Comparison of inflammatory markers in non-dipper hypertension vs. dipper hypertension and in normotensive individuals: uric acid, C-reactive protein and red blood cell distribution width readings

Tosu, Aydın Rodi; Demir, Şerafettin; Selçuk, Murat; Kaya, Yüksel; Akyol, Aytaç; Özdemir, Mahmut; Tenekecioğlu, Erhan

doi:10.5114/pwki.2014.43514

Cited by 18 publications

(18 citation statements)

References 29 publications

(27 reference statements)

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“…Our results showed increased inflammation and oxidative stress, are significantly higher in the non-dipper hypertension, which is consistent with the previous study [21]. It was reported that the risk for adverse cardiovascular events in human peaks in the morning, possibly due to the effects of the endogenous circadian system on cardiovascular risk factors, or the occurrence of mental stress.…”

Section: Discussionsupporting

confidence: 93%

CLOCK-induced upregulated HMGB1 resulting in circadian rhythms disruption of inflammatory microglia contributes to non-dipper hypertension in stressed rats

Zhang

Xia

2020

Preprint

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Increased microglia activation and neuroinflammation within autonomic brain regions have been implicated in stress-induced hypertension (SIH). The circadian clock affects physiological cellular and biological processes, including blood pressure (BP) control, but the mechanisms remain unclear. Microglia possess endogenous timekeeping mechanisms regulate immune responses. Here, we explore whether SIH is associated with disrupted diurnal rhythms in microglia proinflammatory factors (PICs) releasing. We found that SIH exhibit diminished BP circadian rhythms, which showed non-dipper hypertension. Microglia isolated from the rostral ventrolateral medulla (RVLM) of SIH rats had aberrant PICs releasing and CLOCK rhythms, while microglia from control rats exhibited robust rhythms of PICs expression both ex vivo and in vivo. In the RVLM, stress upregulated CLOCK expression which is independent of time of day in comparison with that of control. We further identified that upregulated CLOCK depressed sirt1 expression thereby increased oxidative stress-related HMGB1-PICs releasing in microglia in RVLM of SIH rats. In conclusion, the disrupts intrinsic circadian rhythms of microglia-derived PICs releasing involves in pathogeneses of non-dipper hypertension in stressed rats. Highlights• The aberrant rhythms CLOCK gene induced increased HMGB expression in microglia in the RVLM of stress-induced hypertension rats.• Aberrant CLOCK depressed sirt1 expression, which resulted in oxidative stress initiated inflammatory HMGB1 activation in microglia in RVLM of stress-induced hypertension rats.• The disrupts intrinsic circadian rhythms of microglia-derived inflammatory factor releasing in the RVLM involving in pathogeneses of non-dipper hypertension. Graphical abstractAbnormal CLOCK-sirt1-HMGB1 caused the aberrant circadian rhythms of microglial inflammatory factors releasing contributes to non-dipper hypertension. The disrupted circadian of CLOCK resulted in HMGB1 activation via sirt1-dependent oxidative stress in the RVLM.

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Section: Discussionsupporting

confidence: 93%

CLOCK-induced upregulated HMGB1 resulting in circadian rhythms disruption of inflammatory microglia contributes to non-dipper hypertension in stressed rats

Zhang

Xia

2020

Preprint

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“…A nocturnal non-dipping pattern is a situation accompanied by inflammation21) and endothelial dysfunction 17)22). The clinical relevance of a non-dipping status in HT patients lies in its proven association with more severe target organ damage and increased risk for cardiovascular events 23)24).…”

Section: Discussionmentioning

confidence: 99%

Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension

et al. 2016

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Background and ObjectivesNon-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern and plasma endocan levels together with high-sensitivity C-reactive protein (hsCRP) in patients with newly diagnosed untreated hypertension.Subjects and MethodsTwenty-four hour ambulatory blood pressure monitoring was recorded in 35 dipper, 35 non-dipper hypertensives and 35 healthy controls. Endocan levels were measured by enzyme-linked immunosorbent assay. Serum levels of hsCRP were also recorded.ResultsDespite similar daytime and 24-hour average BP values between dippers and non-dippers, statistically significant high nocturnal BP was accompanied by a non-dipping pattern (Systolic BP: 132±9 vs. 147±11 mmHg; Distolic BP: 80±7 vs. 91±9 mmHg, respectively, p<0.001 for both). Non-dipper patients demonstrated higher endocan levels compared to dippers and normotensives (367 (193-844) pg/mL, 254 (182-512) pg/mL and 237 (141-314) pg/ml, respectively, p<0.001). HsCRP levels were significantly higher in non-dippers than the other groups (p=0.013). In a multivariate logistic regression analysis, endocan (p=0.021) and hsCRP (p=0.044) were independently associated with a non-dipping pattern.ConclusionElevated endocan levels were found in non-dipper groups. Endocan and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that elevated levels of endocan in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to the possible future role of endocan in selection of hypertensive patients at higher risk or target organ damage.

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“…3,4 Also, elevated serum uric acid (SUA) concentrations have been observed in HT, cardiovascular diseases, chronic kidney diseases and metabolic syndrome related with inflammatory status. 5,6 In this study, serum NLR, CRP and uric acid levels of patients with CSU were measured and it was investigated whether or not these parameters have an association with clinical disease activity.…”

mentioning

confidence: 99%

Serum C-Reactive Protein, Neutrophil-Lymphocyte Ratio and Uric Acid Levels in Chronic Spontaneous Urticaria

Karabay¹,

Çerman²,

Altunay³

2016

Turkiye Klinikleri J Dermatol

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Recent studies implicate the role of inflammatory responses in chronic spontaneous urticaria (CSU). The purpose of this study was to analyse the levels of neutrophil-lymphocyte ratio (NLR), serum C-reactive protein (CRP) and uric acid levels in CSU patients, and to investigate the relationship between these inflammatory parameters and disease activity. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 100 people, consisting of 50 chronic urticaria patients and 50 healthy controls, who have no systemic disease, inflammatory, infectious or autoimmune disease, malignancy, were included in the study. R Re es su ul lt ts s: : NLR and serum CRP levels were significantly higher in patients with CSU than in healthy controls (p< 0.001, p< 0.001, respectively). The levels of uric acid did not show a statistically significant difference between CSU patients and controls (p= 0.359). A significant positive correlation was found between NLR and CRP in patients with CSU (p= 0.001, r= 0.442).When CSU patients were evaluated according to disease severity, serum CRP levels were significantly higher in patients with severe CSU than in patients with mild-moderate CSU (p= 0.038). C Co on nc cl lu us si io on n: : Several biomarkers have been studied in systemic diseases to determine the inflammatory process ongoing and the relationship between these markers and disease activity has been investigated. It can be concluded that CRP and NLR can be used to assess the inflammatory status in CSU and may be useful parameters during the follow-up of these patients. It is known that NLR and CRP are diagnostic and prognostic markers of cardiovascular diseases. Elevated values of NLR and CRP may demand caution regarding cardiovascular comorbidities that may accompany chronic urticaria.K Ke ey y W Wo or rd ds s: : C-reactive protein; neutrophils; uric acid; urticaria Ö ÖZ ZE ET T A Am ma aç ç: : Son dönemde yapılan çalışmalarda kronik spontan ürtikerde (KSÜ) inflamatuar yanıtın üzerinde durulmaktadır. Bu çalışmanın amacı KSÜ hastalarında nötrofil-lenfosit oranı (NLO), serum C-reaktif proteini (CRP) ve ürik asid düzeylerini belirlemek ve bu inflamatuar parametreler ile hastalık aktivitesi arasında ilişki olup olmadığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Herhangi bir sistemik hastalığı, inflamatuar veya infeksiyöz hastalığı, malignitesi, otoimmün hastalığı olmayan 50 kronik ürtiker hastası ve 50 sağlıklı kontrol olmak üzere toplam 100 kişi çalışmaya dahil edildi. B Bu ul lg gu ul la ar r: : NLO ve CRP düzeyleri KSÜ hastalarında sağlıklı kontrollere göre anlamlı olarak daha yüksekti (p<0,001, p<0,001, sırasıyla). Ürik asid düzeyleri açısından KSÜ hastaları ve sağlıklı kontroller arasında anlamlı bir fark izlenmedi (p=0,359). KSÜ hastalarında NLO ve CRP arasında anlamlı pozitif korelasyon mevcuttu (p=0,001, r=0,442). KSÜ hastaları hastalık şiddetine göre incelendiğinde serum CRP düzeyleri şiddetli KSÜ hastalarında hafif-orta şiddetli KSÜ h...

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Comparison of inflammatory markers in non-dipper hypertension vs. dipper hypertension and in normotensive individuals: uric acid, C-reactive protein and red blood cell distribution width readings

Cited by 18 publications

References 29 publications

CLOCK-induced upregulated HMGB1 resulting in circadian rhythms disruption of inflammatory microglia contributes to non-dipper hypertension in stressed rats

CLOCK-induced upregulated HMGB1 resulting in circadian rhythms disruption of inflammatory microglia contributes to non-dipper hypertension in stressed rats

Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension

Serum C-Reactive Protein, Neutrophil-Lymphocyte Ratio and Uric Acid Levels in Chronic Spontaneous Urticaria

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