Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung

McCarthy, Claire E.; Duffney, Parker F.; Wyatt, Jeffrey D.; Thatcher, Thomas H.; Phipps, Richard P.; Sime, Patricia J.

doi:10.1016/j.tiv.2017.05.021

Cited by 16 publications

(15 citation statements)

References 48 publications

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“…McCarthy et al, found that in pneumocytes wood smoke activates the aryl hydrocarbon receptor [ 87 ]. They did not inhibit hydrocarbon receptor signaling so it is not possible to ascertain the extent of the involvement of signaling via this receptor in response to biomass smoke.…”

Section: Other Potential Mechanismsmentioning

confidence: 99%

“…An alternative is to use systems where epithelial cells are cultured at an air liquid interface and expose these to gaseous biomass. McCarthy et al made dung cigarettes, and utilised a commercial smoking machine (Baumgartner-Jaeger CSM2072i, CH Technologies, Westwood, NJ, USA) to generate smoke and expose small airway epithelial cells, which had been at air: liquid interface for 24 h [ 87 ]. The obvious drawback to this particular system is that cigarettes were made with a filter, as used in a tobacco cigarette.…”

Section: How Should In Vitro and In Vivo Models Of Biomass Smoke mentioning

confidence: 99%

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Evidence of Biomass Smoke Exposure as a Causative Factor for the Development of COPD

Capistrano

Reyk

Chen

et al. 2017

Toxics

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Chronic obstructive pulmonary disease (COPD) is a progressive disease of the lungs characterised by chronic inflammation, obstruction of airways, and destruction of the parenchyma (emphysema). These changes gradually impair lung function and prevent normal breathing. In 2002, COPD was the fifth leading cause of death, and is estimated by the World Health Organisation (WHO) to become the third by 2020. Cigarette smokers are thought to be the most at risk of developing COPD. However, recent studies have shown that people with life-long exposure to biomass smoke are also at high risk of developing COPD. Most common in developing countries, biomass fuels such as wood and coal are used for cooking and heating indoors on a daily basis. Women and children have the highest amounts of exposures and are therefore more likely to develop the disease. Despite epidemiological studies providing evidence of the causative relationship between biomass smoke and COPD, there are still limited mechanistic studies on how biomass smoke causes, and contributes to the progression of COPD. This review will focus upon why biomass fuels are used, and their relationship to COPD. It will also suggest methodological approaches to model biomass exposure in vitro and in vivo.

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Section: Other Potential Mechanismsmentioning

confidence: 99%

Section: How Should In Vitro and In Vivo Models Of Biomass Smoke mentioning

confidence: 99%

Evidence of Biomass Smoke Exposure as a Causative Factor for the Development of COPD

Capistrano

Reyk

Chen

et al. 2017

Toxics

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“…Understanding the mechanisms underlying smoke-related health effects, such susceptibility to pulmonary infection and chronic lung disease, is not thoroughly understood, but such knowledge is key in providing biological evidence that public health interventions are needed to address the harm associated with the use of this fuel source. Toxicological studies are however making progress, characterising heightened inflammatory responses and impaired immune defences [ 52 , 53 , 55 ], and in doing so, suggest a mechanism by which HAP can directly cause lung diseases and promote increased susceptibility to infection. For example, in providing direct evidence that the use of cleaner burning cookstoves by women reduces alveolar macrophage black carbon loading, Whitehouse et al .…”

Section: Discussionmentioning

confidence: 99%

“…Subchronic exposures (50 μg × 3/week for 8 weeks, nose aspiration), however, induced eosinophilic inflammation, PM-specific antibody responses and alveolar destruction, which was greatest in wood PM-exposed mice. The potentially greater toxicity of cow dung biomass smoke, on the basis of oxidative capacity, particulates per mass of fuel burned and concentrations of microbial products, compared to other combustion products [ 49 , 53 , 54 ], has prompted an examination of six different types of dung biomass smoke on lung cells [ 55 ]. Since the type of animal dung used varies widely depending on local agro-geography, the types tested included horse ( Equus caballus ), US domestic cow ( Bos taurus taurus ), Indian domestic cow ( Bos taurus indicus ), African elephant ( Loxodonta africana ), goat ( Capra hircus ) and white rhinoceros ( Ceratotherium simum ).…”

Section: Household Air Pollutionmentioning

confidence: 99%

Global nature of airborne particle toxicity and health effects: a focus on megacities, wildfires, dust storms and residential biomass burning

Kelly

Fussell

2020

Toxicology Research

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Abstract Since air pollutants are difficult and expensive to control, a strong scientific underpinning to policies is needed to guide mitigation aimed at reducing the current burden on public health. Much of the evidence concerning hazard identification and risk quantification related to air pollution comes from epidemiological studies. This must be reinforced with mechanistic confirmation to infer causality. In this review we focus on data generated from four contrasting sources of particulate air pollution that result in high population exposures and thus where there remains an unmet need to protect health: urban air pollution in developing megacities, household biomass combustion, wildfires and desert dust storms. Taking each in turn, appropriate measures to protect populations will involve advocating smart cities and addressing economic and behavioural barriers to sustained adoption of clean stoves and fuels. Like all natural hazards, wildfires and dust storms are a feature of the landscape that cannot be removed. However, many efforts from emission containment (land/fire management practices), exposure avoidance and identifying susceptible populations can be taken to prepare for air pollution episodes and ensure people are out of harm’s way when conditions are life-threatening. Communities residing in areas affected by unhealthy concentrations of any airborne particles will benefit from optimum communication via public awareness campaigns, designed to empower people to modify behaviour in a way that improves their health as well as the quality of the air they breathe.

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“…However, other studies have not reproduced these conclusions and most probably this is related to the lack of standardization of the assays, the characteristics of the exposure to biomass and the cells and tissues examined. The axis: stress, autoimmunity and mitochondrial dysfunction already clearly involved in the pathogenesis of COPD associated with smoking has not been investigated in the COPD phenotype associated with biomass [107,108].…”

Section: Pathogenic Mechanismsmentioning

confidence: 99%

Chronic obstructive pulmonary disease in non-smokers: An Update

Alvarado¹

2018

Clin Res Trial

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Tobacco smoking is established as a major risk factor. However, especially in the last 15 years, there are studies have shown that long-term exposure to biomass fuel smoke to cook and heat homes, also carries a high risk for the development of COPD. This occurs particularly in developing countries, and women and children have the highest exposure rates and are therefore more likely to develop the disease. It is estimated that 25-45% of patients with COPD have never smoked and the burden of COPD not associated with smoking is possibly higher than previously believed. Although exposure to biomass is the major risk factor for COPD not associated with smoking, there are other associated factors such as occupational exposure to dust and gases, history of pulmonary tuberculosis, HIV/AIDS, lower respiratory tract infection (particularly in the childhood), chronic asthma, external pollution and poverty. This review exposes the evidence of this association, and some clinical, functional, anatomopathological and therapeutic aspects and particularly the need for preventive interventions to face this other side of the entity that seems to be increasing.

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Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung

Cited by 16 publications

References 48 publications

Evidence of Biomass Smoke Exposure as a Causative Factor for the Development of COPD

Evidence of Biomass Smoke Exposure as a Causative Factor for the Development of COPD

Global nature of airborne particle toxicity and health effects: a focus on megacities, wildfires, dust storms and residential biomass burning

Chronic obstructive pulmonary disease in non-smokers: An Update

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