2019
DOI: 10.5812/aapm.96998
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Comparison of Infusion of Propofol and Ketamine-Propofol Mixture (Ketofol) as Anesthetic Maintenance Agents on Blood Pressure of Patients Undergoing Orthopedic Leg Surgeries

Abstract: Background: Some studies have reported the effects of anesthesia induction using a single propofol dose and low ketamine doses in short-term outpatient operations. Objectives: In this study, we aimed to evaluate the intra and post-operative hemodynamic effects of ketamine-propofol mixture (Ketofol) infusion in comparison with propofol infusion. Methods: This study was performed on 54 class I and II of the American Society of Anesthesia patients aged 15 to 45 years who were candidates for leg fracture surgery. … Show more

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Cited by 11 publications
(11 citation statements)
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“…Moreover atropine and ketamine has synergistic in accordance with increased heart rate (Thejasree et al, 2018). Similar trend heart rate noticed in ketofol 1:2 on human orthopaedic patients when compared with cri of propofol (Sabertanha et al, 2019). Oxygen saturation of haemoglobin evidences that significant drop at induction and immediately after induction.…”
Section: Resultssupporting
confidence: 78%
“…Moreover atropine and ketamine has synergistic in accordance with increased heart rate (Thejasree et al, 2018). Similar trend heart rate noticed in ketofol 1:2 on human orthopaedic patients when compared with cri of propofol (Sabertanha et al, 2019). Oxygen saturation of haemoglobin evidences that significant drop at induction and immediately after induction.…”
Section: Resultssupporting
confidence: 78%
“…Rapid induction followed by tracheal intubation is preferred. Ketamine inhibits serotonin uptake at synaptic terminals 9 and increases the risk of nausea and vomiting, which may lead to regurgitation and aspiration 10,11 . Therefore, it should be avoided for anesthesia induction.…”
Section: Discussionmentioning
confidence: 99%
“…Ketamine inhibits serotonin uptake at synaptic terminals 9 and increases the risk of nausea and vomiting, which may lead to regurgitation and aspiration. 10,11 Therefore, it should be avoided for anesthesia induction. The patient should be fasted for 6 h according to age.…”
Section: Discussionmentioning
confidence: 99%
“…Our results are in agreement with those of Aboeldahab et al, as ketofol was associated with more stable hemodynamics than propofol during extubation. Also, Sabertanha A et al, in their study, deduced that the infusion of a combination of ketamine and propofol increased hemodynamic stability and was superior in analgesia compared to the infusion of only propofol ( 20 ). We attributed this to the good sedation level of ketofol during suction and extubation due to the additive analgesic and sedative effect of ketamine and propofol.…”
Section: Discussionmentioning
confidence: 99%