EOB-DTPA and DWI) were independently reviewed by two observers. Statistical analysis was performed on a per-lesion basis. Results Evaluation of image set 1 correctly identified 127/ 166 lesions (accuracy 76.5 %; 95 % CI 69.3-82.7) and 106/ 144 metastases (sensitivity 73.6 %, 95 % CI 65.6-80.6). Evaluation of image set 2 correctly identified 108/166 (accuracy 65.1 %, 95 % CI 57.3-72.3) and 87/144 metastases (sensitivity of 60.4 %, 95 % CI 51.9-68.5). Evaluation of image set 3 correctly identified 148/166 (accuracy 89.2 %, 95 % CI 83.4-93.4) and 131/144 metastases (sensitivity 91 %, 95 % CI 85.1-95.1). Differences were statistically significant (P<0.001). Notably, similar results were obtained analysing only small lesions (<1 cm). Conclusions The combination of DWI with Gd-EOB-DTPAenhanced MRI imaging significantly increases the diagnostic accuracy and sensitivity in patients with colorectal liver metastases treated with preoperative chemotherapy, and it is particularly effective in the detection of small lesions. Key Points • Accurate detection of colorectal liver metastases is essential to determine resectability.• Almost 80 % of patients are candidates for neoadjuvant chemotherapic treatment at diagnosis. After chemotherapy, metastases usually decrease, and drug-induced liver steatosis may be present.• The sensitivity of imaging is significantly inferior to that in chemotherapy-naïve patients.• DWI combined with Gd-EOB-DTPA increases sensitivity in detecting small metastases after chemotherapy.

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Section: Discussionmentioning

confidence: 96%

Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy

et al. 2012

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“…Recently, gadoxetic acid (Gd-EOB-DTPA, Primovist®; Bayer Healthcare, Berlin, Germany), which is a hepatocyte-specific MR contrast agent, has received much attention as a promising contrast medium for the evaluation of liver metastases [16][17][18]. In addition, several studies have demonstrated that the combination of DWI and gadoxetic acid-enhanced MRI can improve the accuracy and sensitivity for the detection of liver metastasis, especially for small liver metastasis, as well as after preoperative chemotherapy [19][20][21][22][23]. However, to the best of our knowledge, there have been no large series studies regarding this issue or data on the diagnostic performance of MRI with gadoxetic acid for the detection of CRLM in patients with NAC.…”

Section: Introductionmentioning

confidence: 99%

Gadoxetic acid-enhanced MRI and diffusion-weighted imaging for the detection of colorectal liver metastases after neoadjuvant chemotherapy

Lee

Hur

et al. 2015

Eur Radiol

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“…Even for the primary detection of liver metastases, comparable results for DWI-and CE-MRI were reported in recently published studies [25][26][27][28][29]. Nevertheless, they stated the need for contrast-enhanced MR-imaging, especially in cases of PETnegative liver lesions with restricted diffusion in DW-Imaging, who often turned out to be FNH in the histopathological workup [12,16].…”

Section: Discussionmentioning

confidence: 49%

Qualitative and quantitative image analysis of CT and MR imaging in patients with neuroendocrine liver metastases in comparison to 68Ga-DOTATOC PET

Flechsig¹,

Zechmann²,

Schreiweis³

et al. 2015

European Journal of Radiology

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Comparison of gadoxetic acid‐enhanced dynamic imaging and diffusion‐weighted imaging for the preoperative evaluation of colorectal liver metastases

Cited by 82 publications

References 31 publications

Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy

Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy

Gadoxetic acid-enhanced MRI and diffusion-weighted imaging for the detection of colorectal liver metastases after neoadjuvant chemotherapy

Qualitative and quantitative image analysis of CT and MR imaging in patients with neuroendocrine liver metastases in comparison to 68Ga-DOTATOC PET

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