Comparison of induction characteristics of four intravenous anaesthetic agents

McCollum, J. S. C.; Dundee, John W.

doi:10.1111/j.1365-2044.1986.tb12740.x

Cited by 152 publications

(68 citation statements)

References 13 publications

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“…Diprivan caused a significant decrease in arterial blood pressure with an insignificant increase in heart rate which confirms pre vious studies [4,5,7,8], From this study we conclude that diprivan seems to be an effec tive intravenous anaesthetic agent that can be used successfully to lower ICP in patients with head injuries.…”

Section: Discussionsupporting

confidence: 73%

Effect of Diprivan on Intracranial Pressure in Patients with Head Injuries

Khalid¹,

Kouka²,

Farsakh³

1992

Med Principles Pract

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The effects of diprivan bolus dose on intracranial pressure (ICP) were studied in 10 male patients with head injuries and brain oedema. Diprivan 2.0 mg/kg injected intravenously over 60 s caused statistically significant reduction (p < 0.05) in ICP and cerebral perfusion pressure (CPP) with maximum reduction at 3.0 min. CPP was maintained above 50 mm Hg in all measurements. Arterial blood pressure was decreased significantly (p < 0.05) with the lowest values occurring at 3.0 min for both systolic and mean blood pressure and at 7.0 min for diastolic blood pressure. Heart rate showed no significant change, except at 1-min intervals, where a significant increase was found (p < 0.05). We conclude that diprivan is effective in lowering ICP, while its lowering effect on CCP needs further investigation.

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Section: Discussionsupporting

confidence: 73%

Effect of Diprivan on Intracranial Pressure in Patients with Head Injuries

Khalid¹,

Kouka²,

Farsakh³

1992

Med Principles Pract

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“…Propofol, as a single agent, is the most effective at suppressing the hypertensive response to intubation but it does not do so in a completely reliable fashion. 64,65 No induction agent given alone is adequate for patients with increased ICP who are at risk for a hypertensive response to intubation (Grade C recommendation).…”

Section: Which Is the Best Induction Drug For Rsi?mentioning

confidence: 99%

No evidence for decreased incidence of aspiration after rapid sequence induction

Neilipovitz

Crosby

2007

Can J Anesth/J Can Anesth

150

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Purpose:The purpose of this structured, evidence-based, clinical update was to determine if rapid sequence induction is a safe or effective technique to decrease the risk of aspiration or other complications of airway management. Source:In June 2006 a structured search of MEDLINE from 1966 to present using OVID software was undertaken with the assistance of a reference librarian. Medical subject headings and text words describing rapid sequence induction or intubation (RSI), crash induction or intubation, cricoid pressure and emergency airway intubation were employed. OVID's therapy (sensitivity) algorithm was used to maximize the detection of randomized trials while excluding non-randomized research. The bibliographies of eligible publications were hand-searched to identify trials not identified in the electronic search. Principal findings:A total of 184 clinical trials were identified of which 163 were randomized controlled trials (RCTs). Of these clinical trials, 126 evaluated different drug regimens with 114 being RCTs. Only 21 clinical trials evaluated non-pharmacologic aspects of the RSI with 18 RCTs identified. A parallel search found 52 trials evaluating cricoid pressure (outside of the context of an RSI technique) with 44 classified as RCTs. Definitive outcomes such as prevention of aspiration and mortality benefit could not be evaluated from the trials. Likewise, the impact on adverse outcomes of the different components of RSI could not be ascertained. Conclusion:An absence of evidence from RCTs suggests that the decision to use RSI during management can neither be supported nor discouraged on the basis of quality evidence.

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“…Incidence of pain is reported to be between 28 -90% 8 . However McCollum discovered no measurable change in the occurrence of pain following the change to the current emulsion formulation containing soybean oil 9 .…”

Section: Discussionmentioning

confidence: 99%

Induction Characteristics of Propofol in Children: Comparision with Thiopentone

Panta

Agashe

2013

Med. J. Shree Birendra Hosp.

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Introduction: Induction of anaesthesia has been dominated by intravenous induction agents. The commonest induction agent in use is Sodium Thiopentone. However it is increasingly being replaced by Propofol. The advantage of propofol is faster induction, rapid and clear headed recovery and less postoperative nausea and vomiting. Very little research has been done to compare propofol with thiopentone in children. The aim of this study was to compare the anesthetic effects of thiopentone and propofol in children.

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Comparison of induction characteristics of four intravenous anaesthetic agents

Cited by 152 publications

References 13 publications

Effect of Diprivan on Intracranial Pressure in Patients with Head Injuries

Effect of Diprivan on Intracranial Pressure in Patients with Head Injuries

No evidence for decreased incidence of aspiration after rapid sequence induction

Induction Characteristics of Propofol in Children: Comparision with Thiopentone

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