Comparison of laser excited fluorescence and photoacoustic limits of detection for static and flow cells

Voigtman, Edward; Jurgensen, A.; Winefordner, J. D.

doi:10.1021/ac00235a045

Cited by 85 publications

(40 citation statements)

References 26 publications

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“…The electric current between two electrodes, which is induced under a strong radiation field, was recorded in multiphoton ionization spectrometry. This technique was developed for the trace analysis of gas phase samples but is also applied to condensed phase samples [17,18]. Theoretically, the sensitivities of these spectrometric methods increase with increasing the laser power and are several orders of magnitude better than those of conventional absorption spectrometry.…”

Section: Landmark Papers From the 1970'smentioning

confidence: 99%

Laser spectroscopy on organic molecules

Imasaka

1996

Analytical and Bioanalytical Chemistry

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Various laser spectrometric methods have been developed until now. Especially, laser fluorometry is most sensitive and is frequently combined with a separation technique such as capillary electrophoresis. For non-fluorescent compounds, photothermal spectrometry may be used instead. A diode laser is potentially useful for practical trace analysis, because of its low cost and long-term trouble-free operation. On the other hand, monochromaticity of the laser is essential in high-resolution spectrometry, e.g. in low temperature spectrometry providing a very sharp spectral feature. Closely-related compounds such as isomers can easily be differentiated, and information for assignment is obtained from the spectrum. Multiphoton ionization mass spectrometry is useful for soft ionization, providing additional information concerned with molecular weight and chemical structure. A short laser pulse with a sufficient energy is suitable for rapid heating of the solid surface. A matrix-assisted laser desorption/ion-ization technique is recently employed for introduction of a large biological molecule into a vacuum for mass analysis. In the future, laser spectrometry will be developed by a combination with state-of-the-art laser technology. In the 21st century, new laser spectrometry will be developed, which may be based on revolutionary ideas or unexpected discoveries. Such studies will open new frontiers in analytical laser spectroscopy.

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Section: Landmark Papers From the 1970'smentioning

confidence: 99%

Laser spectroscopy on organic molecules

Imasaka

1996

Analytical and Bioanalytical Chemistry

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“…One is second harmonic generation (SHG) spectroscopy, which is the most popular for studying liquid surfaces [1][2][3][4][5][6][7][8] and is particularly sensitive to the first layer of a liquid surface. The other is laser two-photon ionization (TPI) spectroscopy, which is sensitive enough to detect probe molecules both in bulk solution [9][10][11][12][13][14] and on the surface of a solution [15][16][17][18][19] or metal. 20 These laser spectroscopy techniques have made it possible to determine the surface concentration of a solute molecule and analyze its equilibrium on the surface and its distribution between the surface and bulk.…”

Section: Introductionmentioning

confidence: 99%

Acid−Base Equilibrium Constants and Distribution Coefficients of Aminopyrene between the Surface and Bulk of Liquid Water as Studied by a Laser Two-Photon Ionization Technique

et al. 2004

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The pH-dependent amount of aminopyrene adsorbed at the water surface was measured using a laser twophoton ionization technique. The distribution coefficients of neutral and cationic aminopyrene between the surface and bulk of liquid water were determined to be 9.6 × 10 -6 m and 2.5 × 10 -7 m, respectively. The acid-base equilibrium constant, pK a , of aminopyrene on the water surface was determined to be 2.0, while that of the same molecule in bulk water was 3.6 ( 0.1. These results show that neutral aminopyrene tends to stay on the water surface, resulting in equilibrium shifts toward the neutral form. It is demonstrated that laser two-photon ionization is a powerful method to analyze the equilibria of a small amount of molecules, 0.17pmol/cm 2 , adsorbed at the water surface.

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“…A molecule can be photoionized in an intense laser field by absorbing two or more photons successively or simultaneously. A simple and sensitive method to detect photoionization is conductivity measurements [1][2][3][4][5]. One atom detection in a gas phase [1] and a ppb level detection in a solution […”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Laser Multi-Photon Ionization Spectrometry

Ogawa

1991

Anal. Sci.

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Comparison of laser excited fluorescence and photoacoustic limits of detection for static and flow cells

Cited by 85 publications

References 26 publications

Laser spectroscopy on organic molecules

Laser spectroscopy on organic molecules

Acid−Base Equilibrium Constants and Distribution Coefficients of Aminopyrene between the Surface and Bulk of Liquid Water as Studied by a Laser Two-Photon Ionization Technique

Recent Progress in Laser Multi-Photon Ionization Spectrometry

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