Comparison of Gastroesophageal Reflux Disease Symptoms and Proton Pump Inhibitor Response Using Gastroesophageal Reflux Disease Impact Scale Questionnaire

Jo, So Young; Kim, Nayoung; Lim, Ji Hwan; Shin, Cheol Min; Park, Young Soo; Lee, Dong Hoon; Jung, Hyun Chae

doi:10.5056/jnm.2013.19.1.61

Cited by 17 publications

(12 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The GIS is a validated questionnaire that was developed from systematic literature review and has been demonstrated to have good psychometric properties in diagnosis and is considered as a useful communication tool in managing GERD 21. GIS consists of 5 questions about symptoms and 4 questions about impact of symptoms on sleep, eating or drinking, job or daily activities and taking medication without prescription 22. Subjects answered each question by 4 scales; 3 point for 'daily', 2 for 'often', 1 for 'sometimes' and zero for 'never.'…”

Section: Methodsmentioning

confidence: 99%

Association of Sleep Dysfunction and Emotional Status With Gastroesophageal Reflux Disease in Korea

Kim¹,

Kim

Seo³

et al. 2013

J Neurogastroenterol Motil

Self Cite

View full text Add to dashboard Cite

Background/AimsSleep disturbances and emotional dysfunction are commonly associated with gastroeophageal reflux disease (GERD). The aims of this study were to evaluate GERD symptoms and disturbance in erosive reflux disease (ERD) and nonerosive reflux disease (NERD) patients, and to compare sleep dysfunction, depressive mood, anxiety and quality of life (QOL) among the control, ERD and NERD patients in Korea.MethodsThe Korean subjects were enrolled between 2010 and 2012, classified into 3 groups; the control group with no symptom and normal endoscopic findings, the ERD group with erosive esophagitis and the NERD group with more than one episode of heartburn or acid regurgitation per week, positive response to proton pump inhibitor, and normal endoscopic findings. Questionnaire included GERD symptoms, GERD impact scale (GIS) and daytime pathological sleepiness (Epworth sleepiness scale), sleep dysfunction (Pittsburgh sleep quality index, PSQI), depression and anxiety (Hospital anxiety and depression scale, HADS) and QOL (WHO quality of life scale abbreviated version, WHOQOL-BREF).ResultsA total of 217 subjects were enrolled as follows; control (n = 70), ERD (n = 70) and NERD (n = 77). Impact of symptom of GIS score was higher in the NERD (9.2 ± 0.4) than in the ERD (6.5 ± 0.3) group (P < 0.001). Sleep dysfunctions were more frequent in GERD than the control group (PSQI score [P = 0.021]). Anxiety subscale of HAD score was higher in NERD (7.0 ± 0.5, P = 0.002) and ERD (6.2 ± 0.7, P = 0.004) groups than control (4.3 ± 0.7) group. WHOQOL-BREF scores in NERD (54.9 ± 2.3) and ERD (57.8 ± 2.4) groups were significantly lower than those in the control group (63.8 ± 2.4) (P = 0.002; P = 0.014, respectively). ConclusionsThe patients with NERD than ERD suffered more from the symptoms and disturbance in Korea. Sleep dysfunction and anxiety mood were higher and QOL was decreased in GERD, especially in NERD, suggesting that those factors might affect the severity of NERD.

show abstract

Section: Methodsmentioning

confidence: 99%

Association of Sleep Dysfunction and Emotional Status With Gastroesophageal Reflux Disease in Korea

Kim¹,

Kim

Seo³

et al. 2013

J Neurogastroenterol Motil

Self Cite

View full text Add to dashboard Cite

show abstract

“…Diagnosis of Helicobacter pylori was performed by histology (by modified Giemsa staining), and Campylobacter -like organism (CLO) test (Delta West, Bentley, Australia), which were tested with the mucosa of antrum and corpus, respectively. The GERD symptoms were prospectively analyzed using GERD impact score 12. Patients with systemic diseases requiring chronic medication (except hypertension and diabetes mellitus) were excluded (1 patient with a history of gastrointestinal surgery and 1 patient with liver cirrhosis).…”

Section: Methodsmentioning

confidence: 99%

Predictable Marker for Regression of Barrett's Esophagus by Proton Pump Inhibitor Treatment in Korea

Jo¹,

Lee²,

Kim³

et al. 2013

J Neurogastroenterol Motil

Self Cite

View full text Add to dashboard Cite

Background/AimsThere has been no report regarding the regression of Barrett's esophagus (BE) by continuous treatment of proton pump inhibitor (PPI). The aim of this study was to determine the regression rate of BE by PPI and predictable markers related to regression.MethodsThirty-five patients diagnosed as BE were consecutively enrolled and most of them took continuous PPI. The 25 patients underwent endoscopic surveillance and received biopsy. If the specialized intestinal metaplasia (SIM) was lost at any point of surveillance and did not recur, the case was regarded as the regression group. The proportion of SIM was graded and the mucin phenotype was decided using immunohistochemistry for MUC2, MUC5AC and MUC6. To assess the cell proliferation indexes and the degree of intestinal maturation, immunohistochemistry for Ki67 and CDX2 were performed.ResultsThe regression of BE occurred in the 11 (44%) patients. The clinical and demographic factors showed no difference between the regression (n = 11) and persistence group (n = 14). The lower grade of SIM (P < 0.001) and gastric predominant mucin phenotype (P = 0.018) were more frequent, and the number of Ki67 positive cell per gland (P = 0.008) and the mean extent of CDX2 (P = 0.022) were lower in the regression group than in the persistence group.ConclusionsThe regression of BE by PPI treatment was frequent in Korea. The immunohistochemical detection of mucin phenotype, grade of SIM, Ki67 and CDX2 expression in Barrett's mucosa could be useful as a predictable marker for regression of SIM in BE.

show abstract

“…Previous reports have demonstrated that alcohol consumption was more frequent in patients with erosive GERD compared with NERD [23]. It is known that consumption of alcohol promotes acid regurgitation and causes GERD symptoms.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Potassium-Competitive Acid Blocker Non-Response in Patients with Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease

et al. 2017

View full text Add to dashboard Cite

Background/Aims: Approximately 20-40% of patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) treatment. The acid-inhibitory effect of vonoprazan, a novel potassium-competitive acid blocker (P-CAB), is significantly greater when compared to the effect of PPIs. We investigated the efficacy of vonoprazan treatment for PPI-refractory GERD and factors associated with P-CAB non-response. Methods: We enrolled 277 GERD patients receiving continuous PPI therapy. Subjects completed a self-report questionnaire including the frequency scale for the symptoms of GERD (FSSG). Patients with PPI-refractory GERD received 20 mg of vonoprazan once daily for 8 weeks. After that, subjects completed the same questionnaire, and the results were used to identify P-CAB responders and non-responders. Results: Twenty-eight patients were identified as P-CAB responders and 26 were non-responders. Vonoprazan treatment significantly decreased scores of FSSG, nighttime symptom, and Athens Insomnia Scale. Multivariate analysis demonstrated co-existing functional dyspepsia (FD; OR 4.94) and the presence of sleep disturbances (OR 4.34) was associated with P-CAB non-response, whereas alcohol consumption was inversely associated. Conclusions: Vonoprazan treatment might be appropriate as a promising new strategy for PPI-refractory GERD. Co-existing FD, sleep disturbances, and alcohol abstinence were significantly associated with P-CAB non-response. Other therapeutic options should be considered in patients with these factors.

show abstract

Comparison of Gastroesophageal Reflux Disease Symptoms and Proton Pump Inhibitor Response Using Gastroesophageal Reflux Disease Impact Scale Questionnaire

Cited by 17 publications

References 45 publications

Association of Sleep Dysfunction and Emotional Status With Gastroesophageal Reflux Disease in Korea

Association of Sleep Dysfunction and Emotional Status With Gastroesophageal Reflux Disease in Korea

Predictable Marker for Regression of Barrett's Esophagus by Proton Pump Inhibitor Treatment in Korea

Factors Associated with Potassium-Competitive Acid Blocker Non-Response in Patients with Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease

Contact Info

Product

Resources

About