Comparison of Irrigation and Intravenous Antibiotic Prophylaxis at Cesarean Section

Pharmacokinetics of Topical and Intravenous Cefazolin in Patients with Clean Surgical Wounds

“…Conover and Moore measured the febrile index and found parenteral administration superior to topical dosing. 4 Sarr et al studied antibiotic administration in high-risk biliary surgical patients and found antibiotic irrigation to be as effective as parenteral dosing. In animal studies, they also determined that topically administered antibiotics were effective at reducing bacterial counts in experimental wounds.…”

“…1,2 This leads surgeons to treat patients with perioperative antibiotics administered either intravenously, topically, or both. [3][4][5][6][7][8] In 1980, Polk et al reported effective concentrations of cefazolin in surgical wounds after intravenous dosing and postulated its use as an effective antibiotic for surgical wound protection. 9 A recent report from the Veterans Administration system emphasizes the importance of timing perioperative administration of prophylactic antibiotics, advocating dosing either at in-room time or during the procedure.…”

A comparison of postoperative morbidity following prophylactic antibiotic administration by combined irrigation and intravenous route or by intravenous route alone during cesarean section

“…This mechanism of action may include systemic absorption, in addition to any local effect. Prior to DUFF'S investigation, CON-OVER and MOORE [3] had claimed that IV antibiotic prophylaxis was more effective than antibiotic irrigation and that the latter was ineffective in reducing the incidence of endometritis after cesarean delivery.…”

“…In the 1980's, the introduction of prophylactic antibiotic therapy was followed by marked reductions in postoperative febrile morbidity. Reported rates fell to between 15% and 37% [3,4]. Increasing awareness of the value of prophylactic antibiotics for women undergoing cesarean section, plus the growing numbers of women who receive this intervention, led to considerable interest in determining safe and cost effective prophylactic regimens to diminish the risk of endometritis.…”

The Effect of Antibiotic Lavage on Postoperative Peritoneal Adhesion Formation in Rats

“…Postoperatif infeksiyonlann önlenmesinde antibiotikli peritoneal lavajların etkinliği halen tartışmalı bir konu olmaya devam etmektedir. Bazı çalışmalar antibiotikli peritoneal lavajların, abdominal cerrahi sonrası gelişebilecek infeksiyöz komplikasyonları azalttığını gösterirken, diğer bazı yazarlar ise intravenöz antibiotik uygulamaları ile karşılaştırıldığında bu yöntemin ek bir yararlılık getirmediğini öne sürmektedirler (1,2,3,4). öte yandan Rappaport ve arkadaşlan 1989 da yayınladıkları çalışmaları ile bu tartışmaya yeni bir boyut getirmişler, antibiotikli peritoneal lavajların postoperatif yapışıklık oluşumunu arttır dıklarını öne sürmüşlerdir (5).…”