Comparison of gut microbiome profile in patients with schizophrenia and healthy controls - A plausible non-invasive biomarker?

Gokulakrishnan, Kuppan; Joyappa, Nikhil; Viswanath, Biju; Thirumoorthy, Chinnasamy; Sandhya, Narasimhan; Devarajan, Bharanidharan; Joseph, Ebin; David, Arul Kevin Daniel; Sharma, Sapna; Vasudevan, K; Sreeraj, Vanteemar S.; Holla, Bharath; Shivakumar, Venkataram; Debnath, Monojit; Venkatasubramanian, Ganesan; Varambally, Shivarama

doi:10.1016/j.jpsychires.2023.05.021

Cited by 9 publications

(1 citation statement)

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“…This phenomenon has also been considered as being associated with aging in other studies ( 70 , 71 ). A study observed a reverse up-regulation of Ruminococcus (genus) abundance in schizophrenia patients after medication ( 72 ). This observation coincide with what we found only in the untreated group.…”

Section: Discussionmentioning

confidence: 99%

Alterations of the gut microbiota in patients with schizophrenia

Li,

Tao,

Wang

et al. 2024

Front. Psychiatry

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IntroductionSchizophrenia is a complex psychiatric disorder, of which molecular pathogenesis remains largely unknown. Accumulating evidence suggest that gut microbiota may affect brain function via the complex gut-brain axis, which may be a potential contributor to schizophrenia. However, the alteration of gut microbiota showed high heterogeneity across different studies. Therefore, this study aims to identify the consistently altered gut microbial taxa associated with schizophrenia.MethodsWe conducted a systematic search and synthesis of the up-to-date human gut microbiome studies on schizophrenia, and performed vote counting analyses to identify consistently changed microbiota. Further, we investigated the effects of potential confounders on the alteration of gut microbiota.ResultsWe obtained 30 available clinical studies, and found that there was no strong evidence to support significant differences in α-diversity and β-diversity between schizophrenic patients and healthy controls. Among 428 differential gut microbial taxa collected from original studies, we found that 8 gut microbial taxa were consistently up-regulated in schizophrenic patients, including Proteobacteria, Gammaproteobacteria, Lactobacillaceae, Enterobacteriaceae, Lactobacillus, Succinivibrio, Prevotella and Acidaminococcus. While 5 taxa were consistently down-regulated in schizophrenia, including Fusicatenibacter, Faecalibacterium, Roseburia, Coprococcus and Anaerostipes.DiscussionThese findings suggested that gut microbial changes in patients with schizophrenia were characterized by the depletion of anti-inflammatory butyrate-producing genera, and the enrichment of certain opportunistic bacteria genera and probiotics. This study contributes to further understanding the role of gut microbiota in schizophrenia, and developing microbiota-based diagnosis and therapy for schizophrenia.

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Section: Discussionmentioning

confidence: 99%