Comparison of Intravenous Nutrients on Gut Mucosal Protein Synthesis

Stein, T. P.; Yoshida, Shogo; Schluter, M. D.; Drews, D.; Assimon, Sue Anne; Leskiw, M. J.

doi:10.1177/0148607194018005447

Cited by 24 publications

(7 citation statements)

References 22 publications

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“…21 In the intestinal lumen, probiotics ferment prebiotics, which leads to the production of butyric acid and other SCFAs. Moreover, IV administration of SCFAs ameliorated mucosal atrophy, 22 and butyric acid-supplemented PN (Bu-PN) both increased intestinal mucosal protein synthesis 23 and stimulated the growth of jejunal and ileal cells in a massive intestinal resection model. 24 However, the effects of Bu-PN on the mass and function of GALT, a center of intestinal and systemic mucosal immunity, remain unclear.…”

Section: Original Communicationmentioning

confidence: 99%

Effects of Adding Butyric Acid to PN on Gut‐Associated Lymphoid Tissue and Mucosal Immunoglobulin A Levels

Murakoshi

Fukatsu

Omata

et al. 2011

J Parenter Enteral Nutr

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Section: Original Communicationmentioning

confidence: 99%

Effects of Adding Butyric Acid to PN on Gut‐Associated Lymphoid Tissue and Mucosal Immunoglobulin A Levels

Murakoshi

Fukatsu

Omata

et al. 2011

J Parenter Enteral Nutr

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“…(b) Ketone bodies, produced in higher amounts during MCT/LCT versus LCT infusion, are known to be a good substrate for the intestinal mucosa [19]. Hence, TPN with MCT/LCT may better protect the integrity of the gut barrier, which would result in less periportal inflammation by reducing the egress of toxins and bacteria from the intestine.…”

Section: Hepatic Functionmentioning

confidence: 99%

Lipid Emulsions in Parenteral Nutrition

Adolph

1999

Ann Nutr Metab

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Lipid emulsions containing a physical mixture of medium and long chain triglycerides (MCT/LCT) are a well-proven concept in parenteral nutrition of critically ill patients. Having a demonstrably higher utilization rate, MCT/LCT emulsions do not impair liver function, produce less immune and no reticuloendothelial system function compromise, and do not interfere with pulmonary hemodynamics or gas exchange. A reduced content of n–6 polyunsaturated fatty acids can also be obtained by using newer preparations based on structured triglycerides or olive oil. Further studies are necessary in order to investigate these new lipid emulsions versus the physical mixture of MCT/LCT. A promising substrate in the development of lipid emulsions can be seen in fish oils. With regard to current literature, fish oils have a beneficial influence on the pathophysiological response to endotoxins and exert important modulations on eicosanoid and cytokine biology. Furthermore their intravenous use may improve organ perfusion in different critical situations.

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“…24 -26 STG seems to be a better support for protein synthesis. 27,28 Like MCT, STG did not affect the RES and did not increase the rate of infection. 29 According to animal studies, randomized STG emulsions have a beneficial effect on triglyceride hydrolysis and nitrogen balance.…”

Section: Experimental Data In Animal Studiesmentioning

confidence: 85%

Structured Triglyceride Emulsions in Parenteral Nutrition

2006

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Over the past 3 decades, various concepts for IV fat emulsions (IVFE) have been developed. A randomized, structured-lipid emulsion based on an old technology has recently become available. This structured-lipid emulsion is produced by mixing medium-chain triglycerides and long-chain triglycerides, then allowing hydrolysis to form free fatty acids, followed by random transesterification of the fatty acids into mixed triglyceride molecules. Studies in animals have shown an improvement in nitrogen balance with the use of these lipid emulsions. Only 8 human clinical studies with these products have been performed. The results of these human clinical studies have been less promising than the animal studies; however, an improvement in nitrogen balance and lipid metabolism exceeds results associated with infusion of long-chain triglycerides (LCT) or a physical mixture of long-chain triglycerides and medium-chain triglycerides (LCT-MCT). Structured-lipid emulsion seems to induce less elevation in serum liver function values compared with standard IVFEs. In addition, structured-lipid emulsions have no detrimental effect on the reticuloendothelial system. Further studies are necessary in order to recommend the use of structured-lipid emulsions. The clinical community hopes that chemically defined structured triglycerides will make it possible to determine the distribution of specific fatty acids on a specific position on the glycerol core and therefore obtain specific activity for a specific clinical situation.

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Comparison of Intravenous Nutrients on Gut Mucosal Protein Synthesis

Abstract: Standard TPN leads to a decrease in gut mucosal protein synthesis in rats, and this decrease can be partially attenuated by adding nutrients for the gut to the TPN mixture.

Cited by 24 publications

References 22 publications

Effects of Adding Butyric Acid to PN on Gut‐Associated Lymphoid Tissue and Mucosal Immunoglobulin A Levels

Effects of Adding Butyric Acid to PN on Gut‐Associated Lymphoid Tissue and Mucosal Immunoglobulin A Levels

Lipid Emulsions in Parenteral Nutrition

Structured Triglyceride Emulsions in Parenteral Nutrition

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