Comparison of Heat Transfer Enhancement Between Magnetic and Gold Nanoparticles During HIFU Sonication

Devarakonda, Surendra B.; Myers, Matthew R.; Banerjee, Rupak K.

doi:10.1115/1.4040120

Cited by 13 publications

(7 citation statements)

References 32 publications

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“…According to Devarakonda et al ( 70 ), the adoption of magnetic nanomaterials (superparamagnetic iron oxide NPs; 0.047% w/v) halves the HIFU irradiation dose required to obtain 13 mm 3 tumour destruction volume, significantly reducing the side effects caused by high HIFU doses ( 70 ). They also discovered that the thermal enhancing efficacy of magnetic nanomaterials was higher than that of gold NPs, which are another HIFU hyperthermal candidate, making magnetic NPs clinically preferable ( 71 ). However, the mechanism by which magnetic NPs enhance HIFU cancer therapy remains unclear.…”

Section: Nano-therapeutics For Hifu-based Cancer Treatmentmentioning

confidence: 99%

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

Zheng¹,

Xia²,

Huang³

et al. 2023

Exp Ther Med

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High-intensity focused ultrasound (HIFU) is a promising and representative non-invasive therapeutic method for treating cancer with a high degree of efficacy. This non-invasive method induces tumour cell necrosis by increasing the local temperature and mechanical pressure. However, the clinical application of HIFU is limited given its low penetration depth and the incidence of off-target side effects. With their promising structural adjustability and targeting ability, nanomedicines have been adopted to improve the ablative efficacy of HIFU in the treatment of cancer. By selectively changing the acoustic environment (tissue structure, density and blood supply) of tumour tissue, these nanomedicines may allow for lower HIFU doses and treatment duration, while additionally achieving a higher degree of efficacy. The use of nanomedicines may also enable cancer theranostics of HIFU, allowing for precise cancer therapeutics. The present review aimed to provide an overview of advances in nanomedicines for HIFU cancer treatment and theranostics, stating their current limitations and future perspectives. Contents 1. Introduction 2. Nano-therapeutics for HIFU-based cancer treatment 3. Nano-based HIFU cancer theranostics 4. Conclusions and future perspectives

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Section: Nano-therapeutics For Hifu-based Cancer Treatmentmentioning

confidence: 99%

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

Zheng¹,

Xia²,

Huang³

et al. 2023

Exp Ther Med

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“…While many preclinical studies demonstrated the effects of MNPs and AuNPs, the relative advantages of MNPs over AuNPs during the HIFU thermal ablation also have been reported by experimental studies. Devarakonda et al [38] conducted an experimental analysis using tissue-mimicking phantoms and compared the performances of MNPs and AuNPs for the HIFU thermal ablation. They showed that MNPs had much greater effect than AuNPs in enhancing the thermal mechanism of HIFU and consequently are better agents for the HIFU hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticles-enhanced focused ultrasound heating: size effect, mechanism, and performance analysis

Sadeghi-Goughari¹,

Jeon²,

Kwon³

2020

Nanotechnology

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High intensity focused ultrasound (HIFU) has attracted great interest as a new energy-based technique to treat disordered tissues, such as tumors, through a hyperthermal mechanism using ultrasonic waves. However, long treatment times and collateral damage to healthy tissues due to high acoustic powers are still challenges for the clinical application of HIFU. One possible strategy to enhance the deposition efficiency of HIFU at the tumor site is to employ magnetic nanoparticles (MNPs) as ultrasound absorption agents for the thermal therapy. The objectives of the current study are threefold: (i) to examine the effects of MNP features, including the size and volume concentration, on the thermal mechanism of HIFU (ii) to investigate the performance of MNPs as they were exposed to ultrasound fields at different ranges of power and frequency (iii) and to study the interaction mechanism between MNPs and ultrasonic waves during the MNPsenhanced HIFU process. To this end, we developed an ultrasound-guided HIFU system to conduct an in vitro experimental study on tissue phantoms containing MNPs of different sizes and volume concentrations. A set of HIFU parameters such as temperature rise and the rate of absorbed energy was monitored to examine the role of MNPs during the NPs-enhanced HIFU thermal procedure. Results showed that the MNPs significantly improved the thermal effect of HIFU by enhancing the rate of energy converted to heat and the temperature rise at the focal region. Moreover, it was demonstrated that the increase of MNP size and volume concentration greatly enhanced the HIFU parameters; the effects of MNPs were further improved by increasing the power and frequency of acoustic field.

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“…The model predicted higher efficiency for heat production in a medium with iron oxide nanoparticles having enough high particle volume fraction when compared to the case when gold nanoparticles are imbedded in a medium. The authors confirmed this result experimentally by measuring the temperature rise during ultrasonic heating in TMMs doped with gold and iron oxide nanoparticles . Another advantage of using magnetic particles is that they can be moved by changing the magnetic field, for example, by manipulating the external magnetic field, before sonication, so that they can be brought to the target in damaged tissue in the body or in a place requiring drug action …”

Section: Introductionmentioning

confidence: 99%

“…The authors confirmed this result experimentally by measuring the temperature rise during ultrasonic heating in TMMs doped with gold and iron oxide nanoparticles. 12 Another advantage of using magnetic particles is that they can be moved by changing the magnetic field, for example, by manipulating the external magnetic field, before sonication, so that they can be brought to the target in damaged tissue in the body or in a place requiring drug action. 13 The ultrasonic absorption enhancement by the addition of magnetic iron oxide nanoparticles to agar gel TMMs was discussed in relation to the pure agar gel and different nanoparticle fractions.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

et al. 2019

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Purpose Nowadays, the improvement of ultrasonic hyperthermia therapy is often achieved by adding hard particles to the sonicated medium in order to increase the heating efficiency. The explanation of the phenomenon of ultrasonic heating still requires testing on tissue mimicking materials (TMMs), enriched with particles of different sizes and physical properties. Our goal was to determine, by comparing their quantitative acoustic properties, which TMMs, with magnetic micro‐ or nanoparticles, convert more ultrasonic energy into heat or which of the particles embedded in the agar gel act as more effective thermal sonosensitizers. Methods We manufactured a pure agar gel and an agar gel with the addition of magnetic micro‐ or nanoparticles in two proportions of 8 and 16 mg/ml. Ultrasound quantitative techniques, the broadband reflection substitution technique and backscattered spectrum analysis were used to characterize the samples by speed of sound (SOS), frequency‐dependent attenuation, and backscattering coefficients. The integrated backscattering coefficients were also calculated. The quantitative parameters, scattering, and attenuation coefficients of ultrasound in phantoms with micro‐ and nanoparticles were estimated. Based on the attenuation and scattering of ultrasound in the samples, the ultrasonic energy absorption, which determines the heating efficiency, was evaluated. Additionally, the temperature increase during sonication of the phantoms by an ultrasonic beam was directly measured using thermocouples. Results The density of the materials with nanoparticles was higher than for the materials with microparticles with the same fractions of particles. The SOS for all materials ranged from 1489 to 1499 m/s. The attenuation in the whole frequency range (3–8 MHz) was higher for the materials with nanoparticles than for the materials with microparticles. For the materials with the lower content (8 mg/ml) of particles, the attenuation coefficient was 0.2 dB/(MHz cm). For the 16 mg/ml concentration of nanoparticles and microparticles, the attenuation coefficients were 0.66 and 0.45 dB/(MHz cm), respectively. The value of backscattering coefficient in the whole frequency range was greater for the materials with microparticles than for the materials with nanoparticles. The values of the integrated backscattering coefficient were 0.05 and 0.08 1/m for the materials with nanoparticles and 0.46 and 0.82 1/m for the materials with microparticles and concentrations of 8 and 16 mg/ml, respectively. The rates of temperature increase in the first 3 s due to ultrasonic heating were higher for the materials with nanoparticles than for the materials with microparticles. Conclusions Based on acoustical measurements, we confirmed that all materials can be used as tissue phantoms in the study of ultrasonic hyperthermia, as their properties were in the range of soft tissue properties. We found that the nanoparticle‐doped materials had greater attenuation and smaller scattering of ultrasound than the materials with microparticles,...

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Comparison of Heat Transfer Enhancement Between Magnetic and Gold Nanoparticles During HIFU Sonication

Cited by 13 publications

References 32 publications

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

Magnetic nanoparticles-enhanced focused ultrasound heating: size effect, mechanism, and performance analysis

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

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