Comparison of gemeprost and vaginal misoprostol in first trimester mifepristone-induced abortion

Alternatives to mifepristone for early medical abortion

“…In addition, a longer follow-up interval gives more information about success rates since late failures (in patients requiring surgical intervention for prolonged bleeding or infection after a diagnosis of complete abortion) are also included in the final analysis. A study protocol that evaluated patients 2 weeks and 3 months following administration of mifepristone found that the success rate decreased from 99% to 96% owing to surgical interventions in patients initially diagnosed as having had complete abortions [6].…”

A review of developments in medical termination of pregnancy

“…2004, RCOG 2004, Marions 2006). Gemeprost as the second phase medication is being superseded by misoprostol because of lower cost, stability at room temperature and the option of oral administration (Svendsen et al. 2005).…”

“…The second stage normally comprises administration of gemeprost or misoprostol. A retrospective study of 833 women admitted for first trimester abortion in Denmark received either gemeprost 1 mg (n ¼ 410) or 800lg misoprostol (n ¼ 423) (Svendsen et al 2005). The authors found gemeprost and misoprostol equally effective with the two-week follow-up showing 99% complete abortion rate.…”

Service provision for women undergoing termination of pregnancy: progress in Wales, UK

“…36 Mean cost per patient was US$1.48 (£0.98) for misoprostol and US$85.79 (£57.08) for gemeprost. 37 Based on this evidence, the sole Trust using gemeprost instead of misoprostol would need to justify its continued use.…”