The mononuclear phagocytic functions of the liver

Bjørneboe, M.; Prytz, Hanne

doi:10.1007/978-94-011-6150-3_7

Cited by 8 publications

(3 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of interest was the high LIP of IgA in AH, because one proposed explanation of the raised serum level of IgA in AH is impaired hepatic transport of IgA into bile (24). The present data, however, show that intrahepatic synthesis of IgA could make a substantial contribution to raised serum levels, as suggested recently (25). It is not clear why the high LIP for IgA is specific for AH, but this is consistent with the coexisting elevation of serum IgA levels.…”

Section: Discussionsupporting

confidence: 64%

Intrahepatic synthesis of immunoglobulin in liver disease

Kronborg

Knopf

Bhathal

et al. 1982

Liver

View full text Add to dashboard Cite

ABSTRACT— Patterns of intrahepatic immunoglobulin production were investigated by an in vitro biosynthetic labelling technique which measured the rate of Ig production in liver biopsy fragments. This technique depends on the incorporation of 3H‐leucine into proteins synthesized by cells in the biopsy fragment and subsequently released into the culture medium, and precipitation of Ig with monospecific antisera. Intrahepatic Ig production was expressed as counts of radioactivity precipitated/g of liver tissue/24 h. Mean values were high in various inflammatory diseases of the liver, including alcoholic hepatitis (AH) (17 cases), IgG, 87.8, IgA, 105.6 and IgM, 14.7, chronic active hepatitis (CAH) (19 cases), IgG, 86.0, IgA, 56:1 and IgM, 12.6, and acute viral hepatitis (3 cases), IgG, 116.0, IgA, 61.0 and IgM, 32.0, but low in histologically normal livers (6 cases), IgG, 4.5, IgA, 4.8 and IgM, 4.7, alcoholic fatty liver (11 cases), IgG, 9.4, IgA, 11.4 and IgM, 7.1, and miscellaneous non‐inflammatory conditions (10 cases), IgG, 8.7, IgA, 11.1 and IgM, 5.0. Photomicrographs were used to measure the density of plasma cells, expressed as cells/mm2 of liver biopsy tissue: mean counts were for AH 5.1, CAH 16.2 and normal liver 0.0. Intrahepatic Ig production in vitro did not correlate with the density of plasma cells in biopsy samples from cases of AH or CAH, nor with serum Ig levels.

show abstract

Section: Discussionsupporting

confidence: 64%

Intrahepatic synthesis of immunoglobulin in liver disease

Kronborg

Knopf

Bhathal

et al. 1982

Liver

View full text Add to dashboard Cite

show abstract

“…Van Marck [8] reported enhanced glomerular immune com plex deposition in mice after the development of porto systemic collateral circulation. The liver comprises more than 90% of all phagocytic cells of the body [21] and occupies a strategic position for the elimination or clear ance from the portal blood of antigens, immune com plexes or endotoxins [22]. Invasion of the liver tissue by granuloma, inflammatory cell infiltration and amyloid, on one hand, and portosystemic collaterals leading to shunting of blood directly to systemic circulation, on the other hand, will lead to diversion of immune complexes to the systemic circulation where they may be trapped by the renal glomeruli.…”

Section: Discussionmentioning

confidence: 99%

<i>Schistosoma mansoni </i>Nephropathy in Syrian Golden Hamsters: Effect of Dose and Duration of Infection

Sobh

Moustafa

Ramzy

et al. 1991

Nephron

View full text Add to dashboard Cite

In this work, 180 golden hamsters were infected with Schistosoma mansoni and 30 hamsters matched for age and sex served as controls. According to the number of injected cercariae, infected hamsters were divided into six main groups (20, 50,100,150, 200 and 250 cercariae). Each group was divided into five subgroups, according to the duration of infection after which animals were sacrificed (4,6,8,12 and 24 weeks). Control and infected hamsters were subjected to laboratory evaluations (serum creatinine, blood urea nitrogen, cholesterol, albumin, total protein and urine protein concentration) and histopathologic examinations of kidney and liver tissues. A significant proteinuria, hypoalbuminemia and hypercholesterolemia was observed in schistosome infected (50 cercariae or more) but not in the controls and the group infected with 20 cercariae. There was a significant correlation between these changes and duration of infection and the number of adult worm recovered from the mesenteric circulation at the end of the experiments. Histopathologic evaluation showed appearance of the circulating schistosome antigens, circulating anodic antigen (CAA) and circulating cathodic antigen (CCA), and of IgG glomerular deposits by the 6th week following infection; mesangial hypercellularity appeared early after infection (6–8 weeks), renal amyloid deposition appeared later (8–12 weeks). Egg antigens were not detected in the renal glomeruli. There was a significant correlation between the pathologic changes and duration of infection and the number of recovered adult worms from the mesenteric circulation. No histopathologic lesions were detected in controls and the group injected with 20 cercariae. A significant correlation was found between hepatic periportal fibrosis, amyloidosis and immune complex, deposition in the renal glomeruli. Hamsters did not tolerate infection with 150 cercariae or more for more than 12 weeks, and 20 cercariae caused no detectable glomerular disease. From this study, we concluded that S. mansoni infection causes nephropathy in the Syrian golden hamster. The disease became biochemically and histopathologically manifest by the 6th week following infection. Both immune complex deposition and renal amyloidosis stand as major pathogenic mechanisms. CAA and CCA are the major responsible antigens. Hepatic disease has an impact on the kidney lesion. 50 cercariae are the best dose to produce disease without early death of the animal. There is a significant correlation between the kidney disease and the duration and the load of S. mansoni infection.

show abstract

“…The mechanism responsible for hyperglobulinaemia in chronic liver disease probably has many factors. With portosystemic shunting, gut‐derived foreign antigens may bypass the phagocytic Kupffer cells and stimulate antibody formation in the spleen and bone marrow 13 . In addition, the cirrhotic liver may have difficulty separating immunogen (aggregated protein) from tolerogen (native protein).…”

Section: Reportmentioning

confidence: 99%

Waldenström's macroglobulinaemia presenting as reticulate purpura and bullae in a patient with hepatitis B virus infection

Cho

Chang²,

Kim

et al. 2001

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

Cutaneous manifestations of Waldenström's macroglobulinaemia (WM) include purpura, ulcers, urticaria, leukocytoclastic vasculitis, and immunobullous dermatoses. No association has been reported previously of WM and hepatitis B virus (HBV) infection. A 40-year-old female HBV carrier was admitted to hospital because of generalized oedema, oliguria, haematuria, hypertension, fever and blood-tinged sputum. Cutaneous manifestations included generalized petechiae, palpable purpura mainly on the legs, multiple necrotic ulcerations and gangrenous changes on the toes, and necrotic, giant confluent reticulate purpura on the trunk surmounted by several tense bullae. Laboratory investigations revealed monoclonal gammopathy of IgM kappa type (6.7 g/L), membranoproliferative glomerulonephritis associated with HBV infection, Bence Jones proteinuria, and an increased number of abnormal plasmacytoid cells in the bone marrow. Pathologic examination demonstrated immune complex-mediated vasculitis with deposits of IgM in the walls of dermal vessels and secondary subepidermal bulla formation. HBV infection may have caused WM or modified the clinical course in this fatal case.

show abstract

The mononuclear phagocytic functions of the liver

Cited by 8 publications

References 122 publications

Intrahepatic synthesis of immunoglobulin in liver disease

Intrahepatic synthesis of immunoglobulin in liver disease

<i>Schistosoma mansoni </i>Nephropathy in Syrian Golden Hamsters: Effect of Dose and Duration of Infection

Waldenström's macroglobulinaemia presenting as reticulate purpura and bullae in a patient with hepatitis B virus infection

Contact Info

Product

Resources

About