Comparison of Helicobacter pylori Detection Methods: It’s Association with Leukocytosis and Monocytosis

Abstract

<jats:sec> <jats:title>Background:</jats:title> <jats:p> Helicobacter pylori is a slow-growing micro-aerophilic gram-negative organism found in stomach and duodenum. It is also associated with a number of stomach-duodenal diseases.</jats:p> </jats:sec> <jats:sec> <jats:title>Material and Methods:</jats:title> <jats:p> There are invasive and non-invasive methods for detecting Helicobacter pylori infections. In a 13- months period, 101 patients with clinical signs of infection confirmed by biopsy and Rapid Urease test as well as culture were included to this study.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p> There were significant correlations between breath urease test, anti-Helicobacter pylori serum IgG and IgA as well as fecal Helicobacter pylori Ag with gold standard method,(P=0.001) Moreover, there was significant correlation between monocytosis (P= 0.05) and gold standard method.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>Based on studies conducted on patients with Helicobacter pylori infection, noninvasive diagnostics methods can be useful in the diagnosis of Helicobacter infections rather than evaluating anti-Helicobacter pylori serum IgM and also increased blood monocytes could be a reliable confirmation for detection. Furthermore, showed monocytosis must be considered as a Helicobacter pylori infection at first step in area with high infected percentage.</jats:p> </jats:sec>

<p>Observation of Changes in <em>Helicobacter pylori</em> Antigen and Antibody Positivity According to Non-Invasive Tests Before and After <em>Helicobacter pylori</em> Eradication Therapy in Symptomatic Patients</p>

“…16 Also, a recent study has shown significant correlation between H. pylori infection and monocytosis in areas with high infection percentage. 17 But there is no definite method as a gold standard to detect H. pylori infection. 18,19 To date, invasive tests such as RUT, histology and culture have been considered as the standard methods, but all of them require endoscopy, which is expensive and inconvenient, has a risk of complications and is only available in gastroenterology departments of tertiary level hospitals.…”

“… 16 Also, a recent study has shown significant correlation between H. pylori infection and monocytosis in areas with high infection percentage. 17 But there is no definite method as a gold standard to detect H. pylori infection. 18 , 19 …”