Comparison of levels of inflammatory mediators IL-1β and βG in gingival crevicular fluid from molars, premolars, and incisors during rapid palatal expansion

Tzannetou, Sappho; Efstratiadis, Stella; Nicolay, Olivier; Grbic, John T.; Lamster, Ira B.

doi:10.1016/j.ajodo.2006.03.044

Cited by 42 publications

(46 citation statements)

References 24 publications

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“…Among these studies, further analysis of the titles, abstracts, and fulltexts revealed that 25 were relevant for the present study. A summary of papers that were excluded is presented in Figure 1 (exhibiting the orthodontic mechanics, GCF sampling methods, and cytokine measurements) [1][2][3][4][5][6][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

Section: Resultsmentioning

confidence: 99%

“…Following this same philosophy of strict oral hygiene, Dudic et al [4] and Tzannetou [2,3] concluded that the increased levels of biochemical markers did not seem to be associated with gingival inflammation. In the study of Dudic et al [4], the levels of IL-1β, SP and PGE 2 were detected immediately after placement of separators.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanical stimuli applied on teeth provoke inflammatory responses in periodontal tissues, with release of inflammatory mediators, inducing the biological processes that promote alveolar bone resorption and apposition [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Most studies have been addressing new mediators and upand down-regulation of these protein levels in different treatments. However, limited information is available from studies on the relationship between orthodontic tooth movement and regulatory proteins in GCF [2,3,9].…”

Section: Introductionmentioning

confidence: 99%

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Cytokines in crevicular fluid and orthodontic force: a systematic review

Allgayer

Menezes

Rinaldi

2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: This paper aimed to analyze studies in the literature addressing the role of cytokines in the gingival crevicular fluid (GCF) in the orthodontic treatment. METHODS: Several databases were surveyed using both MESH terms and free terms. Additional studies were obtained by reference tracking. This review was registered in PROSPERO, and the procedures foreseen by its statement were followed. Data were obtained from the included studies addressing the orthodontic mechanics, GCF sampling/handling methods, and cytokine measurements. Clinical studies written in English were browsed. Papers were selected by one reviewer and checked by a second investigator. RESULTS: A total of 115 articles were identified, among which 25 were selected for detailed analysis. Common drawbacks consisted mainly of inadequacies in the study design (e.g. short duration and small number of study subjects). The most consistent result was a peak of cytokine levels at 1 d. Associations were observed between prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) and pain, velocity of tooth movement, and treatment mechanics. Interleukin-1b and PGE2 showed different patterns of up-regulation, with IL-1β being more responsive to mechanical stress and PGE2 more responsive to synergistic regulation of IL-1β and mechanical force. The results support the use of light continuous forces for orthodontic treatment. CONCLUSION: There was a tendency of maintenance of relatively high IL-1β levels for longer periods with the use of light continuous forces, which might decrease the frequency of activation. These outcomes provide evidence at the cellular level for the utilization of light continuous forces.Key words: Systematic review; Orthodontics, corrective; Gingival Crevicular Fluid (GCF); Interleukin; T Cells.Papel das citocinas presentes no fluido crevicular durante o tratamento ortodôntico: uma revisão sistemática REsUMO OBJETIVO: Este artigo teve como objetivo analisar estudos na literatura abordando o papel das citocinas no Líquido do Sulco Gengival no tratamento ortodôntico. MéTODOS: Várias bases de dados foram pesquisadas usando termos MESH e termos livres. Estudos adicionais foram obtidos por rastreamento de referência. Esta revisão foi registrada no PROSPERO, e os procedimentos previstos por sua declaração foram seguidos. Os dados foram obtidos dos estudos incluídos sobre a mecânica ortodôntica, métodos de amostragem / manuseio de Líquido do Sulco Gengival e medições de citoquinas. Estudos clínicos escritos em inglês foram pesquisados. Os trabalhos foram selecionados por um revisor e verificados por um segundo investigador. RESULTADOS: Foram identificados 115 artigos, dentre os quais 25 foram selecionados para análise detalhada. As desvantagens comuns consistiram principalmente em insuficiências no design do estudo (por exemplo, curta duração e pequeno número de sujeitos do estudo). O resultado mais consistente foi um pico de níveis de citocinas a 1 d. Foram observadas associações entre prostaglandina E2 (PGE2) e interleucina-1β (IL-1β) ...

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytokines in crevicular fluid and orthodontic force: a systematic review

Allgayer

Menezes

Rinaldi

2017

Rev. Odonto Ciênc. (Online)

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“…It is also well known that the inflammation process is important for both the bone as well as the cementum remodeling processes. [1][2][3][4][5] If we consider these wellknown phenomena together, we can name the process related to orthodontic tooth movement, as well as the Inflammatory Root Resorption Concurrent with Orthodontics (IRRCWO), 6 as ''Orthodontitis''. Orthodontitis, then, is the inflammation behind tooth movement, where the prefix is our profession and the suffix ''itis'' 7 is used in medical terminology to describe inflammation of an organ or a tissue.…”

mentioning

confidence: 99%