Comparison of IMPROVE, modified IMPROVE, IMPROVEDD, Padua and CHA2DS2-VASC risk scores for venous and arterial thrombotic events prediction in hospitalized COVID-19 patients

Lucijanić, Marko; Jurin, Ivana; Sedinić, Martina; Sorić, Ena; Sabljić, Anica; Krečak, Ivan; Mitrović, Joško; Marelic, Daniela; Kremer, Zvonimir; Hadžibegović, Irzal; Lucijanić, Tomo; Kušec, Rajko

doi:10.1016/j.thromres.2022.04.009

Cited by 3 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several prognostic scores for VTE developed prior to the pandemic found their place in clinical decision making in the COVID-19 context. Neither of them seems to demonstrate acceptable discriminatory properties [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients

Lucijanic,

Tjesic-Drinkovic,

Piskac Zivkovic

et al. 2023

Life

Self Cite

View full text Add to dashboard Cite

Thromboprophylaxis is a mainstay of treatment of hospitalized COVID-19 patients, due to the high occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated a cohort of 4014 consecutively hospitalized COVID-19 patients treated in a tertiary-level institution in the period 3/2020–3/2021. Bleeding of any kind was documented in 322 (8%) and major bleeding in 129 (3.2%) patients. A total of 129 (40.1%) bleeding events were present at the time of hospital admission, and 193 (59.9%) occurred during hospitalization. In the multivariate logistic regression analysis, intensive-care-unit treatment (adjusted odds ratio (aOR) 6.55; p < 0.001), atrial fibrillation (aOR 2.55; p = 0.029), higher white-blood-cell count (WBC) (aOR 1.03; p = 0.021), lower hemoglobin (aOR 0.97; p = 0.002) and history of bleeding (aOR 17.39; p < 0.001) were recognized as mutually independent predictors of major bleeding. Major bleeding was significantly associated with increased in-hospital mortality compared to non-major-bleeding patients (59.7% vs. 34.8%, p < 0.001), especially if occurring during hospitalization. Median time from major bleeding to death was 5 days. Bleeding events are frequent in hospitalized COVID-19 patients, with a significant proportion of patients presenting at the time of hospital admission, and others almost universally exposed to anticoagulant and corticosteroid therapies. Major bleeding is associated with high mortality, especially if occurring during hospitalization. The recognition of patients at risk and implementation of timely interventions are of high clinical importance.

show abstract

Section: Introductionmentioning

confidence: 99%

Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients

Lucijanic,

Tjesic-Drinkovic,

Piskac Zivkovic

et al. 2023

Life

Self Cite

View full text Add to dashboard Cite

show abstract

Extended post-discharge thromboprophylaxis in hospitalized COVID-19 patients

Spyropoulos

2022

Expert Review of Hematology

View full text Add to dashboard Cite

The Prevalence of Deep Vein Thrombosis and Associated Risk Factors Among Patients with COVID-19 in the North of Iran

et al. 2023

View full text Add to dashboard Cite

Aim: We aimed to investigate the associated risk factors of deep vein thrombosis (DVT) among COVID-19 patients. Materials & methods: In this cross-sectional study the demographical data and clinical characteristics of 382 COVID-19 patients were collected and analyzed. Results: The DVT was observed in 53 patients (14.1%). The rate of death was significantly associated with the incidence of DVT, 48.1 versus 32.2% in non-DVT cases; p = 0.034). Also, BMI (p = 0.0001), renal failure (p = 0.001), lower-limb edema (p = 0.0001) and intubation (p = 0.004) were associated with the risk of DVT. Conclusion: COVID-19 patients with a higher BMI, renal failure, lower-limb edema and need for intubation were at a higher risk of DVT.

show abstract

Comparison of IMPROVE, modified IMPROVE, IMPROVEDD, Padua and CHA2DS2-VASC risk scores for venous and arterial thrombotic events prediction in hospitalized COVID-19 patients

Cited by 3 publications

References 10 publications

Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients

Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients

Extended post-discharge thromboprophylaxis in hospitalized COVID-19 patients

The Prevalence of Deep Vein Thrombosis and Associated Risk Factors Among Patients with COVID-19 in the North of Iran

Contact Info

Product

Resources

About