Comparison of intestinal invasion and macrophage response of Salmonella Gallinarum and other host-adapted Salmonella enterica serovars in the avian host

Chadfield, M. S.; Brown, D. J. F.; Aabo, Søren; Christensen, Jens Peter; Olsen, John Elmerdahl

doi:10.1016/s0378-1135(02)00290-0

Cited by 66 publications

(47 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macrophages are integral in the pathogenesis of salmonellosis (Chen et al, 1996;Henderson et al, 1999;Chadfield et al, 2003). In the present study, the presence of agent antigen within the phagosomes of macrophages located in many organs of the adult, although less commonly in the young budgerigars, confirmed intracellular localization of the agent.…”

Section: Discussionsupporting

confidence: 72%

“…In the present study, the presence of agent antigen within the phagosomes of macrophages located in many organs of the adult, although less commonly in the young budgerigars, confirmed intracellular localization of the agent. Similar activity of the agent, as in other species (Henderson et al, 1999;Chadfield et al, 2003), is therefore most likely.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Pathomorphological, immunohistochemical and bacteriological findings in budgerigars (Melopsittacus undulatus) naturally infected withS.Gallinarum

et al. 2012

View full text Add to dashboard Cite

The present study describes the pathological and bacteriological findings and diagnosis by immunoperoxidase and immunofluorescence methods in budgerigars (Melopsittacus undulatus) naturally infected with Salmonella gallinarum obtained from three commercial budgerigar rearing farms. The course of the disease in young budgerigars was peracute or acute, whereas in adult budgerigars the disease was acute or chronic. Clinically, yellowÁwhite diarrhoea was observed in the young budgerigars with the acute form. In the adult budgerigars with the acute and chronic forms, a decrease in feed and water consumption with loss in body condition together with greenish-yellow diarrhoea was generally noted. Peritonitis and pericarditis were the most common findings in young budgerigars at necropsy, while in adult budgerigars scattered greyÁwhite necrotic foci were found in the livers. Histopathologically, the lesions in young budgerigars were characterized with fibrinonecrotic peritonitis and/or pericarditis and necrotic hepatitis. In adult budgerigars with acute infection, hepatic necrosis with focal heterophil infiltration was present; whilst lesions in the chronic cases were granulomatous in nature with the infiltration of macrophages, lymphocytes and histiocytes. For the detection of S. Gallinarum in formalin-fixed, paraffin-embedded tissues, the avidinÁbiotin peroxidase complex and immunofluorescence methods were used. Both methods showed bacteria to be localized in the liver, kidney, peritoneum, heart, spleen and intestines of both young and adult budgerigars. The results of the present study indicate that the avidinÁbiotin peroxidase complex method was more sensitive than the immunofluorescence method in the detection of the bacteria.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 52%

Pathomorphological, immunohistochemical and bacteriological findings in budgerigars (Melopsittacus undulatus) naturally infected withS.Gallinarum

et al. 2012

View full text Add to dashboard Cite

show abstract

“…As mentioned previously, comparative survival in human and murine macrophages correlates with host specificity in S. Typhi and S. Typhimurium (Vladoianu et al 1990;Pascopella et al 1995;Ishibashi and Arai 1996;Schwan 2000;Xu 2009). However, comparative survival in chicken macrophages does not correlate with the avian virulence of S. Gallinarum (Chadfield et al 2003). Cell culture has been useful for understanding the basis of host specificity in hemotropic Bartonella spp.…”

Section: Models To Study Host Specificity Cell Culture Modelsmentioning

confidence: 99%

Host Specificity of Bacterial Pathogens

Bäumler

Fang

2013

Cold Spring Harbor Perspectives in Medicine

173

134

View full text Add to dashboard Cite

“…The systemic virulence of S. enterica serovar Dublin (S. Dublin) in cattle cannot be attributed to survival in primary macrophages, macrophage lysis (Watson et al 2000a), damage to intestinal epithelia (Bolton et al 1999), enteritis (Paulin et al 2002) or to the magnitude of invasion of the ileal mucosa (Bolton et al 1999;Paulin et al 2002). Broadly, the same applies to the systemically virulent serovars Abortusovis in sheep (Uzzau et al 2001), Choleraesuis in pigs (Watson et al 2000b) and Gallinarum in chickens (Chadfield et al 2003), compared with the broad host-range serovar Typhimurium.…”

Section: Salmonellosis In Food-producing Animalsmentioning

confidence: 99%

Molecular insights into farm animal and zoonoticSalmonellainfections

Stevens

Humphrey

Maskell

2009

Phil. Trans. R. Soc. B

145

102

View full text Add to dashboard Cite

Salmonella enterica is a facultative intracellular pathogen of worldwide importance. Infections may present in a variety of ways, from asymptomatic colonization to inflammatory diarrhoea or typhoid fever depending on serovar-and host-specific factors. Human diarrhoeal infections are frequently acquired via the food chain and farm environment by virtue of the ability of selected non-typhoidal serovars to colonize the intestines of food-producing animals and contaminate the avian reproductive tract and egg. Colonization of reservoir hosts often occurs in the absence of clinical symptoms; however, some S. enterica serovars threaten animal health owing to their ability to cause acute enteritis or translocate from the intestines to other organs causing fever, septicaemia and abortion. Despite the availability of complete genome sequences of isolates representing several serovars, the molecular mechanisms underlying Salmonella colonization, pathogenesis and transmission in reservoir hosts remain ill-defined. Here we review current knowledge of the bacterial factors influencing colonization of food-producing animals by Salmonella and the basis of host range, differential virulence and zoonotic potential.

show abstract

Comparison of intestinal invasion and macrophage response of Salmonella Gallinarum and other host-adapted Salmonella enterica serovars in the avian host

Cited by 66 publications

References 39 publications

Pathomorphological, immunohistochemical and bacteriological findings in budgerigars (Melopsittacus undulatus) naturally infected withS.Gallinarum

Pathomorphological, immunohistochemical and bacteriological findings in budgerigars (Melopsittacus undulatus) naturally infected withS.Gallinarum

Host Specificity of Bacterial Pathogens

Molecular insights into farm animal and zoonoticSalmonellainfections

Contact Info

Product

Resources

About