Comparison of levels of serum copper, zinc, albumin, globulin and alkaline phosphatase in psoriatic patients and controls: A hospital based casecontrol study

Abstract

Background:Psoriasis is a chronic, immune-mediated skin disease with unknown etiology, with an epidermal turnover time of <10 days compared to a normal turnover time of 4-8 weeks. This epidermal hyperproliferation accounts for many of the metabolic abnormalities including alteration in the serum levels of proteins and some trace elements.Aim:The aim was to detect any statistically significant difference in the serum levels of zinc, copper, albumin, globulin and alkaline phosphatase between psoriasis patients and healthy controls.Materials and Methods:Hundred cases of psoriasis and 100 age and sex matched controls were enrolled in a hospital based case-control study. The serum levels of zinc, copper, albumin, globulin and alkaline phosphatase were calculated and compared among the cases and controls and evaluated statistically.Results:Serum zinc levels were significantly low in the psoriasis group as compared with controls (mean 80.028 μg/dl vs. 109.179 μg/dl, P < 0.0001). Serum copper levels were significantly raised among cases as compared with controls (mean 167.317 μg/dl vs. 133.884 μg/dl P < 0.0001). Serum albumin levels were significantly decreased (3.762 g/dl vs. 4.103 g/dl, P < 0.001), whereas serum globulin levels were raised (3.296 g/dl vs. 2.596 g/dl, P = 0.0014) among cases as compared with controls, respectively. Serum alkaline phosphatase levels were comparable between the two groups.Conclusion:The results of this study show significant alterations in the serum levels of copper, zinc, albumin, and globulin in psoriatic patients. This paper aims at highlighting the possible role of trace metals copper and zinc in the aetiopathogenesis of psoriasis and also provides a proposed interplay of factors involved in the pathogenesis of psoriasis.

Evaluation of the levels of trace elements in the blood and hair of patients with seborrheic dermatitis

“…There was no statistically significant difference between the ML group and the control group (p < 0.05) [11]. In another study evaluating patients with psoriasis, serum Cu levels were found to be significantly higher in the psoriasis group (p < 0.0001) [13]. In a similar way, serum Cu values obtained in our study were found to be significantly higher in the SD group than in the control group.…”

“…The authors concluded that Zn, which acts as a cofactor for metalloenzymes in many cellular pathways, can be used in the treatment of acne due to its anti-inflammatory activity. In another study by Sheikh et al [13] in patients with psoria- sis, it was found that serum Zn levels were significantly lower in the psoriatic group than in the control group (p < 0.0001). In a study, in which serum Zn was investigated in a patient group with SD, although serum Zn level was higher in the SD group than in the control group, no statistically significant difference was found between the two groups (p = 0.507) [14].…”

Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis

“…1 ). Increased levels of copper [ 95 , 96 ] and free reactive iron [ 34 ] were found in psoriatic patients. When comparison of copper data was done between groups of psoriasis severity, a significant difference was found between mild, moderate and severe groups [ 96 ].…”

Study of Serum Alkaline Phosphatase Levels among Psoriasis Patients and Comparative Group in Tertiary Care Institute

“…Found 14,21 significantly raised serum alkaline phosphatase levels in psoriasis cases 17,22 whereas found no significant alteration in serum alkaline phosphatase levels in psoriasis patients. The finding in our study is in concordance with these latter studies.…”

“…Oxidative stress is a known risk factor for exacerbation of psoriasis. Metalloenzymes such as alkaline phosphatase and Superoxide dismutase reduce the oxidative stress 17 . Serum alkaline phosphatase level is a marker of oxidative stress in body.…”