Serum C-Reactive Protein, Neutrophil-Lymphocyte Ratio and Uric Acid Levels in Chronic Spontaneous Urticaria

Abstract

A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Recent studies implicate the role of inflammatory responses in chronic spontaneous urticaria (CSU). The purpose of this study was to analyse the levels of neutrophil-lymphocyte ratio (NLR), serum C-reactive protein (CRP) and uric acid levels in CSU patients, and to investigate the relationship between these inflammatory parameters and disease activity. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 100 people, consisting of 50 chronic urticaria patients and 50 healthy controls, who have no systemic disease, inflammatory, infectious or autoimmune disease, malignancy, were included in the study. R Re es su ul lt ts s: : NLR and serum CRP levels were significantly higher in patients with CSU than in healthy controls (p< 0.001, p< 0.001, respectively). The levels of uric acid did not show a statistically significant difference between CSU patients and controls (p= 0.359). A significant positive correlation was found between NLR and CRP in patients with CSU (p= 0.001, r= 0.442).When CSU patients were evaluated according to disease severity, serum CRP levels were significantly higher in patients with severe CSU than in patients with mild-moderate CSU (p= 0.038). C Co on nc cl lu us si io on n: : Several biomarkers have been studied in systemic diseases to determine the inflammatory process ongoing and the relationship between these markers and disease activity has been investigated. It can be concluded that CRP and NLR can be used to assess the inflammatory status in CSU and may be useful parameters during the follow-up of these patients. It is known that NLR and CRP are diagnostic and prognostic markers of cardiovascular diseases. Elevated values of NLR and CRP may demand caution regarding cardiovascular comorbidities that may accompany chronic urticaria.K Ke ey y W Wo or rd ds s: : C-reactive protein; neutrophils; uric acid; urticaria Ö ÖZ ZE ET T A Am ma aç ç: : Son dönemde yapılan çalışmalarda kronik spontan ürtikerde (KSÜ) inflamatuar yanıtın üzerinde durulmaktadır. Bu çalışmanın amacı KSÜ hastalarında nötrofil-lenfosit oranı (NLO), serum C-reaktif proteini (CRP) ve ürik asid düzeylerini belirlemek ve bu inflamatuar parametreler ile hastalık aktivitesi arasında ilişki olup olmadığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Herhangi bir sistemik hastalığı, inflamatuar veya infeksiyöz hastalığı, malignitesi, otoimmün hastalığı olmayan 50 kronik ürtiker hastası ve 50 sağlıklı kontrol olmak üzere toplam 100 kişi çalışmaya dahil edildi. B Bu ul lg gu ul la ar r: : NLO ve CRP düzeyleri KSÜ hastalarında sağlıklı kontrollere göre anlamlı olarak daha yüksekti (p<0,001, p<0,001, sırasıyla). Ürik asid düzeyleri açısından KSÜ hastaları ve sağlıklı kontroller arasında anlamlı bir fark izlenmedi (p=0,359). KSÜ hastalarında NLO ve CRP arasında anlamlı pozitif korelasyon mevcuttu (p=0,001, r=0,442). KSÜ hastaları hastalık şiddetine göre incelendiğinde serum CRP düzeyleri şiddetli KSÜ hastalarında hafif-orta şiddetli KSÜ h...

Correlation of urticaria activity score in chronic spontaneous urticaria with serum C‐reactive protein level and neutrophil/lymphocyte ratio

“…2020;33:e14532. https://doi.org/ 10.1111/dth.14532 T A B L E 5 Comparison of our study with some previous studies Aktaş Karabay et al (2016)13 " in CSU c " in CSU bAleem et al (2014)15 " in CSU cAbbreviations: CSU, chronic spontaneous urticaria; ESR, erythrocyte sedimentation rate; hsCRP, high-sensitivity C-reactive protein; N/L, neutrophil/lymphocyte; UAS, urticaria activity score.…”

“…We found that serum levels of hsCRP and the N/L ratio were significantly higher in CSU patients than in controls. In some previous studies, the mean serum level of hsCRP and the N/L ratio were significantly higher in CSU patients than in controls 13,14 . In Aleem et al's study, 15 an increased CRP level was correlated with an enhanced systemic inflammatory response in CSU patients, although any role for CRP in terms of urticaria pathogenesis remained unclear.…”

“…In some previous studies, the mean serum level of hsCRP and the N/L ratio were significantly higher in CSU patients than in controls. 13,14 In Aleem et al's study, 15 research has found that autoimmune mechanisms play important roles in the etiopathogeneses of 40% to 45% of CSU cases, although the connections remain poorly understood. 9,17 Autoimmune thyroid disease in CSU patients has been extensively researched.…”

Evaluation of carotid intima media thickness and hematologic inflammatory markers in patients with chronic spontaneous urticaria

“…Karabay et al [26] have reported significantly higher NLR values also in CSU patients as compared to healthy controls and also have found a positive correlation between serum CRP values and NLR values in CSU patients. However, they have observed no correlation between clinical disease severity and NLR value [26]. In our study, there was no significant difference in NLR values between the patient group with CSU and the control group, and there was no correlation between CRP and NLR values in the patient group.…”

“…It has been reported in recent years that neutrophils and associated lymphopenia are independent determinants of mortality in cardiovascular diseases and furthermore, NLR has been shown to be an inflammation indication in cardiac and non-cardiac diseases [3,6,[23][24][25]. Karabay et al [26] have reported significantly higher NLR values also in CSU patients as compared to healthy controls and also have found a positive correlation between serum CRP values and NLR values in CSU patients. However, they have observed no correlation between clinical disease severity and NLR value [26].…”