Comparison of Immunogenic Rna Extracted From Peritoneal Exudate Cells and Kupffer Cells of the Rat

Archer, Stanley J.; Wust, Carl J.

doi:10.1111/j.1749-6632.1973.tb47487.x

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Kupffer cell blockade influences hepatic and splenic uptake as well as antibody production in the same way (Souhami, 1972;Souhami et al, 1975). Normally functioning Kupffer cells destroy the immunogenicity of phagocytised antigens (Inchley, 1969;Franzl, 1972;Archer and Wust, 1973). The decreased hepatic uptake and elimination of antigens resulting in a spillover of antigen to antibody producing sites Received for publication 14 July 1976 28 such as the spleen is now considered the main cause for the increased antibody production and hypergammaglobulinaemia in cirrhosis (Bj0rneboe et al, 1972;Triger et al, 1972;Prytz et al, 1974).…”

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confidence: 99%

Correlation between hepatic morphology and immunoglobulins and antibodies to Escherichia coli in cirrhosis.

Prytz¹,

Bjørneboe²,

Christoffersen³

et al. 1977

Gut

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SUMMARY Increased antibody production and hypergammaglobulinaemia in cirrhosis are probably to a large extent due to decreased hepatic extraction of antigens. The decreased extraction is presumably related to changed microcirculation caused by damaged anatomical structure of the liver. It is therefore to be expected that immunoglobulin and antibody levels in serum in cirrhotic patients are related to the degree of certain morphological changes of the liver. This hypothesis has been tested. In 50 patients with cirrhosis, 28 alcoholics and 22 non-alcoholics, the degree of architectural destruction, the degree of fibrosis, the degree of fatty infiltration, and the degree of 'activity' were compared with immunoglobulins G, A, and M and E. coli 0 antibody levels. The comparison was carried out within each of the aetiological groups. Identical relationships were found in both groups. Patients with completely destroyed lobular architecture had higher levels of E. coli 0 antibodies than patients with partly destroyed architecture. Patients with severe fibrosis had higher IgA and E. coli 0 antibody levels than patients with moderate or slight fibrosis. Patients with moderate and severe steatosis and patients with no or slight steatosis had the same immunoglobulin and E. coli O antibody levels. Patients with active cirrhosis had higher IgG levels than patients with inactive cirrhosis. When architectural destruction and fibrosis were combined significantly higher IgG, IgA, IgM, and E. coli antibodies were found in the group with the most severe changes. These findings support the hypothesis that immunoglobulin and antibody levels are related to the degree of morphological changes in the liver-namely, destruction of lobular architecture, fibrosis, and 'activity'.

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confidence: 99%

Correlation between hepatic morphology and immunoglobulins and antibodies to Escherichia coli in cirrhosis.

Prytz¹,

Bjørneboe²,

Christoffersen³

et al. 1977

Gut

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Characterization of Macrophage Dysfunction in Rodent Malaria

Loose

1984

Journal of Leukocyte Biology

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Immunosuppression in malaria has been attributed, in part, to alterations in macrophage function. The present study was undertaken in an attempt to characterize the dysfunction and to determine if it is regional or if it occurs in different populations of macrophages. The resting O2 consumption of either hepatic, splenic, or peritoneal macrophages or polymorphonuclear neutrophils (PMNs) was unaltered by the malaria infection. However, the respiratory burst was significantly enhanced in the three macrophage populations but not in the PMNs. A significant increase in their phagocytic capacity and microbicidal activity was noted for hepatic and peritoneal but not splenic macrophages or PMNs. The malaria-infected mice had a marked decrease in serum antibody and splenic plaque response to bovine serum albumin (BSA) but not to keyhole limpet hemocyanin (KLH). Following an in vitro incubation with BSA, splenic macrophages from infected mice were not able to induce an antibody response when injected into normal mice. However, following incubation with KLH splenic macrophages could induce an adequate response in normal mice. This ability of macrophages from malaria-infected mice to transfer (or induce) a response in normal mice appeared to correlate with the amount of antigen digested, or perhaps retained, by the cells, i.e., BSA digestion was significantly less than KLH. These results indicate that the macrophage dysfunction in malaria is distinct depending on the tissue population that the macrophage is obtained from and that the impaired antibody response may be restricted to antigens requiring macrophage processing.

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The mononuclear phagocytic functions of the liver

Bjørneboe¹,

Prytz²

1976

Immunological Aspects of the Liver and Gastrointestinal Tract

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Comparison of Immunogenic Rna Extracted From Peritoneal Exudate Cells and Kupffer Cells of the Rat

Cited by 3 publications

References 22 publications

Correlation between hepatic morphology and immunoglobulins and antibodies to Escherichia coli in cirrhosis.

Correlation between hepatic morphology and immunoglobulins and antibodies to Escherichia coli in cirrhosis.

Characterization of Macrophage Dysfunction in Rodent Malaria

The mononuclear phagocytic functions of the liver

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