during winter season of 2016-17 to study performance in and outside of poly-house to find out the most suitable and best cultivar, environment and interactions for growth, yield and quality of tomato fruits. The experiment was laid out in factorial randomized block design (R.B.D.) with three replications. Each replication consisted of eight treatment combinations viz., two tomato cultivars i.e., Pant Poly-house Tomato-2 (V1) and Pant Poly-house Hybrid Tomato -1 (V2), four environments (viz., E4-poly-house + spray of 2, 4-D), E3 (open + spray of 2, 4-D ), E2 (poly-house without spray) and E1 (open field without spray). Foliar spray of 2, 4-D @ 5 ppm concentration was applied as whole plant spray at 30, 45 and 60 days after transplanting of tomato seedlings. Results of investigation revealed that the cultivar V1 produced highest fruit yield which was 12.13% higher over V2. Among the environmental treatments, E4 produced 66.39, 78.64 271.39% higher fruit yield over treatment E3, E2, E1, respectively. Among the interactions, treatment V1E4 performed better for 10 characters whereas, V2E4 & V2E3 were better for 3 characters, and treatment V1E2 only for one character as compared to rest of the interactions. The treatment V1E4 gave 37.75% higher fruit yield than V2E4 and 84.44% over treatment V2E3 and 119.67% over V1E2.On the other hand, V2E4 produced 42.09% higher over V2E2 and 266.52% higher fruit yield over V2E1.Treatment V2E4 gave 33.89% higher over V2E3.