Background: To explore the clinical efficacy and long-term prognosis of laparoscopic technique in patients with gallbladder cancer.Methods: Retrospective analysis and summary of the clinical data of 50 patients with gallbladder carcinoma treated by laparoscope from January 2010 to November 2018 in the Third Affiliated Hospital of Soochow University.Results: The intraoperative or postoperative pathology of 43 cases were confirmed as the gallbladder carcinoma. Among them, 11 cases were confirmed as Tis stage, 12 cases as T1b stage, 20 cases as T2 stage and 7 cases as T3 stage. Follow up data of one patient was lost due to personal reason. During the follow-up period, no one at Tis stage died, two cases at T1b stage died, six cases at T2 stage died and six cases at T3 stage died. Conclusion: Laparoscope is a secure and feasible way in the treatment of gallbladder carcinoma at an early stage, but a large number of clinical data is still required to demonstrate its long-term curative effect.