Comparison of Large-Core Vacuum-Assisted Breast Biopsy and Excision Systems

Ultrasound Guided Therapeutic Excisional Vacuum Assisted Biopsy in Breast Fibroadenomas

“…The main advantage of this method is that it can remove lesions 10-20 mm in size without fragmenting them. However, because it uses RF energy, its use is limited in small breasts and lesions located close to the skin or thoracic wall (15). The ABBI system (Advanced Breast Biopsy Instrumentation, United States Surgical, Norwalk, CT, ABD) is no longer commercially available (4).…”

An Ultra-Sensitive Immunoassay for Quantifying Biomarkers in Breast Tumor Tissue

“…The current study further reduces the required amount of breast cancer tissue to below 1 mg. This would allow the determination of PAI-1 levels in individual 14- to 16-guage needle cores obtained without vacuum assist 36 and in frozen thin tissue sections. The increased sensitivity of the ILPCR assay would also allow PAI-1 levels to be measured in very small tumors, below the current limits of radiologic detection, but detectable by histology 53, 54.…”

“…Current ASCO guidelines recommend 100 to 300mg of fresh or frozen breast cancer tissue for determination of uPA and PAI-1 levels by ELISA 31, 35. The need for this quantity of fresh or frozen breast tumor tissue requires a surgical biopsy or vacuum-assisted core biopsy with an 8-gauge needle 36 and precludes the use of 14-gauge needle-core biopsies that are more common in clinical practice 37. It also imposes a lower limit on the size of analyzable tumors that is well above the detection limit of modern radiological methods Thomassen et al 38 used ELISA to compare normalized uPA and PAI-1 levels measured in 10-30mg core biopsy specimens and 90-300 mg tumor tissue taken from the same specimens immediately after surgery.…”

Digital Mammography

“…33.4 and 33.5 , the third being Mammotome ® , Breast Care, Ethicon Endo-Surgery ® . A comprehensive comparative review of all four VAB systems has been undertaken by Wilson et al (2009) and is recommended reading for the practitioner [ 16 ].…”