Comparison of Imprint Cytology and Frozen Section Techniques at Intraoperative Diagnosis: 381 Cases

Abstract

In this study our major goal is to establish which one of intraope:rative techniques; frozen seetion and imprint cytology is supe:dor and to assess the accuracy of the each of the in~ traoperative techniques. 381 surgical biopsies sent to our pathology laboratory from di:fferent dinks, imprint pre-peraHons and frozen sedions were made intıraoperatively, between 1992 March-1995 January. Intraoperative results based on imprint cytology and frozen seetion tecchniques were compared by the fina! diaguoses based on paraffin-embedded b lock sedions.On overall f:rozen seetion diagnoses we had 254 tme positive, 104 t.rue negative, 14 false positive, 9 false negative diagnoses. Positive predictive value was 94.6% and the negative predktive vaule89.7 %, and the accuracy was 93.9% On overall imprint cytology diagnoses we had true positive 261, tme negative 101, false posHive8, false negative 11 diagnoses. Positive predidive values was 97.2% and the negative predictive va1ues 90.1 % and the accumcy was 95%Diagnostic accuracy of the each technique was evaluated by chea-square test on both ma-Hgmmt and benign cases (p> 0.05). In order to determine wich one was superior binomial test was used. (p> 0.05). There was no signHicant dif:fereuce in accu:racy.